{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:29:52Z","timestamp":1791228592446,"version":"4.1.0"},"reference-count":49,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"OOO \u201cNPF MATERIA MEDICA HOLDING\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Previous research has demonstrated that a combined magnetic field (CMF) plays a critical role in modifying the properties of aqueous solutions, leading to an increase in the luminol-enhanced chemiluminescence of neutrophils. Using this model, the distant interaction between aqueous solutions was demonstrated, and the role of a CMF in the regulation of this phenomenon was established. In the current study, highly diluted (HD) phorbol myristate acetate (PMA) solution (the donor) was incubated with aqueous ethanol (the acceptor), both in a CMF-generating device and under geomagnetic field (GMF), for 0, 20, and 60 min. After a 60 min incubation at a 0 cm distance with HD PMA under both GMF and CMF, acceptor samples added to neutrophils increased neutrophil chemiluminescence by approximately sevenfold. The ability of HD PMA, which had been incubated with an acceptor, to activate ROS production diminished within 60 min of observation. However, the HD PMA sample remained an effective donor for up to 6 days after preparation. At a 10 cm distance between the donor and acceptor, the activation of the acceptor did not occur. These findings provide new insights into the phenomenon of distant interaction of solutions, whose mechanisms are suggested to be related to the quantum electrodynamics of water molecular dynamic structures.<\/jats:p>","DOI":"10.3390\/molecules29235814","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T11:16:48Z","timestamp":1733743008000},"page":"5814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non-Contact Interaction Between Phorbol Myristate Acetate and Aqueous Alcohol Solutions Under Combined Magnetic Fields"],"prefix":"10.3390","volume":"29","author":[{"given":"Vadim V.","family":"Novikov","sequence":"first","affiliation":[{"name":"Institute of Cell Biophysics of the Russian Academy of Sciences, 142290 Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Yablokova","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics of the Russian Academy of Sciences, 142290 Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German O.","family":"Stepanov","sequence":"additional","affiliation":[{"name":"OOO \u00abNPF \u00abMateria Medica Holding\u00bb, 129272 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-8205","authenticated-orcid":false,"given":"Natalia N.","family":"Rodionova","sequence":"additional","affiliation":[{"name":"OOO \u00abNPF \u00abMateria Medica Holding\u00bb, 129272 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Tarasov","sequence":"additional","affiliation":[{"name":"OOO \u00abNPF \u00abMateria Medica Holding\u00bb, 129272 Moscow, Russia"},{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina V.","family":"Buravleva","sequence":"additional","affiliation":[{"name":"Faculty of Biology, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga I.","family":"Yablonskaya","sequence":"additional","affiliation":[{"name":"N.M. Emanuel Institute of Biochemical Physics RAS, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-7508","authenticated-orcid":false,"given":"Vladimir L.","family":"Voeikov","sequence":"additional","affiliation":[{"name":"Faculty of Biology, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/bem.2250060208","article-title":"Influence of constant magnetic fields on certain physiochemical properties of water","volume":"6","author":"Gonet","year":"1985","journal-title":"Bioelectromagnetics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/bem.2250120202","article-title":"Possible mechanism for the influence of weak magnetic fields on biological systems","volume":"12","author":"Lednev","year":"1991","journal-title":"Bioelectromagnetics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1016\/j.ces.2008.08.004","article-title":"Effects of Magnetic Field on the Crystallization of CaCO3 Using Permanent Magnets","volume":"63","author":"Tai","year":"2008","journal-title":"Chem. Eng. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cep.2010.12.005","article-title":"Effects of static magnetic field on water at kinetic condition","volume":"50","author":"Chibowski","year":"2011","journal-title":"Chem. Eng. Process. Process Intensif."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"215503","DOI":"10.1103\/PhysRevLett.91.215503","article-title":"Hydrogen Bonding in Water","volume":"91","author":"Chen","year":"2003","journal-title":"Phys. Rev. Lett."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molstruc.2009.08.037","article-title":"The Effects of Magnetic Fields on Water Molecular Hydrogen Bonds","volume":"938","author":"Cai","year":"2009","journal-title":"J. Mol. Struct."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"126121","DOI":"10.1016\/j.molliq.2024.126121","article-title":"Magnetic field modulation of confined water structure and transport in nanochannel","volume":"414","author":"Yan","year":"2024","journal-title":"J. Mol. Liq."