{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:42:24Z","timestamp":1791686544343,"version":"4.3.4"},"reference-count":55,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["21571109"],"award-info":[{"award-number":["21571109"]}]},{"name":"National Natural Science Foundation of China","award":["2023PY002"],"award-info":[{"award-number":["2023PY002"]}]},{"name":"National Natural Science Foundation of China","award":["2023PY003"],"award-info":[{"award-number":["2023PY003"]}]},{"name":"National Natural Science Foundation of China","award":["SYKF2023018"],"award-info":[{"award-number":["SYKF2023018"]}]},{"name":"Nanyang Normal University","award":["21571109"],"award-info":[{"award-number":["21571109"]}]},{"name":"Nanyang Normal University","award":["2023PY002"],"award-info":[{"award-number":["2023PY002"]}]},{"name":"Nanyang Normal University","award":["2023PY003"],"award-info":[{"award-number":["2023PY003"]}]},{"name":"Nanyang Normal University","award":["SYKF2023018"],"award-info":[{"award-number":["SYKF2023018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To synthesize an effective and versatile nano-platform serving as a promising carrier for controlled drug delivery, visible-light-induced diselenide-crosslinked polyurethane micelles were designed and prepared for ROS-triggered on-demand doxorubicin (DOX) release. A rationally designed amphiphilic block copolymer, poly(ethylene glycol)-b-poly(diselenolane diol-co-isophorone diisocyanate)-b-poly(ethylene glycol) (PEG-b-PUSe-b-PEG), which incorporates dangling diselenolane groups within the hydrophobic PU segments, was initially synthesized through the polycondensation reaction. In aqueous media, this type of amphiphilic block copolymer can self-assemble into micellar aggregates and encapsulate DOX within the micellar core, forming DOX-loaded micelles that are subsequently in situ core-crosslinked by diselenides via a visible-light-triggered metathesis reaction of Se-Se bonds. Compared with the non-crosslinked micelles (NCLMs), the as-prepared diselenide-crosslinked micelles (CLMs) exhibited a smaller particle size and improved colloidal stability. In vitro release studies have demonstrated suppressed drug release behavior for CLMs in physiological conditions, as compared to the NCLMs, whereas a burst release of DOX occurred upon exposure to an oxidation environment. Moreover, MTT assay results have revealed that the crosslinked polyurethane micelles displayed no significant cytotoxicity towards HeLa cells. Cellular uptake analyses have suggested the effective internalization of DOX-loaded crosslinked micelles and DOX release within cancer cells. These findings suggest that this kind of ROS-triggered reversibly crosslinked polyurethane micelles hold significant potential as a ROS-responsive drug delivery system.<\/jats:p>","DOI":"10.3390\/molecules29163970","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T11:14:41Z","timestamp":1724325281000},"page":"3970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Visible-Light-Induced Diselenide-Crosslinked Polymeric Micelles for ROS-Triggered Drug Delivery"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0586-9687","authenticated-orcid":false,"given":"Xinfeng","family":"Cheng","sequence":"first","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixian","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxu","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianchao","family":"Du","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Xing","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.addr.2013.09.008","article-title":"Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers","volume":"66","author":"Li","year":"2014","journal-title":"Adv. Drug Deliver. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1021\/acsmacrolett.2c00137","article-title":"Core-Cross-Linking of Polymeric Micelles by Di-para-Substituted S-Aroylthiooximes as Linkers for Controlled H2S Release","volume":"11","author":"Rong","year":"2022","journal-title":"ACS Macro Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1039\/D0PY00987C","article-title":"Reduction-responsive disulfide linkage core-cross-linked polymeric micelles for site-specific drug delivery","volume":"11","author":"Kuang","year":"2020","journal-title":"Polym. