{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:49:13Z","timestamp":1792622953854,"version":"4.5.0"},"reference-count":204,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The gut\u2013brain axis (GBA) is a complex communication network connecting the gastrointestinal tract (GIT) and the central nervous system (CNS) through neuronal, endocrine, metabolic, and immune pathways. Omega-3 (n-3) fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are crucial food components that may modulate the function of this axis through molecular mechanisms. Derived mainly from marine sources, these long-chain polyunsaturated fatty acids are integral to cell membrane structure, enhancing fluidity and influencing neurotransmitter function and signal transduction. Additionally, n-3 fatty acids modulate inflammation by altering eicosanoid production, reducing proinflammatory cytokines, and promoting anti-inflammatory mediators. These actions help preserve the integrity of cellular barriers like the intestinal and blood\u2013brain barriers. In the CNS, EPA and DHA support neurogenesis, synaptic plasticity, and neurotransmission, improving cognitive functions. They also regulate the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis by reducing excessive cortisol production, associated with stress responses and mental health disorders. Furthermore, n-3 fatty acids influence the composition and function of the gut microbiota, promoting beneficial bacterial populations abundance that contribute to gut health and improve systemic immunity. Their multifaceted roles within the GBA underscore their significance in maintaining homeostasis and supporting mental well-being.<\/jats:p>","DOI":"10.3390\/molecules30010071","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T13:37:51Z","timestamp":1735738671000},"page":"71","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Molecular Mechanisms Linking Omega-3 Fatty Acids and the Gut\u2013Brain Axis"],"prefix":"10.3390","volume":"30","author":[{"given":"Anna","family":"Zinkow","sequence":"first","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences\u2014SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-4948","authenticated-orcid":false,"given":"Wojciech","family":"Grodzicki","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences\u2014SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-2679","authenticated-orcid":false,"given":"Malwina","family":"Czerwi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences\u2014SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8069-6356","authenticated-orcid":false,"given":"Katarzyna","family":"Dziendzikowska","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences\u2014SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-01846-6_1","article-title":"Functional Morphology of the Gastrointestinal Tract","volume":"337","author":"Shen","year":"2009","journal-title":"Mol. Mech. Bact. Infect. Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/scientificamerican1016-30","article-title":"A Look Inside the Brain","volume":"315","author":"Deisseroth","year":"2016","journal-title":"Sci. Am."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lu, S., Zhao, Q., Guan, Y., Sun, Z., Li, W., Guo, S., and Zhang, A. (2024). The Communication Mechanism of the Gut-Brain Axis and Its Effect on Central Nervous System Diseases: A Systematic Review. Biomed. Pharmacother., 178.","DOI":"10.1016\/j.biopha.2024.117207"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Morys, J., Ma\u0142ecki, A., and Nowacka-Chmielewska, M. (2024). Stress and the Gut-Brain Axis: An Inflammatory Perspective. Front. Mol. Neurosci., 17.","DOI":"10.3389\/fnmol.2024.1415567"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","article-title":"Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits","volume":"9","author":"Shahidi","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liput, K.P., Lepczy\u0144ski, A., Og\u0142uszka, M., Nawrocka, A., Po\u0142awska, E., Grzesiak, A., \u015alaska, B., Pareek, C.S., Czarnik, U., and Pierzcha\u0142a, M. (2021). Effects of Dietary n\u20133 and n\u20136 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136965"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/advances\/nmac016","article-title":"Impact of \u03b1-Linolenic Acid, the Vegetable \u03c9-3 Fatty Acid, on Cardiovascular Disease and Cognition","volume":"13","author":"Fleming","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chandola, H.M., and Tanna, I. (2014). Role of Omega-3 Fatty Acids in Brain and Neurological Health with Special Reference to Clinical Depression. Omega-3 Fatty Acids in Brain and Neurological Health, Academic Press.","DOI":"10.1016\/B978-0-12-410527-0.00014-4"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Drobner, T., Braun, T.S., Kiehntopf, M., Schlattmann, P., Lorkowski, S., and Dawczynski, C. (2023). Evaluation of Influencing Factors on Metabolism of Land-Based n-3 Poly Unsaturated Fatty Acids\u2014The KoALA Study. Nutrients, 15.","DOI":"10.3390\/nu15204461"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ijdevneu.2009.12.001","article-title":"Long-Term Effects of High Lipid and High Energy Diet on Serum Lipid, Brain Fatty Acid Composition, and Memory and Learning Ability in Mice","volume":"28","author":"Yu","year":"2010","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The Gut Microbiota\u2013Brain Axis in Behaviour and Brain Disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_13","first-page":"203","article-title":"The Gut-Brain Axis: Interactions between Enteric Microbiota, Central and Enteric Nervous Systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10253890.2018.1470238","article-title":"Role of Glucocorticoid Negative Feedback in the Regulation of HPA Axis Pulsatility","volume":"21","author":"Gjerstad","year":"2018","journal-title":"Stress"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1136\/gut.2006.117176","article-title":"Probiotic Treatment of Rat Pups Normalises Corticosterone Release and Ameliorates Colonic Dysfunction Induced by Maternal Separation","volume":"56","author":"Gareau","year":"2007","journal-title":"Gut"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Liang, S., Wu, X., and Jin, F. (2018). Gut-Brain Psychology: Rethinking Psychology from the Microbiota\u2013Gut\u2013Brain Axis. Front. Integr. Neurosci., 12.","DOI":"10.3389\/fnint.2018.00033"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105383","DOI":"10.1016\/j.micpath.2021.105383","article-title":"Microbial