{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:36:29Z","timestamp":1783373789112,"version":"3.54.6"},"reference-count":33,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Fund of Wuyi University-Macau","award":["2019WGALH01"],"award-info":[{"award-number":["2019WGALH01"]}]},{"name":"Joint Fund of Wuyi University-Macau","award":["111"],"award-info":[{"award-number":["111"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["2019WGALH01"],"award-info":[{"award-number":["2019WGALH01"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["111"],"award-info":[{"award-number":["111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Antibiotics are currently used for the treatment of Helicobacter pylori (H. pylori), which is confirmed to be the major cause of gastric disorders. However, the long-term consumption of antibiotics has already caused antibiotic resistance and side effects in vivo. Therefore, there is an emerging need for searching for safe and effective anti-H. pylori agents. Inspired by the excellent bioactivities of cinnamic acid, a series of cinnamic acid derivatives (compounds 1\u201330) were synthesized and determined for H. pylori inhibition. The initial screening revealed that compound 23, a 2,4-dinitro cinnamic acid derivative containing 4-methoxyphenol, showed excellent H. pylori inhibition with an MIC value of 4 \u03bcM. Further studies indicated that compound 23 showed anti-bacterial activity and had a bactericidal effect on H. pylori due to the destruction of the bacterial structure. Molecular docking analysis revealed that the 2,4-dinitro groups in cinnamic acid moiety formed hydrogen bonding with amino acid residues in an active pocket of H. pylori protein. Interestingly, the ester moiety fitted into the hydrophobic pocket, attaining additional stability to compound 23. Above all, the present study reveals that compound 23 could be considered a promising anti-H. pylori agent to treat H. pylori causing gastritis.<\/jats:p>","DOI":"10.3390\/molecules29194548","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T16:16:37Z","timestamp":1727280997000},"page":"4548","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of Cinnamic Acid Derivatives as Potent Anti-H. pylori Agents"],"prefix":"10.3390","volume":"29","author":[{"given":"Yonglian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"},{"name":"School of Eco-Environment Technology, Guangdong Industry Polytechnic University, Guangzhou 510300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2951-8108","authenticated-orcid":false,"given":"Vincent Kam Wai","family":"Wong","sequence":"additional","affiliation":[{"name":"Neher\u2019s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-843X","authenticated-orcid":false,"given":"Wenfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/CMR.10.4.720","article-title":"Helicobacter pylori","volume":"10","author":"Dunn","year":"1997","journal-title":"Clin. 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