},{"key":"ref_8","first-page":"351","article-title":"Effect of Weak Magnetic Fields on the Properties of Water and Ice","volume":"31","author":"Semikhina","year":"1988","journal-title":"J. Phys. Chem. Solids"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1081\/JBC-120003109","article-title":"Life in Zero Magnetic Field. IV. Investigation of Developmental Effects on Fruitfly Vision","volume":"21","author":"Creanga","year":"2002","journal-title":"Electromagn. Biol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/bem.20487","article-title":"Effect of Weak Combined Static and Extremely Low-Frequency Alternating Magnetic Fields on Tumor Growth in Mice Inoculated with the Ehrlich Ascites Carcinoma","volume":"30","author":"Novikov","year":"2009","journal-title":"Bioelectromagnetics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/15368378.2018.1471700","article-title":"Effect of Weak Combined Static and Extremely Low-Frequency Alternating Magnetic Fields on Spatial Memory and Brain Amyloid-\u03b2 in Two Animal Models of Alzheimer\u2019s Disease","volume":"37","author":"Bobkova","year":"2018","journal-title":"Electromagn. Biol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fesenko, E.E., Yablokova, E.V., and Novikov, V.V. (2024). Weak Magnetic Fields Regulate the Ability of High Dilutions of Water to Enhance ROS Production by Neutrophils. Appl. Sci., 14.","DOI":"10.3390\/app14083290"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Novikov, V.V., and Yablokova, E.V. (2022). Interaction between Highly Diluted Samples, Protein Solutions and Water in a Controlled Magnetic Field. Appl. Sci., 12.","DOI":"10.3390\/app12105185"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"24765","DOI":"10.1039\/D4RA02739F","article-title":"NADPH oxidase-dependent free radical generation and protein adduct formation in neutrophils","volume":"14","author":"Manoharan","year":"2024","journal-title":"RSC Adv."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/978-1-4684-8088-7_30","article-title":"The Respiratory Burst of Phagocytic Cells: Facts and Problems","volume":"Volume 141","author":"Rossi","year":"1982","journal-title":"Biochemistry and Function of Phagocytes"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Novikov, V.V., Yablokova, E.V., and Fesenko, E.E. (2020). The Role of Water in the Effect of Weak Combined Magnetic Fields on Production of Reactive Oxygen Species (ROS) by Neutrophils. Appl. Sci., 10.","DOI":"10.3390\/app10093326"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Penkov, N. (2021). Antibodies processed using high dilution technology distantly change structural properties of IFN\u03b3 aqueous solution. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111864"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Penkov, N., and Penkova, N. (2020). Analysis of Emission Infrared Spectra of Protein Solutions in Low Concentrations. Front. Phys., 8.","DOI":"10.3389\/fphy.2020.624779"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jerman, I., Ogrizek, L., Peri\u010dek Krape\u017e, V., and Jan, L. (2023). Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241511961"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/15368370500381620","article-title":"Electrical Transfer of Molecule Information into Water, Its Storage, and Bioeffects on Plants and Bacteria","volume":"24","author":"Jerman","year":"2005","journal-title":"Electromagn. Biol. Med."},{"key":"ref_21","unstructured":"Gorovoy, Y.M., and Penkov, N.V. (2023, January 13\u201315). Distant interaction of supramolecular systems of aqueous solutions as a process of transmission and reception of information and symmetry broadcast. Proceedings of the Conference \u201cPhysics of Aqueous Solutions\u201d, Moscow, Russia."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/15368378.2015.1036072","article-title":"Transduction of DNA information through water and electromagnetic waves","volume":"34","author":"Montagnier","year":"2015","journal-title":"Electromagn. Biol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.51910\/ijhdr.v7i24.300","article-title":"Electromagnetic Transference of Molecular Information in Garden Cress Germination","volume":"7","author":"Ruzic","year":"2008","journal-title":"Int. J. High Dilution Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15368378.2017.1347882","article-title":"Electromagnetic Information Transfer through Aqueous System","volume":"36","author":"Foletti","year":"2017","journal-title":"Electromagn. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"012007","DOI":"10.1088\/1742-6596\/306\/1\/012007","article-title":"DNA Waves and Water","volume":"306","author":"Montagnier","year":"2011","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Petrova, A., Tarasov, S., Gorbunov, E., Stepanov, G., Fartushnaya, O., Zubkov, E., Molodtsova, I., Boriskin, V., Zatykina, A., and Smirnov, A. (2024). Phenomenon of Post-Vibration Interactions. Symmetry, 16.","DOI":"10.3390\/sym16080958"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1142\/S0217979295000744","article-title":"QED coherence and the thermodynamics of water","volume":"9","author":"Arani","year":"1995","journal-title":"Int. J. Modern Phys. B"},{"key":"ref_28","unstructured":"Fels, D., Cifra, M., and Scholkmann, F. (2015). The origin and special role of coherent water in living systems. Fields of the Cell, Research Signpost."