Pathogenesis in Inflammatory Bowel Diseases","volume":"163","author":"Kumar","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/17474124.2017.1343143","article-title":"The Intestinal Barrier: A Fundamental Role in Health and Disease","volume":"11","author":"Vancamelbeke","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12974-019-1434-3","article-title":"Impact of Microbiota on Central Nervous System and Neurological Diseases: The Gut-Brain Axis","volume":"16","author":"Ma","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cell.2016.01.013","article-title":"Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans","volume":"164","author":"Sender","year":"2016","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.biopsych.2014.07.012","article-title":"Obese-Type Gut Microbiota Induce Neurobehavioral Changes in the Absence of Obesity","volume":"77","author":"Salbaum","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Chen, Y., Xu, J., and Chen, Y. (2021). Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. Nutrients, 13.","DOI":"10.3390\/nu13062099"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1038\/533S104a","article-title":"Microbiome: Bacterial Broadband","volume":"533","author":"Eisenstein","year":"2016","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","article-title":"Global, Regional, and National Burden of Alzheimer\u2019s Disease and Other Dementias, 1990\u20132016: A Systematic Analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Nichols","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host Microbiota Constantly Control Maturation and Function of Microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Di Tommaso, N., Gasbarrini, A., and Ponziani, F.R. (2021). Intestinal Barrier in Human Health and Disease. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182312836"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jcmgh.2021.02.007","article-title":"Regulation of Intestinal Barrier Function by Microbial Metabolites","volume":"11","author":"Ghosh","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","article-title":"The Blood-Brain Barrier: An Overview: Structure, Regulation, and Clinical Implications","volume":"16","author":"Ballabh","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1848212","DOI":"10.1080\/21688370.2020.1848212","article-title":"Cell-Cell Junctions: Structure and Regulation in Physiology and Pathology","volume":"9","author":"Adil","year":"2021","journal-title":"Tissue Barriers"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0301-0082(02)00128-4","article-title":"Junctional Complexes of the Blood-Brain Barrier: Permeability Changes in Neuroinflammation","volume":"68","author":"Petty","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2015.01.002","article-title":"Anatomy and Physiology of the Blood-Brain Barrier","volume":"38","author":"Serlin","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Guix\u00e0-Gonz\u00e1lez, R., Javanainen, M., G\u00f3mez-Soler, M., Cordobilla, B., Domingo, J.C., Sanz, F., Pastor, M., Ciruela, F., Martinez-Seara, H., and Selent, J. (2016). Membrane Omega-3 Fatty Acids Modulate the Oligomerisation Kinetics of Adenosine A2A and Dopamine D2 Receptors. Sci. Rep., 6.","DOI":"10.1038\/srep19839"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12035-011-8200-6","article-title":"Endogenous Signaling by Omega-3 Docosahexaenoic Acid-Derived Mediators Sustains Homeostatic Synaptic and Circuitry Integrity","volume":"44","author":"Bazan","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/mnfr.200900201","article-title":"Dietary \u03c9-3 Fatty Acid Supplementation for Optimizing Neuronal Structure and Function","volume":"54","author":"Heinrichs","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/nure.12088","article-title":"Omega-3 Polyunsaturated Fatty Acids and Chronic Stress-Induced Modulations of Glutamatergic Neurotransmission in the Hippocampus","volume":"72","author":"Hennebelle","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3945\/ajcn.2009.28549","article-title":"Docosahexaenoic Acid Supplementation Increases Prefrontal Cortex Activation during Sustained Attention in Healthy Boys: A Placebo-Controlled, Dose-Ranging, Functional Magnetic Resonance Imaging Study","volume":"91","author":"McNamara","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Dyall, S.C. (2015). Long-Chain Omega-3 Fatty Acids and the Brain: A Review of the Independent and Shared Effects of EPA, DPA and DHA. Front. Aging Neurosci., 7.","DOI":"10.3389\/fnagi.2015.00052"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0361-9230(01)00551-2","article-title":"The Relationship between Age and the Fatty Acid Composition of Cerebral Cortex and Erythrocytes in Human Subjects","volume":"56","author":"Carver","year":"2001","journal-title":"Brain Res. Bull."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.bbamem.2013.12.016","article-title":"Membrane Lipid Modifications and Therapeutic Effects Mediated by Hydroxydocosahexaenoic Acid on Alzheimer\u2019s Disease","volume":"1838","author":"Torres","year":"2014","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"de Santis, A., Scoppola, E., Ottaviani, M.F., Koutsioubas, A., Barnsley, L.C., Paduano, L., D\u2019Errico, G., and Krauss, I.R. (2022). Order vs. Disorder: Cholesterol and Omega-3 Phospholipids Determine Biomembrane Organization. Int. J. Mol. Sci., 2.","DOI":"10.3390\/ijms23105322"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1039\/D0SM01549K","article-title":"Not Just a Fluidifying Effect: Omega-3 Phospholipids Induce Formation of Non-Lamellar Structures in Biomembranes","volume":"16","author":"Vitiello","year":"2020","journal-title":"Soft Matter"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0022-2275(20)41397-5","article-title":"Cellular Interactions between N-6 and n-3 Fatty Acids: A Mass Analysis of Fatty Acid Elongation\/Desaturation, Distribution among Complex Lipids, and Conversion to Eicosanoids","volume":"33","author":"Rubin","year":"1992","journal-title":"J. Lipid Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/MOL.0000000000000443","article-title":"Membrane Lipids and Cell Signaling","volume":"28","author":"Sunshine","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/ajpcell.00458.2010","article-title":"Membrane Cholesterol Modulates the Fluid Shear Stress Response of Polymorphonuclear Leukocytes via Its Effects on Membrane Fluidity","volume":"301","author":"Zhang","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1098\/rsif.2019.0803","article-title":"Criticality of Plasma Membrane Lipids Reflects Activation State of Macrophage Cells","volume":"17","author":"Cammarota","year":"2020","journal-title":"J. R. Soc. Interface"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1086S","DOI":"10.1093\/jn\/126.suppl_4.1086S","article-title":"Antagonistic Effects of Dietary Arachidonic Acid and N-3 Polyunsaturated Fatty Acids","volume":"126","author":"Whelan","year":"1996","journal-title":"J. