{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:16:48Z","timestamp":1781720208358,"version":"3.54.5"},"reference-count":36,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170405"],"award-info":[{"award-number":["32170405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022SCP003"],"award-info":[{"award-number":["2022SCP003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022YKZY001"],"award-info":[{"award-number":["2022YKZY001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the High-level Talent Promotion and Training Project of Kunming","award":["32170405"],"award-info":[{"award-number":["32170405"]}]},{"name":"the High-level Talent Promotion and Training Project of Kunming","award":["2022SCP003"],"award-info":[{"award-number":["2022SCP003"]}]},{"name":"the High-level Talent Promotion and Training Project of Kunming","award":["2022YKZY001"],"award-info":[{"award-number":["2022YKZY001"]}]},{"name":"the Project of Yunnan Characteristic Plant Screening and R&amp;D Service CXO Platform","award":["32170405"],"award-info":[{"award-number":["32170405"]}]},{"name":"the Project of Yunnan Characteristic Plant Screening and R&amp;D Service CXO Platform","award":["2022SCP003"],"award-info":[{"award-number":["2022SCP003"]}]},{"name":"the Project of Yunnan Characteristic Plant Screening and R&amp;D Service CXO Platform","award":["2022YKZY001"],"award-info":[{"award-number":["2022YKZY001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Three novel ent-kaurane diterpenes, namely sigesbeckin A\u2013C (1\u20133), in conjunction with eight previously identified analogues (4\u201311), were isolated from Sigesbeckia orientalis. Their chemical structures were resolved through multiple spectroscopic analyses. All compounds were assessed for antimicrobial bioactivity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) strains. In particular, compounds 1 and 5 demonstrated moderate efficacy, with MIC values of 64 \u03bcg\/mL. Moreover, compounds 3, 5, and 11 were found to synergize with doxorubicin hydrochloride (DOX) and vancomycin (VAN) against MRSA and VRE. The aforementioned findings offer valuable insights for the development of novel alternatives to antibiotics, which can effectively tackle the escalating issue of antibiotic resistance.<\/jats:p>","DOI":"10.3390\/molecules29194631","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:39:35Z","timestamp":1727678375000},"page":"4631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Three New Ent-Kaurane Diterpenes with Antibacterial Activity from Sigesbeckia orientalis"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-7679","authenticated-orcid":false,"given":"Zhong-Shun","family":"Zhou","sequence":"first","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0279-9058","authenticated-orcid":false,"given":"Zhao-Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4661-2287","authenticated-orcid":false,"given":"Bei","family":"Tian","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6178-203X","authenticated-orcid":false,"given":"Yan-Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Zhen","family":"Wei","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6768-5679","authenticated-orcid":false,"given":"Xiao-Dong","family":"Luo","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"},{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1183\/09031936.00007709","article-title":"What is MRSA?","volume":"34","author":"Pantosti","year":"2009","journal-title":"Eur. 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