{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:40:46Z","timestamp":1780443646754,"version":"3.54.1"},"reference-count":77,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wroclaw Medical University","award":["SUBZ.D060.24.091"],"award-info":[{"award-number":["SUBZ.D060.24.091"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>(1) Background: The aim of the work was to investigate the influence of selected physico-chemical factors on the solubility and release rate of CT (cryptotanshinone) in alcohologels. (2) Methods: The alcohologels of methylcellulose (MC), hydroksyethylcellulose (HEC), polyacrylic acid (PA) and polyacrylic acid crosspolymer (PACP) with CT were prepared and\/or doped with native potato starch (SN) and modified citrate starches (SM2.5 and SM10). The analytical methods included evaluation of CT release profiles, Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and electrospray ionization mass spectrometry (ESI-MS), and scanning electron microscope (SEM) images were performed. (3) Results: The release and decomposition kinetics of CT in relation to the phosphate buffer solution (PBS) and methanol were observed. The amount of cryptotanshinone (CT) released into PBS was significantly lower (2.5%) compared to its release into methanol, where 22.5% of the CT was released into the model medium. The addition of SM2.5 to the alcohologel significantly increased the CT content to 70% in the alcohologel preparation containing NaOH (40%), and this enhanced stability was maintained for up to two months. The ATR-FTIR exhibited interactions between PA and 2-amino-2-methyl-1,3-propanediol (AMPD) as well as between PA and NaOH in case of the alcohologels. Moreover, it indicated the interaction between CT and NaOH. PXRD diffractograms confirmed the FTIR study. (4) Conclusions: The study observed the influence of a number of factors on the solubility and release rate of CT, as: alkalizers and their concentration, SM2.5 addition. The transition of CT in the presence of NaOH to the tanshinone V sodium (T-V sodium) form was suspected.<\/jats:p>","DOI":"10.3390\/molecules29245877","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T12:25:54Z","timestamp":1734006354000},"page":"5877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Co-Solvents, Modified Starch and Physical Parameters on the Solubility and Release Rate of Cryptotanshinone from Alcohologels"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-8906","authenticated-orcid":false,"given":"Justyna","family":"Kobry\u0144","sequence":"first","affiliation":[{"name":"Department of Physical Chemistry and Biophysics, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9124-3097","authenticated-orcid":false,"given":"Patryk","family":"Demski","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry and Biophysics, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-9971","authenticated-orcid":false,"given":"Bartosz","family":"Raszewski","sequence":"additional","affiliation":[{"name":"Department of Food Storage and Technology, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, Che\u0142mo\u0144skiego 37, 51-630 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-342X","authenticated-orcid":false,"given":"Tomasz","family":"Zi\u0119ba","sequence":"additional","affiliation":[{"name":"Department of Food Storage and Technology, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, Che\u0142mo\u0144skiego 37, 51-630 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-5998","authenticated-orcid":false,"given":"Witold","family":"Musia\u0142","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry and Biophysics, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nagappan, A., Kim, J.H., Jung, D.Y., and Jung, M.H. 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