{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:24:48Z","timestamp":1790162688864,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development and Promotion Projects in Henan Province","award":["222102520032"],"award-info":[{"award-number":["222102520032"]}]},{"name":"Key Research and Development and Promotion Projects in Henan Province","award":["242102310422"],"award-info":[{"award-number":["242102310422"]}]},{"name":"Key Research and Development and Promotion Projects in Henan Province","award":["23B150008"],"award-info":[{"award-number":["23B150008"]}]},{"name":"Key Scientific Research Projects of Colleges and Universities in Henan Province","award":["222102520032"],"award-info":[{"award-number":["222102520032"]}]},{"name":"Key Scientific Research Projects of Colleges and Universities in Henan Province","award":["242102310422"],"award-info":[{"award-number":["242102310422"]}]},{"name":"Key Scientific Research Projects of Colleges and Universities in Henan Province","award":["23B150008"],"award-info":[{"award-number":["23B150008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A novel approach for the \u03b1-alkylation of ketones was developed using Br\u00f8nsted acid-catalyzed C-C bond cleavage. Both aromatic and aliphatic ketones reacted smoothly with 2-substituted 1,3-diphenylpropane-1,3-diones to afford \u03b1-alkylation products with high yields and with excellent regioselectivity, in which the 1,3-dicarbonyl group acted as a leaving group in the presence of the catalyst TfOH. Mechanism experiments showed that the \u03b2-C-C bond cleavage of diketone and the shift of the equilibrium towards the enol formation from ketone are driving forces that induce the desired products.<\/jats:p>","DOI":"10.3390\/molecules29174266","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T04:15:01Z","timestamp":1725855301000},"page":"4266","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Br\u00f8nsted Acid Catalyzed C-C Bond Activation and \u03b1-Alkylation of Ketones"],"prefix":"10.3390","volume":"29","author":[{"given":"Wenjuan","family":"Li","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabo","family":"Han","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Engineering Research Center of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan Engineering Research Center of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxu","family":"Chu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopei","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Engineering Research Center of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1021\/ar700133y","article-title":"Metal-Organic Cooperative Catalysis in C-H and C-C Bond Activation and Its Concurrent Recovery","volume":"41","author":"Park","year":"2008","journal-title":"Acc. 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