{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:53:18Z","timestamp":1784955198581,"version":"3.55.0"},"reference-count":21,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT and Ministry of Education","doi-asserted-by":"publisher","award":["2018R1A6A1A03025582"],"award-info":[{"award-number":["2018R1A6A1A03025582"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT and Ministry of Education","doi-asserted-by":"publisher","award":["RS-2024-00352515"],"award-info":[{"award-number":["RS-2024-00352515"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT and Ministry of Education","doi-asserted-by":"publisher","award":["2022R1A6C101A739"],"award-info":[{"award-number":["2022R1A6C101A739"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003716","name":"the Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education","doi-asserted-by":"publisher","award":["2018R1A6A1A03025582"],"award-info":[{"award-number":["2018R1A6A1A03025582"]}],"id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003716","name":"the Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education","doi-asserted-by":"publisher","award":["RS-2024-00352515"],"award-info":[{"award-number":["RS-2024-00352515"]}],"id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003716","name":"the Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education","doi-asserted-by":"publisher","award":["2022R1A6C101A739"],"award-info":[{"award-number":["2022R1A6C101A739"]}],"id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nanofiber (NF) membrane systems that can provide cascade catalytic reaction and ferroptosis induction were developed for oral cancer therapy. Glucose oxidase (GOx) and aminoferrocene (AF) were introduced into the NF system for glucose deprivation\/H2O2 generation and OH radical generation, respectively. GOx offers starvation therapy and AF (including iron) provides chemodynamic therapy\/ferroptosis for combating oral cancer. GOx (water-soluble) and AF (poorly water-soluble) molecules were successfully entrapped in the NF membrane via an electrospinning process. GOx and AF were incorporated into the polyvinyl alcohol (PVA)-based NF, resulting in PVA\/GOx\/AF NF with fast disintegration and immediate drug-release properties. In oral squamous cell carcinoma (YD-9 cells), the PVA\/GOx\/AF NF group exhibited higher cytotoxicity, antiproliferation potential, cellular ROS level, apoptosis induction, lipid ROS level, and malondialdehyde level compared to the other NF groups. The electrospun PVA\/GOx\/AF NF can be directly applied to oral cancer without causing pain, offering starvation\/chemodynamic therapy and ferroptosis induction.<\/jats:p>","DOI":"10.3390\/molecules29163964","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T06:28:51Z","timestamp":1724308131000},"page":"3964","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cascade Hydroxyl Radical-Generating and Ferroptosis-Inducing Nanofiber System for the Therapy of Oral Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"29","author":[{"given":"JiHye","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaojun","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da In","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3039-8035","authenticated-orcid":false,"given":"Sungyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"},{"name":"Kangwon Institute of Inclusive Technology, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongnam","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usok","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-9371","authenticated-orcid":false,"given":"Hyun-Jong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Wu, Y., Du, H., Li, Z., Bai, X., Wu, Y., Li, H., Zhou, M., Cao, Y., and Chen, X. 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