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.2174\/0929867324666171121102255","article-title":"Recent Progress of Crosslinking Strategies for Polymeric Micelles with Enhanced Drug Delivery in Cancer Therapy","volume":"26","author":"Fan","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1800541","DOI":"10.1002\/marc.201800541","article-title":"Recent Developments in the Area of Click-Crosslinked Nanocarriers for Drug Delivery","volume":"40","author":"Dai","year":"2019","journal-title":"Macromol. Rapid Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1007\/s12274-018-2152-3","article-title":"Strategies to improve micelle stability for drug delivery","volume":"11","author":"Lu","year":"2018","journal-title":"Nano Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/pol.20230270","article-title":"Rational design of hyper-crosslinked polymers for biomedical applications","volume":"62","author":"Liao","year":"2024","journal-title":"J. Polym. Sci."},{"key":"ref_8","unstructured":"Grumezescu, A.M. (2019). Chapter 5\u2014Reversible core-shell crosslinked micelles for controlled release of bioactive agents. Nanoarchitectonics in Biomedicine, William Andrew Publishing."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.1021\/acs.biomac.3c00832","article-title":"Reversible Cross-linked Thermoresponsive Polycaprolactone Micelles for Enhanced Stability and Controlled Release","volume":"24","author":"Bhadran","year":"2023","journal-title":"Biomacromolecules"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"124024","DOI":"10.1016\/j.polymer.2021.124024","article-title":"Recent advances in development of imine-based acid-degradable polymeric nanoassemblies for intracellular drug delivery","volume":"230","author":"Hu","year":"2021","journal-title":"Polymer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1039\/C5PY01783A","article-title":"Preparation of pH and redox dual-sensitive core crosslinked micelles for overcoming drug resistance of DOX","volume":"7","author":"Yi","year":"2016","journal-title":"Polym. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2000365","DOI":"10.1002\/macp.202000365","article-title":"Synthesis of Photo, Oxidation, Reduction Triple-Stimuli-Responsive Interface-Cross-Linked Polymer Micelles as Nanocarriers for Controlled Release","volume":"222","author":"Guo","year":"2021","journal-title":"Macromol. Chem. Phys."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1002\/pol.20220053","article-title":"pH responsive, reversible photo-crosslinkable micelle in layer-by-layer assembly-Study on film growth and drug delivery behavior","volume":"60","author":"Song","year":"2022","journal-title":"J. Polym. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1039\/C5RA22476D","article-title":"Amphiphilic functional block copolymers bearing a reactive furfuryl group via RAFT polymerization; reversible core cross-linked micelles via a Diels-Alder \u201cclick reaction\u201d","volume":"6","author":"Pramanik","year":"2016","journal-title":"RSC Adv."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1039\/C6SC04650A","article-title":"Near-IR-induced dissociation of thermally-sensitive star polymers","volume":"8","author":"Dai","year":"2017","journal-title":"Chem. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1039\/D3PY00641G","article-title":"Synthesis of redox-responsive core-shell nanoparticles: Insights into core-crosslinking efficiency","volume":"14","author":"Olszowy","year":"2023","journal-title":"Polym. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13216","DOI":"10.1021\/am404213w","article-title":"Graft Copolymer Nanoparticles with pH and Reduction Dual-Induced Disassemblable Property for Enhanced Intracellular Curcumin Release","volume":"5","author":"Zhao","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12757","DOI":"10.1039\/D1RA00079A","article-title":"A reduction-responsive drug delivery with improved stability: Disulfide crosslinked micelles of small amiphiphilic molecules","volume":"11","author":"Li","year":"2021","journal-title":"RSC Adv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"132321","DOI":"10.1016\/j.colsurfa.2023.132321","article-title":"Reduction-sensitive shell crosslinked TPGS micelles: Formulation and colloidal characterizations","volume":"677","author":"Sarolia","year":"2023","journal-title":"Colloids Surf. A-Physicochem. Eng. Asp."