{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:52:13Z","timestamp":1791607933647,"version":"4.3.4"},"reference-count":55,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key R&amp;D Program of Shandong Province","award":["2022LZGCQY013"],"award-info":[{"award-number":["2022LZGCQY013"]}]},{"name":"Key R&amp;D Program of Shandong Province","award":["2024BS27"],"award-info":[{"award-number":["2024BS27"]}]},{"name":"Key R&amp;D Program of Shandong Province","award":["ZDYF2024GXJS005"],"award-info":[{"award-number":["ZDYF2024GXJS005"]}]},{"name":"Key R&amp;D Program of Shandong Province","award":["ZDKJ202016"],"award-info":[{"award-number":["ZDKJ202016"]}]},{"name":"Weifang University Doctor Initiation Fund Project","award":["2022LZGCQY013"],"award-info":[{"award-number":["2022LZGCQY013"]}]},{"name":"Weifang University Doctor Initiation Fund Project","award":["2024BS27"],"award-info":[{"award-number":["2024BS27"]}]},{"name":"Weifang University Doctor Initiation Fund Project","award":["ZDYF2024GXJS005"],"award-info":[{"award-number":["ZDYF2024GXJS005"]}]},{"name":"Weifang University Doctor Initiation Fund Project","award":["ZDKJ202016"],"award-info":[{"award-number":["ZDKJ202016"]}]},{"name":"Key Research and Development Project of Hainan Province, China","award":["2022LZGCQY013"],"award-info":[{"award-number":["2022LZGCQY013"]}]},{"name":"Key Research and Development Project of Hainan Province, China","award":["2024BS27"],"award-info":[{"award-number":["2024BS27"]}]},{"name":"Key Research and Development Project of Hainan Province, China","award":["ZDYF2024GXJS005"],"award-info":[{"award-number":["ZDYF2024GXJS005"]}]},{"name":"Key Research and Development Project of Hainan Province, China","award":["ZDKJ202016"],"award-info":[{"award-number":["ZDKJ202016"]}]},{"name":"Major Science and Technology Plan of Hainan Province, China","award":["2022LZGCQY013"],"award-info":[{"award-number":["2022LZGCQY013"]}]},{"name":"Major Science and Technology Plan of Hainan Province, China","award":["2024BS27"],"award-info":[{"award-number":["2024BS27"]}]},{"name":"Major Science and Technology Plan of Hainan Province, China","award":["ZDYF2024GXJS005"],"award-info":[{"award-number":["ZDYF2024GXJS005"]}]},{"name":"Major Science and Technology Plan of Hainan Province, China","award":["ZDKJ202016"],"award-info":[{"award-number":["ZDKJ202016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A series of hybrid hydrogels of poly(ethylene glycol) (PEG) were synthesized using gelatin as a crosslinker and investigated for controlled delivery of the first-generation cephalosporin antibiotic, Cefazedone sodium (CFD). A commercially available 4-arm-PEG\u2013OH was first modified to obtain four-arm-PEG\u2013succinimidyl glutarate (4-arm-PEG\u2013SG), which formed the gelatin\u2013PEG composite hydrogels (SnNm) through crosslinking with gelatin. To regulate the drug delivery, SnNm hydrogels with various solid contents and crosslinking degrees were prepared. The effect of solid contents and crosslinking degrees on the thermal, mechanical, swelling, degradation, and drug release properties of the hydrogels were intensively investigated. The results revealed that increasing the crosslinking degree and solid content of SnNm could not only enhance the thermal stability, swelling ratio (SR), and compression resistance capacity of SnNm but also prolong the degradation and drug release times. The release kinetics of the SnNm hydrogels were found to follow the first-order model, suggesting that the transport rate of CFD within the matrix of hydrogels is proportional to the concentration of the drug where it is located. Specifically, S1N1-III showed 90% mass loss after 60 h of degradation and a sustained release duration of 72 h. The cytotoxicity assay using the MTT method revealed that cell viability rates of S1N1 were higher than 95%, indicating excellent cytocompatibility. This study offers new insights and methodologies for the development of hydrogels as biomedical composite materials.<\/jats:p>","DOI":"10.3390\/molecules29204952","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T09:58:24Z","timestamp":1729504704000},"page":"4952","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Crosslinked Biodegradable Hybrid Hydrogels Based on Poly(ethylene glycol) and Gelatin for Drug Controlled Release"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6046-4655","authenticated-orcid":false,"given":"Zhenzhen","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Advanced Agricultural Science, Weifang University, Weifang 261061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Advanced Agricultural Science, Weifang University, Weifang 261061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-5648","authenticated-orcid":false,"given":"Zhaosheng","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Su","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5543-6296","authenticated-orcid":false,"given":"Yanan","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1007\/s10853-024-10103-x","article-title":"A Review of Recent Advances in Drug Loading, Mathematical Modeling and Applications of Hydrogel Drug Delivery Systems","volume":"59","author":"Hu","year":"2024","journal-title":"J. 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