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.biochi.2009.01.008","article-title":"Polyunsaturated Fatty Acids and Inflammatory Processes: New Twists in an Old Tale","volume":"91","author":"Calder","year":"2009","journal-title":"Biochimie"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1038\/s41380-021-01160-8","article-title":"Omega-3 Polyunsaturated Fatty Acids Protect against Inflammation through Production of LOX and CYP450 Lipid Mediators: Relevance for Major Depression and for Human Hippocampal Neurogenesis","volume":"26","author":"Borsini","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1194\/jlr.M047357","article-title":"Dietary Omega-3 Fatty Acids Modulate the Eicosanoid Profile in Man Primarily via the CYP-Epoxygenase Pathway","volume":"55","author":"Fischer","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ceccarini, M.R., Ceccarelli, V., Codini, M., Fettucciari, K., Calvitti, M., Cataldi, S., Albi, E., Vecchini, A., and Beccari, T. (2022). The Polyunsaturated Fatty Acid EPA, but Not DHA, Enhances Neurotrophic Factor Expression through Epigenetic Mechanisms and Protects against Parkinsonian Neuronal Cell Death. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232416176"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1073\/pnas.1200189109","article-title":"Omega-3 Fatty Acids Cause Dramatic Changes in TLR4 and Purinergic Eicosanoid Signaling","volume":"109","author":"Norris","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/ajcn\/63.2.208","article-title":"Rapid Modulation of Lung and Liver Macrophage Phospholipid Fatty Acids in Endotoxemic Rats by Continuous Enteral Feeding with N-3 and y-Linolenic Fatty Acids","volume":"63","author":"Palombo","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100113","DOI":"10.1016\/j.jlr.2021.100113","article-title":"Omega-3 versus Omega-6 Fatty Acid Availability Is Controlled by Hydrophobic Site Geometries of Phospholipase A2s","volume":"62","author":"Hayashi","year":"2021","journal-title":"J. Lipid Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/jcp.20678","article-title":"Effect of Arachidonic and Eicosapentaenoic Acid Metabolism on RAW 264.7 Macrophage Proliferation","volume":"208","author":"Nieves","year":"2006","journal-title":"J. Cell Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.atherosclerosis.2020.11.018","article-title":"EPA and DHA Differentially Modulate Monocyte Inflammatory Response in Subjects with Chronic Inflammation in Part via Plasma Specialized Pro-Resolving Lipid Mediators: A Randomized, Double-Blind, Crossover Study","volume":"316","author":"So","year":"2021","journal-title":"Atherosclerosis"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/ajcn\/83.2.331","article-title":"Dose-Related Effects of Eicosapentaenoic Acid on Innate Immune Function in Healthy Humans: A Comparison of Young and Older Men","volume":"83","author":"Rees","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/nu2030355","article-title":"Omega-3 Fatty Acids and Inflammatory Processes","volume":"2","author":"Calder","year":"2010","journal-title":"Nutrients"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1753-4887.2010.00287.x","article-title":"Fatty Acids from Fish: The Anti-Inflammatory Potential of Long-Chain Omega-3 Fatty Acids","volume":"68","author":"Wall","year":"2010","journal-title":"Nutr. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.biochi.2020.08.015","article-title":"Eicosapentaenoic and Docosahexaenoic Acid Derived Specialised Pro-Resolving Mediators: Concentrations in Humans and the Effects of Age, Sex, Disease and Increased Omega-3 Fatty Acid Intake","volume":"178","author":"Calder","year":"2020","journal-title":"Biochimie"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Calder, P.C. (2024). Dietary Fatty Acids, Lipid Mediators, Immunity, and Inflammation. Functional Dietary Lipids: Food Formulation, Consumer Issues, and Innovation for Health, Woodhead Publishing. [2nd ed.].","DOI":"10.1016\/B978-0-443-15327-3.00003-3"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0006-2952(97)00497-8","article-title":"\u03b1- and \u03b2- Alkyl-Substituted Eicosapentaenoic Acids: Incorporation into Phospholipids and Effets on Prostaglandin H Synthase and 5-Lipoxygenase","volume":"55","author":"Larsen","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"22254","DOI":"10.1074\/jbc.M703169200","article-title":"Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-Derived versus Eicosapentaenoic Acid-Derived Substrates and Products","volume":"282","author":"Wada","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3945\/ajcn.116.131896","article-title":"A Randomized, Crossover, Head-to-Head Comparison of Eicosapentaenoic Acid and Docosahexaenoic Acid Supplementation to Reduce Inflammation Markers in Men and Women: The Comparing EPA to DHA (ComparED) Study","volume":"104","author":"Allaire","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Liu, J.-Y. (2022). Editorial: Eicosanoids and Cytokines: Resolution of Inflammation. