{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:35:22Z","timestamp":1776400522111,"version":"3.51.2"},"reference-count":41,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"publisher","award":["UBACYT 20020220300118BA"],"award-info":[{"award-number":["UBACYT 20020220300118BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"publisher","award":["PICT 2020 SERIEA-03061"],"award-info":[{"award-number":["PICT 2020 SERIEA-03061"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"publisher","award":["PICT 2019 N\u00ba3367"],"award-info":[{"award-number":["PICT 2019 N\u00ba3367"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National Agency for Science and Technology Promotion","award":["UBACYT 20020220300118BA"],"award-info":[{"award-number":["UBACYT 20020220300118BA"]}]},{"name":"The National Agency for Science and Technology Promotion","award":["PICT 2020 SERIEA-03061"],"award-info":[{"award-number":["PICT 2020 SERIEA-03061"]}]},{"name":"The National Agency for Science and Technology Promotion","award":["PICT 2019 N\u00ba3367"],"award-info":[{"award-number":["PICT 2019 N\u00ba3367"]}]},{"name":"CONICET","award":["UBACYT 20020220300118BA"],"award-info":[{"award-number":["UBACYT 20020220300118BA"]}]},{"name":"CONICET","award":["PICT 2020 SERIEA-03061"],"award-info":[{"award-number":["PICT 2020 SERIEA-03061"]}]},{"name":"CONICET","award":["PICT 2019 N\u00ba3367"],"award-info":[{"award-number":["PICT 2019 N\u00ba3367"]}]},{"name":"\u201cResearch Network Natural Products against Neglected Diseases\u201d (ResNet NPND)","award":["UBACYT 20020220300118BA"],"award-info":[{"award-number":["UBACYT 20020220300118BA"]}]},{"name":"\u201cResearch Network Natural Products against Neglected Diseases\u201d (ResNet NPND)","award":["PICT 2020 SERIEA-03061"],"award-info":[{"award-number":["PICT 2020 SERIEA-03061"]}]},{"name":"\u201cResearch Network Natural Products against Neglected Diseases\u201d (ResNet NPND)","award":["PICT 2019 N\u00ba3367"],"award-info":[{"award-number":["PICT 2019 N\u00ba3367"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cestodes are etiological agents of neglected diseases such as echinococcosis and cysticercosis, which are major public health problems. Antiparasitic treatment relies on a small number of approved drugs, which are often only partially effective, poorly tolerated and require prolonged administration. Thus, the discovery of novel potential treatments is critical. The Stevia genus (Asteraceae) includes species that are recognized as a source of bioactive compounds, with many species associated with medicinal uses. In this study, the cestocidal activity of four South American Stevia species that previously showed antiprotozoal activity was analyzed using a motility assay on the laboratory cestode model, Mesocestoides vogae. The four Stevia extracts showed cestocidal activity, with S. alpina var. alpina as the most active. The sesquiterpene lactones estafietin and eupatoriopicrin were purified from S. alpina var. alpina and S. maimarensis, respectively, and tested on M. vogae. Estafietin showed cestocidal activity, inhibiting parasite viability in a dose-dependent manner, even from the first day of incubation. Consistent with the motility effects, the extract of S. alpina var. alpina and estafietin induced marked alterations in the morphology of the parasite. The results of this report show that Stevia species represent a source of new molecules with potential for the treatment of neglected tropical diseases caused by cestodes.<\/jats:p>","DOI":"10.3390\/molecules29184430","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:49:19Z","timestamp":1726652959000},"page":"4430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extracts and Terpenoids from Stevia Species as Potential Anthelmintics for Neglected Tropical Diseases Caused by Cestode Parasites"],"prefix":"10.3390","volume":"29","author":[{"given":"Mar\u00eda del Pilar","family":"Cevasco Contreras","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina"},{"name":"Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPaM) (UBA-CONICET), 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M\u00e9dica (IMPaM) (UBA-CONICET), Universidad de Buenos Aires, Paraguay 2155, Piso 13, Buenos Aires C1113AAD, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando Germ\u00e1n","family":"Elso","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Farmacognosia, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"},{"name":"Unidad de Microan\u00e1lisis y M\u00e9todos F\u00edsicos Aplicados a Qu\u00edmica Org\u00e1nica (UMYMFOR) (UBA-CONICET), Ciudad Universitaria, Pabell\u00f3n 2, Piso 3, Buenos Aires C1428EGA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hern\u00e1n","family":"Bach","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Tecnolog\u00eda Agropecuaria, Nicolas Repetto y De los Reseros s\/n, Hurlingham, Buenos Aires B1686IQN, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-5303","authenticated-orcid":false,"given":"Cesar Atilio Nazareno","family":"Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica, Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Ayacucho 471, San Miguel de Tucum\u00e1n T4000INI, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-0226","authenticated-orcid":false,"given":"Augusto Ernesto","family":"Bivona","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU) (UBA-CONICET), Jun\u00edn 956, Piso 4, Buenos Aires C1113AAD, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo Rolando","family":"Vaca","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Facultad de Medicina, 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