{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T02:10:14Z","timestamp":1783303814058,"version":"3.54.6"},"reference-count":34,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960755"],"award-info":[{"award-number":["81960755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160822"],"award-info":[{"award-number":["82160822"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["202305AS350001"],"award-info":[{"award-number":["202305AS350001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["202301AU070128"],"award-info":[{"award-number":["202301AU070128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Team Project of Yunnan Revitalization Talent Support Program","award":["81960755"],"award-info":[{"award-number":["81960755"]}]},{"name":"the Team Project of Yunnan Revitalization Talent Support Program","award":["82160822"],"award-info":[{"award-number":["82160822"]}]},{"name":"the Team Project of Yunnan Revitalization Talent Support Program","award":["202305AS350001"],"award-info":[{"award-number":["202305AS350001"]}]},{"name":"the Team Project of Yunnan Revitalization Talent Support Program","award":["202301AU070128"],"award-info":[{"award-number":["202301AU070128"]}]},{"name":"the Innovative Research Team of Yunnan Province Education Department, and Yunnan Fundamental Research Projects","award":["81960755"],"award-info":[{"award-number":["81960755"]}]},{"name":"the Innovative Research Team of Yunnan Province Education Department, and Yunnan Fundamental Research Projects","award":["82160822"],"award-info":[{"award-number":["82160822"]}]},{"name":"the Innovative Research Team of Yunnan Province Education Department, and Yunnan Fundamental Research Projects","award":["202305AS350001"],"award-info":[{"award-number":["202305AS350001"]}]},{"name":"the Innovative Research Team of Yunnan Province Education Department, and Yunnan Fundamental Research Projects","award":["202301AU070128"],"award-info":[{"award-number":["202301AU070128"]}]},{"name":"Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University","award":["81960755"],"award-info":[{"award-number":["81960755"]}]},{"name":"Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University","award":["82160822"],"award-info":[{"award-number":["82160822"]}]},{"name":"Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University","award":["202305AS350001"],"award-info":[{"award-number":["202305AS350001"]}]},{"name":"Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University","award":["202301AU070128"],"award-info":[{"award-number":["202301AU070128"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>One undescribed fatty glyceride (1), two unreported N-acetyldopamine dimers (2 and 3), and four known structurally diverse N-acetyldopamine dimers were isolated from adult Vespa velutina auraria Smith. Their structures were elucidated based on a comprehensive analysis of spectroscopic data, HRESIMS, and NMR calculations with ML_J_DP4, and the absolute configurations of 2 and 3 were determined via ECD calculations. Regarding their bioactivities, compounds 5 and 6 can inhibit the production of NO. Moreover, compounds 3, 5 and 7 showed stronger antioxidant activity than the positive control (VC) at 14 \u03bcg\/mL. A network pharmacology study was used to explore the potential bioactive mechanisms. In addition, a docking study of anti-inflammatory and antioxidative compounds was also performed.<\/jats:p>","DOI":"10.3390\/molecules29225445","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T07:51:15Z","timestamp":1732002675000},"page":"5445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti-Inflammatory and Antioxidative N-Acetyldopamine Dimers from Adult Vespa velutina auraria Smith"],"prefix":"10.3390","volume":"29","author":[{"given":"Chao-He","family":"Liu","sequence":"first","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Qing","family":"Pang","sequence":"additional","affiliation":[{"name":"Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd., Kunming 650106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Yu","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-4631","authenticated-orcid":false,"given":"Jing-Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Ma","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Huang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-7029","authenticated-orcid":false,"given":"Jia-Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai","family":"Xiao","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Tao","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1021\/acs.orglett.9b04044","article-title":"Detoxification of Plant Aromatic Abietanoids via Cleavage of the Benzene Ring into 11,12- Seco-diterpene Polyenes by a Specialist Insect of Leucosceptrum canum","volume":"22","author":"Guo","year":"2020","journal-title":"Org. 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