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.978331"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.nut.2007.11.005","article-title":"Dietary Eicosapentaenoic Acid and Docosahexaenoic Acid Equally Incorporate as Decosahexaenoic Acid but Differ in Inflammatory Effects","volume":"24","author":"Sierra","year":"2008","journal-title":"Nutrition"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Skelly, D.T., Hennessy, E., Dansereau, M.A., and Cunningham, C. (2013). A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1\u0392, TNF-\u03b1 and IL-6 Challenges in C57BL\/6 Mice. PLoS ONE, 8.","DOI":"10.1371\/annotation\/90c76048-2edd-4315-8404-4d9d8cbd411e"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuropharm.2014.10.027","article-title":"Neuromodulatory Properties of Inflammatory Cytokines and Their Impact on Neuronal Excitability","volume":"96","author":"Vezzani","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0893-133X(99)00166-9","article-title":"Synergistic Effects of Interleukin-1, Interleukin-6, and Tumor Necrosis Factor-: Central Monoamine, Corticosterone, and Behavioral Variations","volume":"22","author":"Brebner","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7664","DOI":"10.1007\/s12035-019-1567-5","article-title":"Interferon-\u03b3 Potentiates \u03b1-Synuclein-Induced Neurotoxicity Linked to Toll-like Receptors 2 and 3 and Tumor Necrosis Factor-\u03b1 in Murine Astrocytes","volume":"56","author":"Wang","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.3168\/jds.2013-7696","article-title":"Hypothalamic-Pituitary-Adrenal Axis Activation and Immune Regulation in Heat-Stressed Sheep after Supplementation with Polyunsaturated Fatty Acids","volume":"97","author":"Caroprese","year":"2014","journal-title":"J. Dairy Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1900824","DOI":"10.1002\/mnfr.201900824","article-title":"Immuno-Resolving Ability of Resolvins, Protectins, and Maresins Derived from Omega-Fatty Acids in Metabolic Syndrome","volume":"64","author":"Kwon","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/mnfr.201300405","article-title":"Impact of EPA Ingestion on COX- and LOX-Mediated Eicosanoid Synthesis in Skin with and without a pro-Inflammatory UVR Challenge\u2014Report of a Randomised Controlled Study in Humans","volume":"58","author":"Pilkington","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ferreira, I., Falcato, F., Bandarra, N., and Rauter, A.P. (2022). Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in Inflammation. Molecules, 27.","DOI":"10.3390\/molecules27051677"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1007\/s00134-008-1142-4","article-title":"Anti-Inflammatory Properties of Omega-3 Fatty Acids in Critical Illness: Novel Mechanisms and an Integrative Perspective","volume":"34","author":"Singer","year":"2008","journal-title":"Intensive Care Med."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Z\u00fa\u00f1iga, J., Cancino, M., Medina, F., Varela, P., Vargas, R., Tapia, G., Videla, L.A., and Fern\u00e1ndez, V. (2011). N-3 PUFA Supplementation Triggers PPAR-\u03b1 Activation and PPAR-\u03b1\/NF-\u039aB Interaction: Anti-Inflammatory Implications in Liver Ischemia-Reperfusion Injury. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028502"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/mnfr.201300458","article-title":"N-3 Long-Chain PUFA Supplementation Prevents High Fat Diet Induced Mouse Liver Steatosis and Inflammation in Relation to PPAR-\u03b1 Upregulation and NF-\u039aB DNA Binding Abrogation","volume":"58","author":"Tapia","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2016.12.018","article-title":"DHA-Derived Oxylipins, Neuroprostanes and Protectins, Differentially and Dose-Dependently Modulate the Inflammatory Response in Human Macrophages: Putative Mechanisms through PPAR Activation","volume":"103","author":"Bosviel","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.biopha.2018.01.036","article-title":"Upregulation of PPAR-\u03b3 Mediates the Renoprotective Effect of Omega-3 PUFA and Ferulic Acid in Gentamicin-Intoxicated Rats","volume":"99","author":"Khedr","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.jnutbio.2011.09.005","article-title":"PPAR\u03b3 as a Molecular Target of EPA Anti-Inflammatory Activity during TNF-\u03b1-Impaired Skeletal Muscle Cell Differentiation","volume":"23","author":"Magee","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Campanari, D.D., Cipriano, U.G., Fraga-Silva, T.F.D.C., Ramalho, L.N.Z., Ovidio, P.P., Jord\u00e3o J\u00fanior, A.A., Bonato, V.L.D., and Ferriolli, E. (2024). Effect of Dietary Supplementation with Omega-3 Fatty Acid on the Generation of Regulatory T Lymphocytes and on Antioxidant Parameters and Markers of Oxidative Stress in the Liver Tissue of IL\u221210 Knockout Mice. Nutrients, 16.","DOI":"10.3390\/nu16050634"},{"key":"ref_81","first-page":"589","article-title":"Docosahexaenoic and Eicosapentaenoic Acids Inhibit In vitro Human Endothelial Cell Production of Interleukin-6","volume":"400","author":"Khalfoun","year":"1997","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jnutbio.2009.02.008","article-title":"Anti-Inflammatory Effects of EPA and DHA Are Dependent upon Time and Dose-Response Elements Associated with LPS Stimulation in THP-1-Derived Macrophages","volume":"21","author":"Mullen","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Wierenga, K.A., Riemers, F.M., Westendorp, B., Harkema, J.R., and Pestka, J.J. (2022). Single Cell Analysis of Docosahexaenoic Acid Suppression of Sequential LPS-Induced Proinflammatory and Interferon-Regulated Gene Expression in the Macrophage. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.993614"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jnutbio.2006.04.003","article-title":"Docosahexaenoic Acid Induces an Anti-Inflammatory Profile in Lipopolysaccharide-Stimulated Human THP-1 Macrophages More Effectively than Eicosapentaenoic Acid","volume":"18","author":"Weldon","year":"2007","journal-title":"J. Nutr. Biochem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid Storm in Infection and Inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jnutbio.2010.06.009","article-title":"Omega-3 Fatty Acids Attenuate Dendritic Cell Function via NF-\u039aB Independent of PPAR\u03b3","volume":"22","author":"Draper","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating Cell-Signalling Pathways with NF-\u039aB and IKK Function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Downton, P., Bagnall, J.S., England, H., Spiller, D.G., Humphreys, N.E., Jackson, D.A., Paszek, P., White, M.R.H., and Adamson, A.D. (2023). Overexpression of I\u03baB\u237a Modulates NF-\u039aB Activation of Inflammatory Target Gene Expression. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1187187"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Adelaja, A., and Hoffmann, A. (2019). Signaling Crosstalk Mechanisms That May Fine-Tune Pathogen-Responsive NF\u03baB. