{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:57:33Z","timestamp":1771300653355,"version":"3.50.1"},"reference-count":105,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Development Plan Project of Jilin Province","award":["YDZJ202201ZYTS186"],"award-info":[{"award-number":["YDZJ202201ZYTS186"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Anemone baicalensis Turcz., a botanical species with a rich historical background in traditional medicine for detoxification and insecticidal applications, possesses a vast, yet largely unexplored, therapeutic potential. This study primarily focused on conducting a qualitative phytochemical analysis of the plant, determining the active ingredient content and antioxidant activity of various solvent extracts. The qualitative phytochemical analysis revealed the presence of 12 different types of phytochemicals within the plant. Utilizing ultraviolet-visible spectrophotometry, we identified 11 active ingredients in 4 solvent extracts. Notably, the methanol extract was found to contain high concentrations of total carbohydrate, total monoterpenoid, total phenolic, total tannin, and total triterpenoid. In the antioxidant experiment, the methanol extract demonstrated superior scavenging abilities against 1,1-diphenyl-2-picrylhydrazyl radical, 2,2\u2032-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid) diammonium salt, superoxide anion radical, and hydrogen peroxide, outperforming other extracts in chelation experiments aimed at reducing iron and metal ions. Consequently, the methanol extract was selected for further investigation. Subsequent ultrahigh-performance liquid chromatography-electrospray ionization-quadrupole-time of flight-mass spectrometry analysis revealed that the methanol extract contained 39 compounds, primarily phenolic compounds and triterpenoid saponins. Three stability assessments confirmed the extract\u2019s stability under high temperatures, varying pH levels, and simulated gastrointestinal processes. Additionally, oil stability testing demonstrated its antioxidant capacity in extra virgin olive oil and cold-pressed sunflower seed oil media. An oral acute toxicity experiment conducted on mice not only confirmed the absence of acute toxicity in the methanol extract but also provided a dose reference for subsequent gastric protection experiments. Notably, the methanol extract exhibited significant gastroprotective effects against ethanol-induced gastric lesions in rats, as evidenced by histopathological and biochemical analyses. Specifically, the extract reduced levels of malondialdehyde, alanine aminotransferase, and aspartate aminotransferase while increasing glutathione, nitric oxide, and catalase, indicating its gastroprotective mechanism. These findings suggest that the methanol extract from the aerial part of Anemone baicalensis could be a promising therapeutic agent for conditions associated with oxidative imbalances. They underscore the plant\u2019s potential therapeutic benefits and offer valuable insights into its antioxidant properties, thereby broadening our understanding of its medicinal potential.<\/jats:p>","DOI":"10.3390\/molecules29194602","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T11:19:33Z","timestamp":1727435973000},"page":"4602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phytochemical Analysis and Antioxidant Activities of Various Extracts from the Aerial Part of Anemone baicalensis Turcz.: In Vitro and In Vivo Studies"],"prefix":"10.3390","volume":"29","author":[{"given":"Shuang","family":"Sun","sequence":"first","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangqing","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133000, China"},{"name":"School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"},{"name":"Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"},{"name":"School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Benxi 117004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"},{"name":"Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"},{"name":"Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-2888","authenticated-orcid":false,"given":"Hao","family":"Zang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133000, China"},{"name":"School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China"},{"name":"Key Laboratory of Evaluation and Application of Changbai Mountain Biological Gerplasm Resources of Jilin Province, Tonghua 134002, China"},{"name":"School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Benxi 117004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"ref_1","unstructured":"Flora of China Editorial Committee of Chinese Academy of Sciences (1980). 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