{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:45:00Z","timestamp":1790012700692,"version":"4.0.1"},"reference-count":36,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Type 2 diabetes (T2D), characterized by insulin resistance and \u03b2-cell dysfunction, requires continuous advancements in management strategies, particularly in controlling postprandial hyperglycemia to prevent complications. Current antidiabetics, which have \u03b1-amylase and \u03b1-glucosidase inhibitory activities, have side effects, prompting the search for better alternatives. In addition, diabetes patients are particularly vulnerable to yeast infections because an unusual sugar concentration promotes the growth of Candida spp. in areas like the mouth and genitalia. Asphodelus microcarpus contains bioactive flavonoids with potential enzyme inhibitory properties. This study investigates \u03b1-amylase and \u03b1-glucosidase inhibitory activities and antioxidant and antimycotic capacity of ethanolic extracts from different parts of A. microcarpus. Results show that extracts significantly inhibit \u03b1-glucosidase, with the IC50 value being up to 25 times higher than for acarbose, while exerting low \u03b1-amylase activity. The extracts also demonstrated strong antioxidant properties and low cytotoxicity. The presence of phenolic compounds is likely responsible for the observed biological activities. Molecular docking analysis of 11 selected compounds identified emodin and luteolin as significant inhibitors of \u03b1-glucosidase. Additionally, the extracts demonstrated significant antibiofilm action against an MDR strain of Candida albicans. These findings suggest that A. microcarpus is a promising source of natural compounds for T2D management.<\/jats:p>","DOI":"10.3390\/molecules29215063","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:47:18Z","timestamp":1730101638000},"page":"5063","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biological Potential of Asphodelus microcarpus Extracts: \u03b1-Glucosidase and Antibiofilm Activities In Vitro"],"prefix":"10.3390","volume":"29","author":[{"given":"Sonia","family":"Floris","sequence":"first","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari, SS 554-Bivio per Sestu, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-7966","authenticated-orcid":false,"given":"Francesca","family":"Pintus","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari, SS 554-Bivio per Sestu, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3009-4226","authenticated-orcid":false,"given":"Antonella","family":"Fais","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari, SS 554-Bivio per Sestu, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4154-9740","authenticated-orcid":false,"given":"Benedetta","family":"Era","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari, SS 554-Bivio per Sestu, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Raho","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Medical Science and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1574-7347","authenticated-orcid":false,"given":"Chiara","family":"Siguri","sequence":"additional","affiliation":[{"name":"Institute for Genetic and Biomedical Research (IRGB), The National Research Council (CNR), 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-4431","authenticated-orcid":false,"given":"Germano","family":"Orr\u00f9","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fais","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-3333","authenticated-orcid":false,"given":"Carlo Ignazio Giovanni","family":"Tuberoso","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari, SS 554-Bivio per Sestu, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-671X","authenticated-orcid":false,"given":"Stefania","family":"Olla","sequence":"additional","affiliation":[{"name":"Institute for Genetic and Biomedical Research (IRGB), The National Research Council (CNR), 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Di Petrillo","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Medical Science and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"ref_1","first-page":"e45615","article-title":"The Bidirectional Link Between Diabetes and Kidney Disease: Mechanisms and Management","volume":"15","author":"Kumar","year":"2023","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cerf, M.E. 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