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1021\/acs.macromol.0c01031","article-title":"Dithiolane-Crosslinked Poly(\u03b5-caprolactone)-Based Micelles: Impact of Monomer Sequence, Nature of Monomer, and Reducing Agent on the Dynamic Crosslinking Properties","volume":"53","author":"Liu","year":"2020","journal-title":"Macromolecules"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.actbio.2023.08.043","article-title":"Integrin-targeting disulfide-crosslinked micellar docetaxel eradicates lung and prostate cancer patient-derived xenografts","volume":"170","author":"Ni","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1039\/D1TB01253C","article-title":"Recent developments in selenium-containing polymeric micelles: Prospective stimuli, drug-release behaviors, and intrinsic anticancer activity","volume":"9","author":"Birhan","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1039\/D0TB02190C","article-title":"Recent progress of redox-responsive polymeric nanomaterials for controlled release","volume":"9","author":"Hsu","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.xphs.2022.12.015","article-title":"Mesoscopic Simulations of Diselenide-Containing Crosslinked Doxorubicin-Loaded Micelles and Their Tumor Microenvironment Responsive Release Behaviors","volume":"112","author":"Lin","year":"2023","journal-title":"J. Pharm. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2202135","DOI":"10.1002\/adhm.202202135","article-title":"Diselenide-Based Dual-Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy","volume":"12","author":"Wan","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yang, J., Pan, S., Gao, S., Li, T., and Xu, H. (2021). CO\/chemosensitization\/antiangiogenesis synergistic therapy with H2O2-responsive diselenide-containing polymer. Biomaterials, 271.","DOI":"10.1016\/j.biomaterials.2021.120721"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1021\/acsmaterialslett.0c00272","article-title":"From Selenite to Diselenide-Containing Drug Delivery Systems","volume":"2","author":"Sun","year":"2020","journal-title":"ACS Mater. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.nantod.2015.11.004","article-title":"Selenium\/tellurium containing polymer materials in nanobiotechnology","volume":"10","author":"Cao","year":"2015","journal-title":"Nano Today"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/ar4000339","article-title":"Selenium-Containing Polymers: Promising Biomaterials for Controlled Release and Enzyme Mimics","volume":"46","author":"Xu","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biomaterials.2016.06.044","article-title":"In situ diselenide-crosslinked polymeric micelles for ROS-mediated anticancer drug delivery","volume":"103","author":"Deepagan","year":"2016","journal-title":"Biomaterials"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1039\/C8PY00961A","article-title":"Near-infrared light-responsive, diselenide containing core-cross-linked micelles prepared by the Diels-Alder click reaction for photocontrollable drug release application","volume":"9","author":"Salma","year":"2018","journal-title":"Polym. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biomaterials.2017.01.002","article-title":"Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy","volume":"121","author":"Zhai","year":"2017","journal-title":"Biomaterials"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Birhan, Y.S., Darge, H.F., Hanurry, E.Y., Andrgie, A.T., Mekonnen, T.W., Chou, H.-Y., Lai, J.-Y., and Tsai, H.-C. (2020). Fabrication of Core Crosslinked Polymeric Micelles as Nanocarriers for Doxorubicin Delivery: Self-Assembly, In Situ Diselenide Metathesis and Redox-Responsive Drug Release. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12060580"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15252","DOI":"10.1039\/D0RA01776K","article-title":"A redox-sensitive core-crosslinked nanosystem combined with ultrasound for enhanced deep penetration of nanodiamonds into tumors","volume":"10","author":"Li","year":"2020","journal-title":"RSC Adv."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Siboro, S.A.P., Salma, S.A., Kim, H.-R., Jeong, Y.T., Gal, Y.-S., and Lim, K.T. (2020). Diselenide Core Cross-Linked Micelles of Poly(Ethylene Oxide)-b-Poly(Glycidyl Methacrylate) Prepared through Alkyne-Azide Click Chemistry as a Near-Infrared Controlled Drug Delivery System. Materials, 13.","DOI":"10.3390\/ma13122846"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"112417","DOI":"10.1016\/j.eurpolymj.2023.112417","article-title":"Intracellular delivery of anticancer agents using dual responsive nanomicelles synthesized via RAFT polymerization","volume":"198","author":"Esmaeili","year":"2023","journal-title":"Eur. Polym. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"119699","DOI":"10.1016\/j.carbpol.2022.119699","article-title":"Diselenide-crosslinked carboxymethyl chitosan nanoparticles for doxorubicin delivery: Preparation and in vivo evaluation","volume":"292","author":"Wang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.1002\/anie.201403442","article-title":"Dynamic Diselenide Bonds: Exchange Reaction Induced by Visible Light without Catalysis","volume":"53","author":"Ji","year":"2014","journal-title":"Angew. Chem.-Int. Ed."