{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:35:53Z","timestamp":1787801753218,"version":"build-2784847793"},"reference-count":105,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jilin College of Agricultural Science and Technology Projects","award":["20230049"],"award-info":[{"award-number":["20230049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Liver disease is a global health problem that affects the well-being of tens of thousands of people. Dihydroquercetin (DHQ) is a flavonoid compound derived from various plants. Furthermore, DHQ has shown excellent activity in the prevention and treatment of liver injury, such as the inhibition of hepatocellular carcinoma cell proliferation after administration, the normalization of oxidative indices (like SOD, GSH) in this tissue, and the down-regulation of pro-inflammatory molecules (such as IL-6 and TNF-\u03b1). DHQ also exerts its therapeutic effects by affecting molecular pathways such as NF-\u03baB and Nrf2. This paper discusses the latest research progress of DHQ in the treatment of various liver diseases (including viral liver injury, drug liver injury, alcoholic liver injury, non-alcoholic liver injury, fatty liver injury, and immune liver injury). It explores how to optimize the application of DHQ to improve its effectiveness in treating liver diseases, which is valuable for preparing potential therapeutic drugs for human liver diseases in conjunction with DHQ.<\/jats:p>","DOI":"10.3390\/molecules29153537","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T09:50:05Z","timestamp":1722246605000},"page":"3537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mechanism of Action of Dihydroquercetin in the Prevention and Therapy of Experimental Liver Injury"],"prefix":"10.3390","volume":"29","author":[{"given":"Hewei","family":"Wei","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Food and Pharmaceutical Engineering, Wuzhou University, Wuzhou 543002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food and Pharmaceutical Engineering, Wuzhou University, Wuzhou 543002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiteng","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China"},{"name":"School of Food and Pharmaceutical Engineering, Wuzhou University, Wuzhou 543002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junran","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Bi","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-0540","authenticated-orcid":false,"given":"Zhiqiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbo","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China"},{"name":"College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food and Pharmaceutical Engineering, Wuzhou University, Wuzhou 543002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ding, L., Liu, Y., Kang, M., Wei, X., Geng, C., Liu, W., Han, L., Yuan, F., Wang, P., and Wang, B. 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