{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:03:06Z","timestamp":1765382586493,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Committee of Science of the Ministry of Science and High Education of the Republic of Kazakhstan","award":["AP19676539","BR21882220","AP19675500"],"award-info":[{"award-number":["AP19676539","BR21882220","AP19675500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The synthesized compound, 1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP), and its 1:1 complex with \u03b2-cyclodextrin (EPPP\u03b2CD) have been characterized for the first time through a comprehensive suite of analytical methods. This study explores the therapeutic potential of EPPP\u03b2CD in modulating immune responses and accelerating the resolution of septic inflammation induced by chromium and vanadium ions in outbred male rats. The research highlights the significant impact of EPPP\u03b2CD on the dynamics of regulatory T lymphocytes (Tregs), notably causing a reduction in the CD4+CD25+ fractions at the onset of inflammation. This effect is attributed to the inhibition of Treg proliferation, which is crucial in hastening the resolution of inflammation. These findings underscore the potential of EPPP\u03b2CD as a promising therapeutic agent in controlling and mitigating inflammation mediated by heavy metal exposure, thereby offering a new avenue for the development of anti-inflammatory treatments.<\/jats:p>","DOI":"10.3390\/molecules29215135","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T09:57:36Z","timestamp":1730368656000},"page":"5135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel \u03b2-Cyclodextrin Complex as a Therapeutic Agent"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-6931","authenticated-orcid":false,"given":"Symbat","family":"Zhumakova","sequence":"first","affiliation":[{"name":"Laboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences, 106 Sh. Ualikhanov St., Almaty 050010, Kazakhstan"},{"name":"School of Chemical Engineering, Kazakh-British Technical University, 59 Tole bi St., Almaty 050000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliya","family":"Tokusheva","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Asfendiyarov Kazakh National Medical University, 94 Tole-bi St., Almaty 050000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-5646","authenticated-orcid":false,"given":"Tolganay","family":"Zharkynbek","sequence":"additional","affiliation":[{"name":"Laboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences, 106 Sh. Ualikhanov St., Almaty 050010, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Balabekova","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Asfendiyarov Kazakh National Medical University, 94 Tole-bi St., Almaty 050000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulev","family":"Koks","sequence":"additional","affiliation":[{"name":"Health Futures Institute, Murdoch University, 90 South St., Perth, WA 6150, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0079-4755","authenticated-orcid":false,"given":"Tulegen","family":"Seilkhanov","sequence":"additional","affiliation":[{"name":"Laboratory of Engineering Profile of NMR Spectroscopy, Sh. Ualikhanov Kokshetau State University, 76 Abai St., Kokshetau 020000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-8704","authenticated-orcid":false,"given":"Valery","family":"Dembitsky","sequence":"additional","affiliation":[{"name":"Centre for Applied Research, Innovation and Entrepreneurship, Lethbridge College, 3000 College Drive South, Lethbridge, AB T1K 1L6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Zazybin","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Kazakh-British Technical University, 59 Tole bi St., Almaty 050000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Aydemir","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Dicle University, Diyarbakir 21280, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-1559","authenticated-orcid":false,"given":"Ulan","family":"Kemelbekov","sequence":"additional","affiliation":[{"name":"Laboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences, 106 Sh. Ualikhanov St., Almaty 050010, Kazakhstan"},{"name":"South Kazakhstan Medical Academy, 1 Al-Farabi Square, Shymkent 160019, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-7728","authenticated-orcid":false,"given":"Gulgul","family":"Kairanbayeva","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Asfendiyarov Kazakh National Medical University, 94 Tole-bi St., Almaty 050000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-707X","authenticated-orcid":false,"given":"Valentina","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Synthetic and Natural Medicinal Compounds Chemistry, A.B. Bekturov Institute of Chemical Sciences, 106 Sh. 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