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00433"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u039aB Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s12031-011-9496-4","article-title":"Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood-Brain Barrier in a Focal Cerebral Ischemic Insult","volume":"44","author":"Jiao","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuro.2010.10.004","article-title":"Assessments of Tight Junction Proteins Occludin, Claudin 5 and Scaffold Proteins ZO1 and ZO2 in Endothelial Cells of the Rat Blood-Brain Barrier: Cellular Responses to Neurotoxicants Malathion and Lead Acetate","volume":"32","author":"Balbuena","year":"2011","journal-title":"Neurotoxicology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.clnu.2012.03.003","article-title":"N-3 PUFAs Attenuate Ischemia\/Reperfusion Induced Intestinal Barrier Injury by Activating I-FABP-PPAR\u03b3 Pathway","volume":"31","author":"Wang","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nbd.2016.02.020","article-title":"Omega-3 Polyunsaturated Fatty Acids Mitigate Blood-Brain Barrier Disruption after Hypoxic-Ischemic Brain Injury","volume":"91","author":"Zhang","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1523\/JNEUROSCI.2674-08.2008","article-title":"Systemic Inflammation Alters the Kinetics of Cerebrovascular Tight Junction Disruption After Experimental Stroke in Mice","volume":"28","author":"McColl","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12974-018-1167-8","article-title":"Unique and Shared Inflammatory Profiles of Human Brain Endothelia and Pericytes","volume":"15","author":"Smyth","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00394-008-0712-0","article-title":"Polyunsaturated Fatty Acids Support Epithelial Barrier Integrity and Reduce IL-4 Mediated Permeability In Vitro","volume":"47","author":"Willemsen","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2133880","DOI":"10.1080\/21688370.2022.2133880","article-title":"Trans-Compartmental Regulation of Tight Junction Barrier Function","volume":"11","author":"Naser","year":"2023","journal-title":"Tissue Barriers"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.semcdb.2014.09.002","article-title":"Tight Junction, Selective Permeability, and Related Diseases","volume":"36","author":"Krug","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1749-6632.2012.06526.x","article-title":"Myosin Light Chain Kinase: Pulling the Strings of Epithelial Tight Junction Function","volume":"1258","author":"Cunningham","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1152\/ajpgi.00301.2005","article-title":"Roles of ZO-1, Occludin, and Actin in Oxidant-Induced Barrier Disruption","volume":"290","author":"Musch","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.1073\/pnas.0908869107","article-title":"MLCK-Dependent Exchange and Actin Binding Region-Dependent Anchoring of ZO-1 Regulate Tight Junction Barrier Function","volume":"107","author":"Yu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Lukiw, W.J. (2020). Gastrointestinal (GI) Tract Microbiome-Derived Neurotoxins\u2014Potent Neuro-Inflammatory Signals from the GI Tract via the Systemic Circulation into the Brain. Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00022"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Xiao, G., Tang, L., Yuan, F., Zhu, W., Zhang, S., Liu, Z., Geng, Y., Qiu, X., Zhang, Y., and Su, L. (2013). Eicosapentaenoic Acid Enhances Heat Stress-Impaired Intestinal Epithelial Barrier Function in Caco-2 Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073571"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1054\/clnu.2001.0430","article-title":"Effect of Eicosapentaenoic Acid (EPA) on Tight Junction Permeability in Intestinal Monolayer Cells","volume":"20","author":"Usami","year":"2001","journal-title":"Clin. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/SHK.0000000000000417","article-title":"Eicosapentaenoic Acid Enhances Heatstroke-Impaired Intestinal Epithelial Barrier Function in Rats","volume":"44","author":"Xiao","year":"2015","journal-title":"Shock"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1093\/nar\/gkr567","article-title":"Chk2-Dependent HuR Phosphorylation Regulates Occludin MRNA Translation and Epithelial Barrier Function","volume":"39","author":"Yu","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Tian, F., Gao, X., Zhang, L., Wang, X., Wan, X., Jiang, T., Wu, C., Bi, J., and Lei, Q. (2016). Effects of N-3 PUFAs on Intestinal Mucosa Innate Immunity and Intestinal Microbiota in Mice after Hemorrhagic Shock Resuscitation. Nutrients, 8.","DOI":"10.3390\/nu8100609"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.plefa.2010.02.025","article-title":"Phosphatidylserine-Dependent Neuroprotective Signaling Promoted by Docosahexaenoic Acid","volume":"82","author":"Kim","year":"2010","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Xie, Q., Zhang, Y., Zhang, J., Cui, D., Zhou, Q., and Guo, M. (2022). Promotion Effect of the Blend Containing 2\u2032-FL, OPN and DHA on Oligodendrocyte Progenitor Cells Myelination In Vitro. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1054431"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s11064-008-9845-z","article-title":"Docosahexaenoic Acid Significantly Stimulates Immediate Early Response Genes and Neurite Outgrowth","volume":"34","author":"Dagai","year":"2009","journal-title":"Neurochem. Res."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Chen, S., Zhang, H., Pu, H., Wang, G., Li, W., Leak, R.K., Chen, J., Liou, A.K., and Hu, X. (2014). N-3 PUFA Supplementation Benefits Microglial Responses to Myelin Pathology. Sci. Rep., 4.","DOI":"10.1038\/srep07458"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.neuron.2005.04.012","article-title":"Radial Glial Cells: Defined and Major Intermediates between Embryonicstem Cells and CNS Neurons","volume":"46","author":"Barde","year":"2005","journal-title":"Neuron"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10571-017-0510-4","article-title":"BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity","volume":"38","author":"Lietzau","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Miranda, M., Morici, J.F., Zanoni, M.B., and Bekinschtein, P. (2019). Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Front. Cell. Neurosci., 13.","DOI":"10.3389\/fncel.2019.00363"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"M\u00fcller, P., Duderstadt, Y., Lessmann, V., and M\u00fcller, N.G. (2020). Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041136"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yebeh.2009.11.006","article-title":"Qualitative Analysis of Hippocampal Plastic Changes in Rats with Epilepsy Supplemented with Oral Omega-3 Fatty Acids","volume":"17","author":"Cysneiros","year":"2010","journal-title":"Epilepsy Behav."