},{"key":"ref_29","first-page":"52","article-title":"Water respiration-the basis of the living state","volume":"1","author":"Voeikov","year":"2009","journal-title":"Water"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/15368370802708728","article-title":"Water and autocatalysis in living matter","volume":"28","author":"Giudice","year":"2009","journal-title":"Electromagn. Biol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"155115","DOI":"10.1103\/PhysRevB.92.155115","article-title":"Mesoscopic Structure Formation in Condensed Matter Due to Vacuum Fluctuations","volume":"92","author":"Sen","year":"2015","journal-title":"Phys. Rev. B"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/w2030566","article-title":"Water dynamics at the root of metamorphosis in living organisms","volume":"2","author":"Giudice","year":"2010","journal-title":"Water"},{"key":"ref_33","first-page":"115","article-title":"Liquids Prepared by Serially Diluting and Vigorously Shaking of Aqueous Solutions: Unveiling Effects of the Solute on Their Properties","volume":"10","author":"Yinnon","year":"2020","journal-title":"Water"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"012028","DOI":"10.1088\/1742-6596\/442\/1\/012028","article-title":"Coherent structures in liquid water close to hydrophilic surfaces","volume":"442","author":"Tedeschi","year":"2013","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_35","first-page":"48","article-title":"Domains Formation Mediated by Electromagnetic Fields in Very Dilute Aqueous Solutions: 2. Quantum Electrodynamic Analyses of Experimental Data on Strong Electrolyte Solutions","volume":"7","author":"Yinnon","year":"2015","journal-title":"Water"},{"key":"ref_36","first-page":"70","article-title":"Domains Formation Mediated by Electromagnetic Fields in Very Dilute Aqueous Solutions: 3. Quantum Electrodynamic Analyses of Experimental Data on Solutions of Weak Electrolytes and Non-Electrolytes","volume":"7","author":"Yinnon","year":"2015","journal-title":"Water"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1021\/acs.langmuir.0c00036","article-title":"Formation and Stability of Bulk Nanobubbles by Vibration","volume":"36","author":"Fang","year":"2020","journal-title":"Langmuir"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ces.2013.02.004","article-title":"Effects of Nanobubbles on the Physicochemical Properties of Water: The Basis for Peculiar Properties of Water Containing Nanobubbles","volume":"93","author":"Liu","year":"2013","journal-title":"Chem. Eng. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Gudkov, S.V., Penkov, N.V., Baimler, I.V., Lyakhov, G.A., Pustovoy, V.I., Simakin, A.V., Sarimov, R.M., and Scherbakov, I.A. (2020). Effect of Mechanical Shaking on the Physicochemical Properties of Aqueous Solutions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218033"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"14689","DOI":"10.1021\/acsomega.0c01444","article-title":"Shaking-Induced Aggregation and Flotation in Immunoglobulin Dispersions: Differences Between Water and Water\u2013Ethanol Mixtures","volume":"5","author":"Bunkin","year":"2020","journal-title":"ACS Omega"},{"key":"ref_41","unstructured":"Liboff, A.R. (2018). The ion cyclotron resonance hypothesis. Bioengineering and Biophysical Aspects of Electromagnetic Fields, CRC Press."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Liboff, A.R. (2005). The charge-to-mass ICR signature in weak ELF bioelectromagnetic effects. Advances in Electromagnetic Fields in Living Systems, Springer.","DOI":"10.1007\/0-387-24024-1_6"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3109\/15368378.2012.743908","article-title":"Bioelectromagnetic medicine: The role of resonance signaling","volume":"32","author":"Foletti","year":"2013","journal-title":"Electromagn. Biol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0168-1176(88)80002-8","article-title":"Excitation of the z-motion of ions in a cubic icr cell","volume":"82","year":"1988","journal-title":"Int. J. Mass Spec. Ion Proc."},{"key":"ref_45","first-page":"269","article-title":"Effect of Combined Static and Alternating Magnetic Fields on Ion Motion in a Solution: Theoretical Consideration and Experimental Results","volume":"25","author":"Zhadin","year":"2006","journal-title":"Electromagn. Biol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Giuliani, L., D\u2019Emilia, E., Grimaldi, S., Lisi, A., Bobkova, N., and Zhadin, M.N. (2009). Investigating the ICR Effect in a Zhadin\u2019s Cell. Int. J. Biomed. Sci IJBS, 5.","DOI":"10.59566\/IJBS.2009.5181"},{"key":"ref_47","first-page":"370","article-title":"Lorentz Force in Water: Evidence that Hydronium Cyclotron Resonance Enhances Polymorphism","volume":"34","author":"Giuliani","year":"2014","journal-title":"Electromagn. Biol. Med."},{"key":"ref_48","unstructured":"Stavroulakis, P. (2003). 2.4 Ion Cyclotron Resonance in Biological Systems: Experimental Evidence. Biological Effects of Electromagnetic Fields: Mechanisms, Modeling, Biological Effects, Therapeutic Effects, International Standards, Exposure Criteria, Springer."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/15368378.2019.1608234","article-title":"ION cyclotron resonance: Geomagnetic strategy for living systems?","volume":"38","author":"Liboff","year":"2019","journal-title":"Electromagn. Biol. Med."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/23\/5814\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:50:49Z","timestamp":1760115049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/23\/5814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":49,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["molecules29235814"],"URL":"https:\/\/doi.org\/10.3390\/molecules29235814","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]}}}