{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:55:32Z","timestamp":1771887332312,"version":"3.50.1"},"reference-count":113,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liao Cheng University Excellent Textbook Project","award":["319260306"],"award-info":[{"award-number":["319260306"]}]},{"name":"Liao Cheng University Excellent Textbook Project","award":["WFKF (2023)002"],"award-info":[{"award-number":["WFKF (2023)002"]}]},{"name":"Liao Cheng University Excellent Textbook Project","award":["2023YFS0359"],"award-info":[{"award-number":["2023YFS0359"]}]},{"name":"State Key Laboratory of Efficient Utilization for Low Grade Phosphate Rock and Its Associated Resources","award":["319260306"],"award-info":[{"award-number":["319260306"]}]},{"name":"State Key Laboratory of Efficient Utilization for Low Grade Phosphate Rock and Its Associated Resources","award":["WFKF (2023)002"],"award-info":[{"award-number":["WFKF (2023)002"]}]},{"name":"State Key Laboratory of Efficient Utilization for Low Grade Phosphate Rock and Its Associated Resources","award":["2023YFS0359"],"award-info":[{"award-number":["2023YFS0359"]}]},{"name":"Sichuan Science and Technology Program","award":["319260306"],"award-info":[{"award-number":["319260306"]}]},{"name":"Sichuan Science and Technology Program","award":["WFKF (2023)002"],"award-info":[{"award-number":["WFKF (2023)002"]}]},{"name":"Sichuan Science and Technology Program","award":["2023YFS0359"],"award-info":[{"award-number":["2023YFS0359"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Hydrogen-bonded organic framework (HOF) materials are typically formed by the self-assembly of small organic units (synthons) with specific functional groups through hydrogen bonding or other interactions. HOF is commonly used as an electrolyte for batteries. Well-designed HOF materials can enhance the proton exchange rate, thereby boosting battery performance. This paper reviews recent advancements in the continuous synthesis of HOF synthons, in the continuous synthesis of HOF\u2019s unit small molecules enabling the multi-step, rapid, and in situ synthesis of synthons, such as carboxylic acid, diaminotriazine (DAT), urea, guanidine, imidazole, pyrazole, pyridine, thiazole, triazole, and tetrazole, with online monitoring. Continuous flow reactors facilitate fast chemical reactions and precise microfluidic control, offering superior reaction speed, product yield, and selectivity compared to batch processes. Integrating the continuous synthesis of synthons with the construction of HOF materials on a single platform is essential for achieving low-cost, safe, and efficient processing, especially for reactions involving toxic, flammable, or explosive substances.<\/jats:p>","DOI":"10.3390\/molecules30010041","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T21:13:18Z","timestamp":1735247598000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-169X","authenticated-orcid":false,"given":"Xingjun","family":"Yao","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanmiao","family":"Wen","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Taishan University, Tai\u2019an 271021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiulin","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Shang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2000265","DOI":"10.1002\/adom.202000265","article-title":"Supramolecular artificial light-harvesting systems with aggregation-Induced emission","volume":"8","author":"Hu","year":"2020","journal-title":"Adv. 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