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Thus, in this study, a practical, efficient, and green method was developed for the synthesis of aromatic ketones by applying a bis(2-butoxyethyl) ether\/O2 system under external catalyst-, additive-, and base-free conditions. This O2-mediated oxidation system can tolerate various functional groups and is suitable for large-scale synthesis. Diverse target ketones were prepared under clean conditions in moderate-to-high yields. The late-stage functionalization of drug derivatives with the corresponding ketones and one-pot sequential chemical conversions to ketone downstream products further broaden the application prospects of this approach.<\/jats:p>","DOI":"10.3390\/molecules29204909","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T03:49:34Z","timestamp":1729136974000},"page":"4909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bis(2-butoxyethyl) Ether-Promoted O2-Mediated Oxidation of Alkyl Aromatics to Ketones under Clean Conditions"],"prefix":"10.3390","volume":"29","author":[{"given":"Yangyang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Material and Chemical Engineering, Hunan Institute of Technology, Hengyang 421002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Material and Chemical Engineering, Hunan Institute of Technology, Hengyang 421002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Material and Chemical Engineering, Hunan Institute of Technology, Hengyang 421002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Material and Chemical Engineering, Hunan Institute of Technology, Hengyang 421002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Material and Chemical Engineering, Hunan Institute of Technology, Hengyang 421002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Material and Chemical Engineering, Hunan Institute of Technology, Hengyang 421002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaijian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Material and Chemical Engineering, Hunan Institute of Technology, Hengyang 421002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center, Hunan Automotive Engineering Vocational College, Zhuzhou 412001, China"},{"name":"College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejun","family":"Luo","sequence":"additional","affiliation":[{"name":"Changsha Research Institute of Mining and Metallurgy Co., Ltd., Changsha 410012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12795","DOI":"10.1021\/acs.iecr.3c01588","article-title":"Selective catalytic oxidation of ethylbenzene to acetophenone: A review of catalyst systems and reaction mechanisms","volume":"62","author":"Azeez","year":"2023","journal-title":"Ind. 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