{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:14:32Z","timestamp":1787616872652,"version":"build-2736575974"},"reference-count":54,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Developing efficient and novel methodologies to construct a C\u2013C bond is highly important in both synthetic chemistry and pharmaceutical sciences. In recent years, the visible light-mediated desulfonylative transformation of sulfonyl compounds has emerged as a powerful tool for the synthesis of diverse C\u2013C bond. To emphasize their practical utility, many methodologies have been successfully applied in the modification of a variety of biologically active compounds which possess unprotected amide or hydroxy groups. In this review, we would like to summarize recent advances in C\u2013C bond formation via the visible light-mediated desulfonylation of sulfonyl chlorides, sulfinates, sulfonamides, sulfones, and sulfonylhydrazones. The reaction design, mechanism research, and the application of these protocols in the modification of biologically active compounds are presented. The challenges and future developments in this area are also discussed.<\/jats:p>","DOI":"10.3390\/molecules29235553","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T08:38:24Z","timestamp":1732523904000},"page":"5553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recent Advances in C\u2013C Bond Formation via Visible Light-Mediated Desulfonylation and Its Application in the Modification of Biologically Active Compounds"],"prefix":"10.3390","volume":"29","author":[{"given":"Xiaohong","family":"Xu","sequence":"first","affiliation":[{"name":"Chaozhou Institute for Drug Control, Chaozhou 521000, China"},{"name":"College of Pharmacy, Graduate School, Sun Yat-Sen University, Shenzhen 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chaozhou Institute for Drug Control, Chaozhou 521000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chaozhou Institute for Drug Control, Chaozhou 521000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1021\/acs.chemrev.5b00162","article-title":"Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents To Construct C-C Bonds","volume":"115","author":"Cherney","year":"2015","journal-title":"Chem. 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