{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T07:58:57Z","timestamp":1782719937757,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development Project Foundation of Hebei Province","award":["21372502D"],"award-info":[{"award-number":["21372502D"]}]},{"name":"Key Research and Development Project Foundation of Hebei Province","award":["H2023206068"],"award-info":[{"award-number":["H2023206068"]}]},{"name":"Natural Science Foundation of Hebei Province of China","award":["21372502D"],"award-info":[{"award-number":["21372502D"]}]},{"name":"Natural Science Foundation of Hebei Province of China","award":["H2023206068"],"award-info":[{"award-number":["H2023206068"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Background: Angelicae Dahuricae Radix (ADR) is used as both a traditional Chinese medicine and a food ingredient in China and East Asian countries. ADR is generally sun-dried post-harvest but is sometimes sulfur-fumigated to prevent decay and rot. Although there are some studies on the effect of sulfur fumigation on ADR, they are not comprehensive. Methods: This study used HPLC fingerprinting, matrix-assisted laser desorption\/ionization mass spectrometry imaging (MALDI-MSI), in vitro anti-inflammatory assays, and metabolite analysis in blood based on UPLC-MS\/MS to assess the impact of sulfur fumigation on the active ingredients of ADR. Results: There were significant decreases in specific coumarins and amino acids, particularly byakangelicol, oxypeucedanin, L-proline, and L-arginine, following sulfur fumigation. Among the 185 metabolites in blood, there were 30 different compounds, and oxypeucedanin was the most obvious component to decrease after sulfur fumigation. ADR showed anti-inflammatory activity regardless of sulfur fumigation. However, the effects on the production of cytokines in LPS-induced RAW264.7 cells were different. Conclusions: Chemometric analysis and in vitro anti-inflammatory studies suggested that byakangelicol and oxypeucedanin could serve as potential quality markers for identifying sulfur-fumigated ADR. These findings provide a chemical basis for comprehensive safety and functional evaluations of sulfur-fumigated ADR, supporting further research in this field.<\/jats:p>","DOI":"10.3390\/molecules30010022","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:27:46Z","timestamp":1735154866000},"page":"22","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of Sulfur Fumigation on Angelicae Dahuricae Radix: Insights from Chemical Profiles, MALDI-MSI and Anti-Inflammatory Activities"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0941-6145","authenticated-orcid":false,"given":"Changshun","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"},{"name":"NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050227, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3332-0540","authenticated-orcid":false,"given":"Yongli","family":"Liu","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050227, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5681-912X","authenticated-orcid":false,"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050227, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-7450","authenticated-orcid":false,"given":"Zhenhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Shimadzu China Innovation Center, Shimadzu China, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6319-4569","authenticated-orcid":false,"given":"Zhenxia","family":"Zhao","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050227, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhu","family":"Sun","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050227, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1719-0449","authenticated-orcid":false,"given":"Jian","family":"Su","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Quality Monitoring and Evaluation of Traditional Chinese Medicine (Chinese Materia Medica), Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050227, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3961-5522","authenticated-orcid":false,"given":"Ding","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Deng, A.-P., Kang, C.-Z., Kang, L.-P., Lyu, C.-G., Zhang, W.-J., Wang, H.-Y., Huang, L.-Q., Zhan, Z.-L., and Guo, L.-P. 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