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Kolarow, R., Kuhlmann, C.R.W., Munsch, T., Zehendner, C., Brigadski, T., Luhmann, H.J., and Lessmann, V. (2014). BDNF-Induced Nitric Oxide Signals in Cultured Rat Hippocampal Neurons: Time Course, Mechanism of Generation, and Effect on Neurotrophin Secretion. Front. Cell. Neurosci., 8.","DOI":"10.3389\/fncel.2014.00323"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Sugasini, D., Yalagala, P.C.R., and Subbaiah, P.V. (2020). Plasma BDNF Is a More Reliable Biomarker than Erythrocyte Omega-3 Index for the Omega-3 Fatty Acid Enrichment of Brain. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-67868-9"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1074\/jbc.M115.693499","article-title":"Docosahexaenoic Acid Promotes Axon Outgrowth by Translational Regulation of Tau and Collapsin Response Mediator Protein 2 Expression","volume":"291","author":"Mita","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.expneurol.2004.11.016","article-title":"Increased Neurogenesis and the Ectopic Granule Cells after Intrahippocampal BDNF Infusion in Adult Rats","volume":"192","author":"Scharfman","year":"2005","journal-title":"Exp. Neurol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1111\/febs.14590","article-title":"Deuterium-Reinforced Linoleic Acid Lowers Lipid Peroxidation and Mitigates Cognitive Impairment in the Q140 Knock in Mouse Model of Huntington\u2019s Disease","volume":"285","author":"Hatami","year":"2018","journal-title":"FEBS J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"12733","DOI":"10.1523\/JNEUROSCI.0605-15.2015","article-title":"A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury","volume":"35","author":"Liu","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1471-4159.2009.06335.x","article-title":"Docosahexaenoic Acid Promotes Hippocampal Neuronal Development and Synaptic Function","volume":"111","author":"Cao","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1007\/s12035-023-03401-z","article-title":"Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment","volume":"60","author":"Bourissai","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1038\/s41467-020-19255-1","article-title":"Acute EPA-Induced Learning and Memory Impairment in Mice Is Prevented by DHA","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Xiao, M., Xiang, W., Chen, Y., Peng, N., Du, X., Lu, S., Zuo, Y., Li, B., Hu, Y., and Li, X. (2022). DHA Ameliorates Cognitive Ability, Reduces Amyloid Deposition, and Nerve Fiber Production in Alzheimer\u2019s Disease. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.852433"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1017\/S0007114511004788","article-title":"Effects of N-3 Fatty Acids, EPA v. DHA, on Depressive Symptoms, Quality of Life, Memory and Executive Function in Older Adults with Mild Cognitive Impairment: A 6-Month Randomised Controlled Trial","volume":"107","author":"Sinn","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1039\/C8FO00074C","article-title":"N-3 Polyunsaturated Fatty Acids Prevent d-Galactose-Induced Cognitive Deficits in Prediabetic Rats","volume":"9","author":"Guo","year":"2018","journal-title":"Food Funct."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Javanainen, M., Enkavi, G., Guix\u00e0-Gonzal\u00e9z, R., Kulig, W., Martinez-Seara, H., Levental, I., and Vattulainen, I. (2019). Reduced Level of Docosahexaenoic Acid Shifts GPCR Neuroreceptors to Less Ordered Membrane Regions. PLoS Comput. Biol., 15.","DOI":"10.1371\/journal.pcbi.1007033"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Moreno, C., de la Cruz, A., and Valenzuela, C. (2016). In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K+ Channels; Interaction and New Targets. Front. Physiol., 7.","DOI":"10.3389\/fphys.2016.00578"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Elinder, F., and Liin, S.I. (2017). Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00043"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Ogawa, T., Sawane, K., Ookoshi, K., and Kawashima, R. (2023). Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults. Nutrients, 15.","DOI":"10.3390\/nu15061499"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/1098-2396(200008)37:2<90::AID-SYN2>3.0.CO;2-Z","article-title":"Docosahexaenoic Acid Inhibits Synaptic Transmission and Epileptiform Activity in the Rat Hippocampus","volume":"37","author":"Young","year":"2000","journal-title":"Synapse"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.sbi.2018.03.015","article-title":"How Lipids Contribute to Ion Channel Function, a Fat Perspective on Direct and Indirect Interactions","volume":"51","year":"2018","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1054\/plef.2002.0407","article-title":"Interactions of N-3 Fatty Acids with Ion Channels in Excitable Tissues","volume":"67","author":"Leaf","year":"2002","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Labrousse, V.F., Nadjar, A., Joffre, C., Costes, L., Aubert, A., Gr\u00e9goire, S., Bretillon, L., and Lay\u00e9, S. (2012). Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036861"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Fan, R., Hua, Y., Shen, J., Xiao, R., and Ma, W. (2022). Dietary Fatty Acids Affect Learning and Memory Ability via Regulating Inflammatory Factors in Obese Mice. J. Nutr. Biochem., 103.","DOI":"10.1016\/j.jnutbio.2022.108959"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuropharm.2012.07.019","article-title":"Cognitive Enhancement by Omega-3 Fatty Acids from Child-Hood to Old Age: Findings from Animal and Clinical Studies","volume":"64","author":"Luchtman","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1139\/bcb-2015-0149","article-title":"Eicosapentaenoic Acid and Docosahexaenoic Acid Increase the Degradation of Amyloid-\u03b2 by Affecting Insulin-Degrading Enzyme1","volume":"94","author":"Grimm","year":"2016","journal-title":"Biochem. Cell Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbi.2019.05.033","article-title":"Omega-3 Polyunsaturated Fatty Acids Promote Brain-to-Blood Clearance of \u03b2-Amyloid in a Mouse Model with Alzheimer\u2019s Disease","volume":"85","author":"Yan","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1096\/fj.201600896","article-title":"Omega-3 Polyunsaturated Fatty Acids Promote Amyloid-b Clearance from the Brain through Mediating the Function of the Glymphatic System","volume":"31","author":"Ren","year":"2017","journal-title":"FASEB J."