{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:55:01Z","timestamp":1789167301130,"version":"build-2803163510"},"reference-count":206,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Plants are a rich source of secondary metabolites, among which phenolics are the most abundant. To date, over 8000 various polyphenolic compounds have been identified in plant species, among which phenolic acids, flavonoids, coumarins, stilbenes and lignans are the most important ones. Acne is one of the most commonly treated dermatological diseases, among which acne vulgaris and rosacea are the most frequently diagnosed. In the scientific literature, there is a lack of a detailed scientific presentation and discussion on the importance of plant phenolics in the treatment of the most common specific skin diseases, e.g., acne. Therefore, the aim of this review is to gather, present and discuss the current state of knowledge on the activity of various plant phenolics towards the prevention and treatment of acne, including in vitro, in vivo and human studies. It was revealed that because of their significant antibacterial, anti-inflammatory and antioxidant activities, phenolic compounds may be used in the treatment of various types of acne, individually as well as in combination with commonly used drugs like clindamycin and benzoyl peroxide. Among the various phenolics that have been tested, EGCG, quercetin and nobiletin seem to be the most promising ones; however, more studies, especially clinical trials, are needed to fully evaluate their efficacy in treating acne.<\/jats:p>","DOI":"10.3390\/molecules29174234","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T06:18:35Z","timestamp":1725603515000},"page":"4234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Plant Phenolics in the Prevention and Therapy of Acne: A Comprehensive Review"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-9657","authenticated-orcid":false,"given":"Wojciech","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Medical University of Lublin, 4a Chod\u017aki Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-2882","authenticated-orcid":false,"given":"Justyna","family":"Zag\u00f3rska","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Medical University of Lublin, 4a Chod\u017aki Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2244-4118","authenticated-orcid":false,"given":"Magdalena","family":"Michalak-Tomczyk","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Toxicology, The John Paul II Catholic University of Lublin, Konstantyn\u00f3w 1I Street, 20-708 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sercan","family":"Karav","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale 17000, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-4577","authenticated-orcid":false,"given":"Anna","family":"Wawruszak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"McGrowder, D.A., Miller, F.G., Nwokocha, C.R., Anderson, M.S., Wilson-Clarke, C., Vaz, K., Anderson-Jackson, L., and Brown, J. 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