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Technology Research Project of Jiangxi Provincial Department of Education","award":["GJJ2401302"],"award-info":[{"award-number":["GJJ2401302"]}]},{"name":"Science and Technology Research Project of Jiangxi Provincial Department of Education","award":["20212ACB216002"],"award-info":[{"award-number":["20212ACB216002"]}]},{"name":"Jiangxi Provincial Outstanding Youth Science Fund","award":["QD202108"],"award-info":[{"award-number":["QD202108"]}]},{"name":"Jiangxi Provincial Outstanding Youth Science Fund","award":["20232BAB213043"],"award-info":[{"award-number":["20232BAB213043"]}]},{"name":"Jiangxi Provincial Outstanding Youth Science Fund","award":["22367002"],"award-info":[{"award-number":["22367002"]}]},{"name":"Jiangxi Provincial Outstanding Youth Science Fund","award":["2023B1312"],"award-info":[{"award-number":["2023B1312"]}]},{"name":"Jiangxi Provincial Outstanding Youth Science Fund","award":["GJJ2401302"],"award-info":[{"award-number":["GJJ2401302"]}]},{"name":"Jiangxi Provincial Outstanding Youth Science Fund","award":["20212ACB216002"],"award-info":[{"award-number":["20212ACB216002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Pigeon pea (Cajanus cajan (L.) Millsp.) is a traditional Chinese medicinal plant widely utilized in folk medicine due to its significant pharmacological and nutritional properties. Cajaninstilbene acid (CSA), a stilbene compound derived from pigeon pea leaves, has been extensively investigated since the 1980s. A thorough understanding of CSA\u2019s mechanisms of action and its therapeutic effects on various diseases is crucial for developing novel therapeutic approaches. This paper presents an overview of recent research advancements concerning the biological activities and mechanisms of CSA and its derivatives up to February 2024. The review encompasses discussions on the in vivo metabolism of CSA and its derivatives, including antipathogenic micro-organisms activity, anti-tumor activity, systematic and organ protection activity (such as bone protection, cardiovascular protection, neuroprotection), anti-inflammatory activity, antioxidant activity, immune regulation as well as action mechanism of CSA and its derivatives. The most studied activities are antipathogenic micro-organisms activities. Additionally, the structure\u2013activity relationships of CSA and its derivatives as well as the total synthesis of CSA are explored, highlighting the potential for developing new pharmaceutical agents. This review aims to provide a foundation for future clinical applications of CSA and its derivatives.<\/jats:p>","DOI":"10.3390\/molecules29225440","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T07:51:15Z","timestamp":1732002675000},"page":"5440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review"],"prefix":"10.3390","volume":"29","author":[{"given":"Wen","family":"Hou","sequence":"first","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejun","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-5816","authenticated-orcid":false,"given":"Walter","family":"Luyten","sequence":"additional","affiliation":[{"name":"Department of Biology, Animal Physiology and Neurobiology Section, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Lai","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinuo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sishuang","family":"Kang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Dai","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-5519","authenticated-orcid":false,"given":"Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Lan","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Management, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116126","DOI":"10.1016\/j.ejmech.2024.116126","article-title":"Drug discovery and optimization based on the co-crystal structure of natural product with target","volume":"266","author":"Chen","year":"2024","journal-title":"Eur. 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