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neuint.2011.06.012","article-title":"The Influence and the Mechanism of Docosahexaenoic Acid on a Mouse Model of Parkinson\u2019s Disease","volume":"59","author":"Ozsoy","year":"2011","journal-title":"Neurochem. Int."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.brainres.2009.05.018","article-title":"Exercise Contributes to the Effects of DHA Dietary Supplementation by Acting on Membrane-Related Synaptic Systems","volume":"1341","author":"Chytrova","year":"2010","journal-title":"Brain Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1089\/neu.2011.1872","article-title":"The Salutary Effects of DHA Dietary Supplementation on Cognition, Neuroplasticity, and Membrane Homeostasis after Brain Trauma","volume":"28","author":"Wu","year":"2011","journal-title":"J. Neurotrauma"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuint.2016.10.012","article-title":"The Protective Mechanism of Docosahexaenoic Acid in Mouse Model of Parkinson: The Role of Heme Oxygenase","volume":"101","author":"Ozkan","year":"2016","journal-title":"Neurochem. Int."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1196\/annals.1410.050","article-title":"Endocrine Factors in Stress and Psychiatric Disorders: Focus on Anxiety and Salivary Steroids","volume":"1148","author":"Jezova","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nrendo.2009.106","article-title":"Stress and Disorders of the Stress System","volume":"5","author":"Chrousos","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1262-3636(07)70039-3","article-title":"Fish Oil Prevents the Adrenal Activation Elicited by Mental Stress in Healthy Men","volume":"29","author":"Delarue","year":"2003","journal-title":"Diabetes Metab."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1523\/JNEUROSCI.3569-08.2009","article-title":"Increased Phospholipase A2 Activity and Inflammatory Response but Decreased Nerve Growth Factor Expression in the Olfactory Bulbectomized Rat Model of Depression: Effects of Chronic Ethyl-Eicosapentaenoate Treatment","volume":"29","author":"Song","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.psyneuen.2008.06.012","article-title":"Decreased Brain Docosahexaenoic Acid Content Produces Neurobiological Effects Associated with Depression: Interactions with Reproductive Status in Female Rats","volume":"33","author":"Levant","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s12035-016-9809-2","article-title":"Lifelong Nutritional Omega-3 Deficiency Evokes Depressive-Like State Through Soluble Beta Amyloid","volume":"54","author":"Morgese","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.psyneuen.2013.01.013","article-title":"Relationship between the Hypothalamic-Pituitary-Adrenal-Axis and Fatty Acid Metabolism in Recurrent Depression","volume":"38","author":"Mocking","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1365-2826.2008.01711.x","article-title":"The Neuroendocrinology of Stress: A Never Ending Story","volume":"20","author":"Lightman","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0006-8993(02)04113-6","article-title":"Possible Regulatory Mechanism of DHA-Induced Anti-Stress Reaction in Rats","volume":"964","author":"Takeuchi","year":"2003","journal-title":"Brain Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.plefa.2006.07.012","article-title":"Relationship between Omega-3 Fatty Acids and Plasma Neuroactive Steroids in Alcoholism, Depression and Controls","volume":"75","author":"Nieminen","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1172\/JCI118507","article-title":"Effect of Docosahexaenoic Acid on Aggression Rapid Publication The Effect of Docosahexaenoic Acid on Aggression in Young Adults A Placebo-Controlled Double-Blind Study","volume":"97","author":"Hamazaki","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Oravcova, H., Katrencikova, B., Garaiova, I., Durackova, Z., Trebaticka, J., and Jezova, D. (2022). Stress Hormones Cortisol and Aldosterone, and Selected Markers of Oxidative Stress in Response to Long-Term Supplementation with Omega-3 Fatty Acids in Adolescent Children with Depression. Antioxidants, 11.","DOI":"10.3390\/antiox11081546"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.psyneuen.2018.07.002","article-title":"Omega-3 Polyunsaturated Fatty Acid Levels and Dysregulations in Biological Stress Systems","volume":"97","author":"Thesing","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.psychres.2009.04.013","article-title":"Effects of Eicosapentaenoic Acid and Fluoxetine on Plasma Cortisol, Serum Interleukin-1beta and Interleukin-6 Concentrations in Patients with Major Depressive Disorder","volume":"178","author":"Jazayeri","year":"2010","journal-title":"Psychiatry Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/sj.mp.4001462","article-title":"Ethyl-Eicosapentaenoic Acid Ingestion Prevents Corticosterone-Mediated Memory Impairment Induced by Central Administration of Interleukin-1\u03b2 in Rats","volume":"9","author":"Song","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1038\/s41380-021-01077-2","article-title":"Omega-3 Supplementation and Stress Reactivity of Cellular Aging Biomarkers: An Ancillary Substudy of a Randomized, Controlled Trial in Midlife Adults","volume":"26","author":"Madison","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"112911","DOI":"10.1016\/j.psychres.2020.112911","article-title":"Omega-3 Fatty-Acids Modulate Symptoms of Depressive Disorder, Serum Levels of Omega-3 Fatty Acids and Omega-6\/Omega-3 Ratio in Children. A Randomized, Double-Blind and Controlled Trial","volume":"287","author":"Gushina","year":"2020","journal-title":"Psychiatry Res."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Katren\u010d\u00edkov\u00e1, B., Vav\u00e1kov\u00e1, M., Paduchov\u00e1, Z., Nagyov\u00e1, Z., Garaiova, I., Muchov\u00e1, J., \u010eura\u010dkov\u00e1, Z., and Trebatick\u00e1, J. (2021). Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial. Antioxidants, 10.","DOI":"10.3390\/antiox10081256"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"E53","DOI":"10.1210\/jc.2013-2673","article-title":"Adipose Inflammation in Obesity: Relationship with Circulating Levels of Inflammatory Markers and Association with Surgery-Induced Weight Loss","volume":"99","author":"Lasselin","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1176\/appi.ajp.2015.15020152","article-title":"Inflammation: Depression Fans the Flames and Feasts on the Heat","volume":"172","author":"Derry","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"ref_169","first-page":"980","article-title":"Role of C-Reactive Protein in Periodontal Disease\u2014A Review","volume":"4","author":"Gupta","year":"2017","journal-title":"Int. J. Contemp. Med. