{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:24:18Z","timestamp":1760145858850,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Base for International Science and Technology Cooperation of Chengdu University","award":["ISTC202301","22301032"],"award-info":[{"award-number":["ISTC202301","22301032"]}]},{"name":"National Natural Science Foundation of China","award":["ISTC202301","22301032"],"award-info":[{"award-number":["ISTC202301","22301032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method for synthesizing ketones. However, the scope of these substrates remains relatively limited, particularly due to their incompatibility with sensitive functional groups. Herein, we report a Ni-catalyzed three-component 1,2-carboacylation of alkenes, which activates secondary\/tertiary alkyl bromides. This method offers significant advantages: simplicity of operation, ready availability of substrates, and broad substrate applicability. A series of experimental studies have helped clarify the key mechanistic pathways involved in this cascade reaction.<\/jats:p>","DOI":"10.3390\/molecules29184295","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T02:34:49Z","timestamp":1726022089000},"page":"4295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes"],"prefix":"10.3390","volume":"29","author":[{"given":"Shengzhou","family":"Jin","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanfen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Sciences, Northeastern University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinggang","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Sciences, Northeastern University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Ma","sequence":"additional","affiliation":[{"name":"Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, National Base for International Science and Technology Cooperation of Chengdu University, Chengdu University, Chengdu 610106, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Sciences, Northeastern University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1212\/WNL.48.1.81","article-title":"Tolcapone Improves Motor Function and Reduces Levodopa Requirement in Patients with Parkinson\u2019s Disease Experiencing Motor Fluctuations: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial","volume":"48","author":"Kurth","year":"1997","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1039\/b100919m","article-title":"Structure-based design of agrochemicals","volume":"19","author":"Walter","year":"2002","journal-title":"Nat. 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