{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:16:03Z","timestamp":1792440963445,"version":"4.5.0"},"reference-count":100,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["22367011"],"award-info":[{"award-number":["22367011"]}]},{"name":"National Natural Science Foundation of China","award":["22367012"],"award-info":[{"award-number":["22367012"]}]},{"name":"National Natural Science Foundation of China","award":["20224BAB216006"],"award-info":[{"award-number":["20224BAB216006"]}]},{"name":"National Natural Science Foundation of China","award":["2021BSQD24"],"award-info":[{"award-number":["2021BSQD24"]}]},{"name":"National Natural Science Foundation of China","award":["2023QNBJRC005"],"award-info":[{"award-number":["2023QNBJRC005"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["22367011"],"award-info":[{"award-number":["22367011"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["22367012"],"award-info":[{"award-number":["22367012"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["20224BAB216006"],"award-info":[{"award-number":["20224BAB216006"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["2021BSQD24"],"award-info":[{"award-number":["2021BSQD24"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["2023QNBJRC005"],"award-info":[{"award-number":["2023QNBJRC005"]}]},{"name":"Doctoral Initiation Fund","award":["22367011"],"award-info":[{"award-number":["22367011"]}]},{"name":"Doctoral Initiation Fund","award":["22367012"],"award-info":[{"award-number":["22367012"]}]},{"name":"Doctoral Initiation Fund","award":["20224BAB216006"],"award-info":[{"award-number":["20224BAB216006"]}]},{"name":"Doctoral Initiation Fund","award":["2021BSQD24"],"award-info":[{"award-number":["2021BSQD24"]}]},{"name":"Doctoral Initiation Fund","award":["2023QNBJRC005"],"award-info":[{"award-number":["2023QNBJRC005"]}]},{"name":"Youth Top Talent Fund Project of Jiangxi Science and Technology Normal University","award":["22367011"],"award-info":[{"award-number":["22367011"]}]},{"name":"Youth Top Talent Fund Project of Jiangxi Science and Technology Normal University","award":["22367012"],"award-info":[{"award-number":["22367012"]}]},{"name":"Youth Top Talent Fund Project of Jiangxi Science and Technology Normal University","award":["20224BAB216006"],"award-info":[{"award-number":["20224BAB216006"]}]},{"name":"Youth Top Talent Fund Project of Jiangxi Science and Technology Normal University","award":["2021BSQD24"],"award-info":[{"award-number":["2021BSQD24"]}]},{"name":"Youth Top Talent Fund Project of Jiangxi Science and Technology Normal University","award":["2023QNBJRC005"],"award-info":[{"award-number":["2023QNBJRC005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Naphthylimides play a pivotal role as aromatic heterocyclic compounds, serving as the foundational structures for numerous pharmacologically significant drugs. These drugs encompass antibacterial, antifungal, anticancer, antimalarial, antiviral, anti-inflammatory, antithrombotic, and antiprotozoal agents. The planar and heteroaromatic characteristics of naphthylimides grant them a strong ability to intercalate into DNA. This intercalation property renders naphthylimide derivatives highly valuable for various biological activities. The advantageous pharmacological activity and ease of synthesis associated with naphthylimides and their derivatives provide significant benefits in the design and development of new compounds within this class. Currently, only a few such molecules are undergoing preclinical and clinical evaluations. In this paper, we have compiled the literature on naphthylimides reported by researchers from 2006 to 2024. Our focus lies on exploring the pharmacological activities of their analogues from a drug development and discovery perspective, while examining their structure\u2013activity relationship and mechanisms of action.<\/jats:p>","DOI":"10.3390\/molecules29194529","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T08:54:13Z","timestamp":1727168053000},"page":"4529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery"],"prefix":"10.3390","volume":"29","author":[{"given":"Wei","family":"Ruan","sequence":"first","affiliation":[{"name":"School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouling","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Qiao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1080\/07391102.2023.2187640","article-title":"A review on medicinally important heterocyclic compounds and importance of biophysical approach of underlying the insight mechanism in biological environment","volume":"41","author":"Karthikeyan","year":"2023","journal-title":"J. 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