{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:21:06Z","timestamp":1790727666176,"version":"4.1.0"},"reference-count":69,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the subprogram 010602 of the institutional project","award":["010602"],"award-info":[{"award-number":["010602"]}]},{"name":"the subprogram 010701 of the institutional project","award":["010701"],"award-info":[{"award-number":["010701"]}]},{"name":"the subprogram 011202 of the institutional project","award":["011202"],"award-info":[{"award-number":["011202"]}]},{"name":"Research and Innovation Project (24.80012.8007.01SE)","award":["24.80012.8007.01SE"],"award-info":[{"award-number":["24.80012.8007.01SE"]}]},{"name":"&quot;Young Researchers 2024-2025&quot; project (24.80012.5007.14TC)","award":["24.80012.5007.14TC"],"award-info":[{"award-number":["24.80012.5007.14TC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ten coordination compounds, [Cu(L1)Cl] (C1), [Cu(L1)NO3] (C2), [Cu(L2)Cl] (C3), [Cu(L2)NO3] (C4), [Cu(L3)Cl] (C5), [Cu(L3)NO3] (C6), [Cu(L4)NO3] (C7), [Cu(L4)Cl] (C8), [Cu(L5)Cl] (C9), and [Cu(L5)NO3] (C10), containing pyridine derivatives of N4-methoxyphenyl-thiosemicarbazones were synthesized and characterized. The molecular structure of four compounds was investigated using single crystal X-ray diffraction. Spectral analysis techniques such as FT-IR, 1H NMR, 13C NMR, elemental analysis, and molar conductivity were used for all the synthesized compounds. The tested synthesized compounds were evaluated for their anticancer activity and selectivity against a variety of cancer cell lines, including HL-60, LNCaP, MCF-7, HepG-2, K-562, HeLa, BxPC-3, RD, and MDCK normal cell line. Most compounds demonstrated selective anticancer activity superior to doxorubicin. Notably, all ligands showed high antiproliferative activity against HL-60 cells, with IC50 values between 0.01 and 0.06 \u00b5M and a selectivity index as high as 5000. Coordination of copper(II) with ligands HL1 and HL3 notably enhanced antiproliferative activity, lowering the IC50 to 0.03 \u00b5M. Additionally, the antioxidant activity of these compounds was assessed, revealing that all tested ligands and most coordination compounds exhibited greater antioxidant activity compared to Trolox, with some ligands showing activity up to 12.3 times higher. Toxicity studies on Daphnia magna indicated low toxicity for the ligands, generally less than doxorubicin, with LC50 values ranging from 13 to 90 \u00b5M, suggesting moderate toxicity. Conversely, the coordination complexes were more toxic, with LC50 values between 0.5 and 13 \u00b5M.<\/jats:p>","DOI":"10.3390\/molecules29246002","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:44:33Z","timestamp":1734677073000},"page":"6002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Novel Copper(II) Coordination Compounds Containing Pyridine Derivatives of N4-Methoxyphenyl-Thiosemicarbazones with Selective Anticancer Activity"],"prefix":"10.3390","volume":"29","author":[{"given":"Roman","family":"Rusnac","sequence":"first","affiliation":[{"name":"Laboratory of Advanced Materials in Biopharmaceutics and Technics, Institute of Chemistry, Moldova State University, MD-2009 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-892X","authenticated-orcid":false,"given":"Olga","family":"Garbuz","sequence":"additional","affiliation":[{"name":"Laboratory of Systematics and Molecular Phylogenetics, Institute of Zoology, Moldova State University, MD-2028 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Kravtsov","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Methods of Solid State Investigation \u201cTadeusz Malinowski\u201d, Institute of Applied Physics, Moldova State University, MD-2028 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Melnic","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Methods of Solid State Investigation \u201cTadeusz Malinowski\u201d, Institute of Applied Physics, Moldova State University, MD-2028 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorin","family":"Istrati","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University of Medicine and Pharmacy \u201cNicolae Testemitanu\u201d, MD-2004 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-3116","authenticated-orcid":false,"given":"Victor","family":"Tsapkov","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Materials in Biopharmaceutics and Technics, Institute of Chemistry, Moldova State University, MD-2009 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Poirier","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, CHU de Qu\u00e9bec Research Center, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelian","family":"Gulea","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Materials in Biopharmaceutics and Technics, Institute of Chemistry, Moldova State University, MD-2009 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Islam, B., Islam, I., Nath, N., Emran, T.B., Rahman, R., Sharma, R., and Matin, M.M. 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