{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:25:27Z","timestamp":1770729927379,"version":"3.49.0"},"reference-count":126,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2020-118303GB-I00"],"award-info":[{"award-number":["PID2020-118303GB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["SA076P20"],"award-info":[{"award-number":["SA076P20"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Junta de Castilla y Le\u00f3n","award":["PID2020-118303GB-I00"],"award-info":[{"award-number":["PID2020-118303GB-I00"]}]},{"name":"Junta de Castilla y Le\u00f3n","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Junta de Castilla y Le\u00f3n","award":["SA076P20"],"award-info":[{"award-number":["SA076P20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>2-Arylethylamines are presented in several natural bioactive compounds, as well as in nitrogen-containing drugs. Their ability to surpass the blood\u2013brain barrier makes this family of compounds of especial interest in medicinal chemistry. Asymmetric methodologies towards the synthesis of 2-arylethylamine motives are of great interest due to the challenges they may present. Thus, a concise metal-free review presenting recent advances in the asymmetric synthesis of 2-arylethylamines is presented, covering last-millennium studies, considering different methodologies towards the aforementioned motif, including chiral induction, organocatalysis, organophotocatalysis and enzymatic catalysis.<\/jats:p>","DOI":"10.3390\/molecules29235729","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T11:03:08Z","timestamp":1733310188000},"page":"5729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Asymmetric Synthesis of 2-Arylethylamines: A Metal-Free Review of the New Millennium"],"prefix":"10.3390","volume":"29","author":[{"given":"Alejandro","family":"Manchado","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. Ca\u00eddos, s\/n, 37008 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9100-3869","authenticated-orcid":false,"given":"\u00c1ngel","family":"Garc\u00eda-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. Ca\u00eddos, s\/n, 37008 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-8825","authenticated-orcid":false,"given":"Carlos T.","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. 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