{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:40:22Z","timestamp":1782772822665,"version":"3.54.5"},"reference-count":56,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Cooperativa de Colombia","award":["INV3171"],"award-info":[{"award-number":["INV3171"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Sulfamerazine (SMR) is a drug used as an antibacterial agent in the treatment of some pathologies, such as bronchitis, prostatitis and urinary tract infections. Although this drug was developed in 1945 and, due to its toxicity, was partially displaced by penicillin, due to the current problem of bacterial resistance, compounds such as SMR have regained validity. In this context, the thermodynamic study of SMR in cosolvent mixtures of acetonitrile (MeCN) + ethanol (EtOH) at nine temperatures (278.15\u2013318.15 K) is presented. The solubility of SMR was determined by UV\u2013Vis spectrophotometry, following the guidelines of the shake-flask method. The solubility process was endothermic in all cases; thus, the minimum solubility was reached in pure EtOH at 278.15 K, and the maximum solubility was reached in pure MeCN at 318.15 K. Both the solution process and the mixing process were entropy-driven. On the other hand, the solubility data were modeled by using the van\u2019t Hoff\u2013Yalkowsky\u2013Roseman model, obtaining an overall average relative deviation of 3.9%. In general terms, it can be concluded that the solution process of SMR in {MeCN (1) + EtOH (2)} mixtures is thermodependent, favored by the entropy of the solution and mixture; additionally, the van\u2019t Hoff\u2013Yalkowsky\u2013Roseman model allows very good approximations to be obtained and is a simple model that starts from only four experimental data.<\/jats:p>","DOI":"10.3390\/molecules29225294","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:34:11Z","timestamp":1731324851000},"page":"5294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-701X","authenticated-orcid":false,"given":"Claudia Patricia","family":"Ortiz","sequence":"first","affiliation":[{"name":"Programa de Administraci\u00f3n en Seguridad y Salud en el Trabajo, Grupo de Investigaci\u00f3n en Seguridad y Salud en el Trabajo, Corporaci\u00f3n Universitaria Minuto de Dios-UNIMINUTO, Neiva 410001, Huila, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-9114","authenticated-orcid":false,"given":"Diego Ivan","family":"Caviedes-Rubio","sequence":"additional","affiliation":[{"name":"Programa de Ingenier\u00eda Civil, Grupo de Investigaci\u00f3n de Ingenier\u00edas UCC-Neiva, Facultad de Ingenier\u00eda, Universidad Cooperativa de Colombia, Sede Neiva, Calle 11 No. 1-51, Neiva 410001, Huila, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4008-7273","authenticated-orcid":false,"given":"Fleming","family":"Martinez","sequence":"additional","affiliation":[{"name":"Grupo de Investigaciones Farmac\u00e9utico-Fisicoqu\u00edmicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogot\u00e1, Carrera 30 No. 45-03, Bogot\u00e1 110321, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4835-9739","authenticated-orcid":false,"given":"Daniel Ricardo","family":"Delgado","sequence":"additional","affiliation":[{"name":"Programa de Ingenier\u00eda Civil, Grupo de Investigaci\u00f3n de Ingenier\u00edas UCC-Neiva, Facultad de Ingenier\u00eda, Universidad Cooperativa de Colombia, Sede Neiva, Calle 11 No. 1-51, Neiva 410001, Huila, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"key":"ref_1","first-page":"17","article-title":"The toxicity of sulfamerazine and sulfamethazine","volume":"81","author":"Schmidt","year":"1944","journal-title":"J. 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