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1601293","DOI":"10.1002\/adhm.201601293","article-title":"Redox-Activatable ATP-Depleting Micelles with Dual Modulation Characteristics for Multidrug-Resistant Cancer Therapy","volume":"6","author":"Wang","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1021\/acsapm.9b00413","article-title":"Development of L-Lysine Based Biodegradable Polyurethanes and Their Dual-Responsive Amphiphilic Nanocarriers for Drug Delivery to Cancer Cells","volume":"1","author":"Joshi","year":"2019","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1021\/bm401342t","article-title":"Construction of Targeting-Clickable and Tumor-Cleavable Polyurethane Nanomicelles for Multifunctional Intracellular Drug Delivery","volume":"14","author":"Song","year":"2013","journal-title":"Biomacromolecules"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.1002\/adma.201503661","article-title":"Visible-Light-Induced Self-Healing Diselenide-Containing Polyurethane Elastomer","volume":"27","author":"Ji","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10777","DOI":"10.1039\/C9TC03536B","article-title":"Swelling-induced 3D photopatterning on a diselenide-containing elastomer","volume":"7","author":"Fan","year":"2019","journal-title":"J. Mater. Chem. C"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/anie.201810588","article-title":"Surface Modification Based on Diselenide Dynamic Chemistry: Towards Liquid Motion and Surface Bioconjugation","volume":"58","author":"Xia","year":"2019","journal-title":"Angew. Chem.-Int. Ed."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"13272","DOI":"10.1021\/acs.langmuir.2c02407","article-title":"Dynamic Fluorescent Patterning Based on Visible-Light-Responsive Diselenide Metathesis","volume":"38","author":"Si","year":"2022","journal-title":"Langmuir"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/adhm.201300308","article-title":"Disulfide Cross-Linked Polyurethane Micelles as a Reduction-Triggered Drug Delivery System for Cancer Therapy","volume":"3","author":"Yu","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1039\/C2SM27028E","article-title":"Novel shell-cross-linked micelles with detachable PEG corona for glutathione-mediated intracellular drug delivery","volume":"9","author":"Wang","year":"2013","journal-title":"Soft Matter"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3891\/acta.chem.scand.12-0582","article-title":"A new synthesis of 6-selenoctic Acid and a Relatived Compound","volume":"12","author":"Bergson","year":"1958","journal-title":"Acta Chem. Scand."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.actbio.2017.01.007","article-title":"Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(\u03b5-caprolactone) micelles","volume":"50","author":"Fang","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1039\/C6PY01423B","article-title":"Redox-responsive, core-crosslinked degradable micelles for controlled drug release","volume":"7","author":"Xia","year":"2016","journal-title":"Polym. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0168-3659(87)90034-4","article-title":"A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs","volume":"5","author":"Ritger","year":"1987","journal-title":"J. Control. Release"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0168-3659(87)90035-6","article-title":"A simple equation for description of solute release II. Fickian and anomalous release from swellable devices","volume":"5","author":"Ritger","year":"1987","journal-title":"J. Control. Release"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.apsb.2018.11.006","article-title":"Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy","volume":"9","author":"Zhong","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1706963","DOI":"10.1002\/adma.201706963","article-title":"Highly Augmented Drug Loading and Stability of Micellar Nanocomplexes Composed of Doxorubicin and Poly(ethylene glycol)-Green Tea Catechin Conjugate for Cancer Therapy","volume":"30","author":"Liang","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1002\/anie.200250653","article-title":"Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change","volume":"42","author":"Bae","year":"2003","journal-title":"Angew. Chem.-Int. Ed."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/16\/3970\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:41:31Z","timestamp":1760110891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/16\/3970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":55,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["molecules29163970"],"URL":"https:\/\/doi.org\/10.3390\/molecules29163970","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]}}}