{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:20:07Z","timestamp":1787062807985,"version":"build-2736575974"},"reference-count":16,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Science and Technology (MEST), Republic of Korea","award":["KSN2411011"],"award-info":[{"award-number":["KSN2411011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, a new secobutanolide, named secosubamolide B (3), along with three previously known secobutanolides (1, 2, and 4), were successfully isolated from a methanol extract of the stem of Lindera obtusiloba. The chemical structures of these compounds were elucidated through the analysis of spectroscopic data, and then compared with the existing literature to confirm their identities. Furthermore, the anti-inflammatory effect of these isolated compounds on bone marrow-derived dendritic cells stimulated by lipopolysaccharide (LPS) was evaluated. Compounds 1\u20133 showed the significant suppression of LPS-triggered IL-6 and IL-12 p40 production, with IC50 values between 1.8 and 24.1 \u00b5M. These findings may provide a scientific foundation for developing anti-inflammatory agents from L. obtusiloba.<\/jats:p>","DOI":"10.3390\/molecules29184292","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T11:01:42Z","timestamp":1725966102000},"page":"4292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Secobutanolides Isolated from Lindera obtusiloba Stem and Their Anti-Inflammatory Activity"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-0201","authenticated-orcid":false,"given":"Hye Jin","family":"Yang","sequence":"first","affiliation":[{"name":"College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea"},{"name":"Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-3655","authenticated-orcid":false,"given":"Young-Sang","family":"Koh","sequence":"additional","affiliation":[{"name":"School of Medicine and Brain Korea 21 PLUS Program, Institute of Medical Science, Jeju National University, Jeju 690-756, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4865-6506","authenticated-orcid":false,"given":"MinKyun","family":"Na","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-7290","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"ref_1","first-page":"65","article-title":"Essential oils from leaves and twigs of Lindera obtusiloba","volume":"96","author":"Kwon","year":"2007","journal-title":"J. Korean For. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3839\/jabc.2011.030","article-title":"Isolation of Flavonoids and Lignans from the Stem Wood of Lindera Obtusioba Blume","volume":"54","author":"Seo","year":"2011","journal-title":"J. Appl. Biol. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF02979069","article-title":"Two new lignans from Lindera obtusiloba blume","volume":"22","author":"Kwon","year":"1999","journal-title":"Arch. Pharm. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00210-011-0643-9","article-title":"An ethanolic extract of Lindera obtusiloba stems causes NO-mediated endothelium-dependent relaxations in rat aortic rings and prevents angiotensin II-induced hypertension and endothelial dysfunction in rats","volume":"383","author":"Lee","year":"2011","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1055\/s-0029-1186053","article-title":"New secoisolariciresinol derivatives from Lindera obtusiloba stems and their neuroprotective activities","volume":"76","author":"Lee","year":"2010","journal-title":"Planta Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"PI27","DOI":"10.1055\/s-0029-1234791","article-title":"Antioxidant and whitening effects of Lindera obtusiloba BL. 70% EtOH extract","volume":"75","author":"Bang","year":"2009","journal-title":"Planta Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1248\/cpb.48.614","article-title":"New cytotoxic butanolides from Lindera obtusiloba BLUME","volume":"48","author":"Kwon","year":"2000","journal-title":"Chem. Pharm. Bull."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1055\/s-2002-20260","article-title":"Cytotoxic butanolides and secobutanolides from the stem wood of Formosan Lindera communis","volume":"68","author":"Tsai","year":"2002","journal-title":"Planta Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lin, C.T., Chu, F.H., Chang, S.T., Chueh, P.J., Su, Y.C., Wu, K.T., and Wang, S.Y. (2007). Secoaggregatalactone-A from Lindera aggregata induces apoptosis in human hepatoma hep G2 cells. Planta Med., 1548\u22121553.","DOI":"10.1055\/s-2007-993739"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1128\/iai.65.2.395-404.1997","article-title":"Salmonella typhi stimulation of human intestinal epithelial cells induces secretion of epithelial cell-derived interleukin-6","volume":"65","author":"Weinstein","year":"1997","journal-title":"Infect. Immun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1056\/NEJMoa033402","article-title":"Anti-interleukin-12 antibody for active Crohn\u2019s disease","volume":"351","author":"Mannon","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.it.2006.11.002","article-title":"IL-12p40: An inherently agonistic cytokine","volume":"28","author":"Cooper","year":"2007","journal-title":"Trends Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s12272-011-0419-2","article-title":"Inhibitory effect of ginsenosides from steamed ginseng-leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells","volume":"34","author":"Tung","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.phytochem.2005.03.020","article-title":"Steryl epoxide, secobutanolide and butanolides from the stem wood of Machilus zuihoensis","volume":"66","author":"Cheng","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"da Costa-Silva, T.A., Conserva, G.A.A., Galisteo, A.J., Tempone, A.G., and Lago, J.H.G. (2019). Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae). J. Venom. Anim. Toxins. Incl. Trop. Dis., e20190008.","DOI":"10.1590\/1678-9199-jvatitd-2019-0008"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/14786410903098277","article-title":"A new butanolide and a new secobutanolide from Litsea lii var. nunkao-tahangensis","volume":"24","author":"Cheng","year":"2010","journal-title":"Nat. Prod. Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/18\/4292\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:53:20Z","timestamp":1760111600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/18\/4292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":16,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["molecules29184292"],"URL":"https:\/\/doi.org\/10.3390\/molecules29184292","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,10]]}}}