{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:21:38Z","timestamp":1790709698109,"version":"4.1.0"},"reference-count":107,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation (NRF) of South Africa"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Benzylic C\u2013H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates. In this review, we highlight the synthesis of aromatic ketones via catalytic, electrochemical, and photochemical oxidation of alkylarenes using different catalysts and oxidants in the past 5 years. Additionally, we also discuss the synthesis of heterocyclic molecules using benzylic C\u2013H oxidation as a key step. These methods can potentially be used in medicinal, synthetic, and inorganic chemistry.<\/jats:p>","DOI":"10.3390\/molecules29246047","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T10:06:52Z","timestamp":1734948412000},"page":"6047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Benzylic C\u2013H Oxidation: Recent Advances and Applications in Heterocyclic Synthesis"],"prefix":"10.3390","volume":"29","author":[{"given":"Nonhlelo","family":"Majola","sequence":"first","affiliation":[{"name":"School of Chemistry and Physics, University of KwaZulu-Natal, Scottsville, Pietermaritzburg 3209, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-7677","authenticated-orcid":false,"given":"Vineet","family":"Jeena","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics, University of KwaZulu-Natal, Scottsville, Pietermaritzburg 3209, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s10562-017-2050-4","article-title":"Iodosobenzoic acid (IBA) catalysed benzylic and aromatic C\u2013H oxidations","volume":"147","author":"Bindu","year":"2017","journal-title":"Catal. 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