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.psyneuen.2015.08.014","article-title":"Hypothalamic-Pituitary-Adrenal Axis Dysregulation and Cortisol Activity in Obesity: A Systematic Review","volume":"62","author":"Epel","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archgenpsychiatry.2009.50","article-title":"Major Depressive Disorder and Hypothalamic-Pituitary-Adrenal Axis Activity Results from a Large Cohort Study","volume":"66","author":"Vreeburg","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/0884533609335376","article-title":"Fish Oil Supplementation Lowers C-Reactive Protein Levels Independent of Triglyceride Reduction in Patients with End-Stage Renal Disease","volume":"24","author":"Bowden","year":"2009","journal-title":"Nutr. Clin. Pract."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1177\/147323000903700619","article-title":"Effects of N-3 Polyunsaturated Fatty Acid Therapy on Plasma Inflammatory Markers and N-Terminal Pro-Brain Natriuretic Peptide in Elderly Patients with Chronic Heart Failure","volume":"37","author":"Zhao","year":"2009","journal-title":"J. Int. Med. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.nutres.2012.03.003","article-title":"Omega-3 Fatty Acids Administered in Phosphatidylserine Improved Certain Aspects of High Chronic Stress in Men","volume":"32","author":"Hellhammer","year":"2012","journal-title":"Nutr. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2006.08.009","article-title":"Cytokine-Effects on Glucocorticoid Receptor Function: Relevance to Glucocorticoid Resistance and the Pathophysiology and Treatment of Major Depression","volume":"21","author":"Pace","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"347965","DOI":"10.1155\/2015\/347965","article-title":"Sustained Interleukin-1\u03b2 Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids","volume":"2015","author":"Escoll","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1039\/C8FO01404C","article-title":"DHA-Phospholipids (DHA-PL) and EPA-Phospholipids (EPA-PL) Prevent Intestinal Dysfunction Induced by Chronic Stress","volume":"10","author":"Cao","year":"2019","journal-title":"Food Funct."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1079\/BJN2002634","article-title":"Improvement of the Probiotic Effect of Micro-Organisms by Their Combination with Maltodextrins, Fructo-Oligosaccharides and Polyunsaturated Fatty Acids","volume":"88","author":"Bomba","year":"2002","journal-title":"Br. J. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Kaliannan, K., Wang, B., Li, X.-Y., Kim, K.-J., and Kang, J.X. (2015). A Host-Microbiome Interaction Mediates the Opposing Effects of Omega-6 and Omega-3 Fatty Acids on Metabolic Endotoxemia. Sci. Rep., 5.","DOI":"10.1038\/srep11276"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1021\/acs.jafc.9b05899","article-title":"Dietary Supplementation of N-3 LCPUFAs Prevents Salmonellosis in a Murine Model","volume":"68","author":"Liu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12944-016-0245-0","article-title":"Effects of Sardine-Enriched Diet on Metabolic Control, Inflammation and Gut Microbiota in Drug-Na\u00efve Patients with Type 2 Diabetes: A Pilot Randomized Trial","volume":"15","author":"Canivell","year":"2016","journal-title":"Lipids Health Dis."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"102182","DOI":"10.1016\/j.plefa.2020.102182","article-title":"Effect of Dietary N-3 Polyunsaturated Fatty Acids on the Composition of Cecal Microbiome of Lohmann Hens","volume":"162","author":"Neijat","year":"2020","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Menni, C., Zierer, J., Pallister, T., Jackson, M.A., Long, T., Mohney, R.P., Steves, C.J., Spector, T.D., and Valdes, A.M. (2017). Omega-3 Fatty Acids Correlate with Gut Microbiome Diversity and Production of N-Carbamylglutamate in Middle Aged and Elderly Women. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-10382-2"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1863133","DOI":"10.1080\/19490976.2020.1863133","article-title":"The Prebiotic Effects of Omega-3 Fatty Acid Supplementation: A Six-Week Randomised Intervention Trial","volume":"13","author":"Vijay","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_185","first-page":"892","article-title":"N-3 Polyunsaturated Fatty Acids and Gut Microbiota","volume":"26","author":"Jayapala","year":"2022","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Tao, F., Xing, X., Wu, J., and Jiang, R. (2021). Enteral Nutrition Modulation with N-3 PUFAs Directs Microbiome and Lipid Metabolism in Mice. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0248482"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1017\/S0007114517002999","article-title":"Deficiency of Essential Dietary N-3 PUFA Disrupts the Caecal Microbiome and Metabolome in Mice","volume":"118","author":"Robertson","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.plefa.2013.03.006","article-title":"Comparative Effects of Well-Balanced Diets Enriched in \u03b1-Linolenic or Linoleic Acids on LC-PUFA Metabolism in Rat Tissues","volume":"88","author":"Blanchard","year":"2013","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbi.2016.07.145","article-title":"Omega-3 Polyunsaturated Fatty Acids Critically Regulate Behaviour and Gut Microbiota Development in Adolescence and Adulthood","volume":"59","author":"Robertson","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1743-7075-8-44","article-title":"Involvement of Gut Microbial Fermentation in the Metabolic Alterations Occurring in N-3 Polyunsaturated Fatty Acids-Depleted Mice","volume":"8","author":"Pachikian","year":"2011","journal-title":"Nutr. Metab."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Horiuchi, H., Kamikado, K., Aoki, R., Suganuma, N., Nishijima, T., Nakatani, A., and Kimura, I. (2020). Bifidobacterium Animalis Subsp. Lactis GCL2505 Modulates Host Energy Metabolism via the Short-Chain Fatty Acid Receptor GPR43. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-60984-6"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Patterson, E., Wall, R., Lisai, S., Ross, R.P., Dinan, T.G., Cryan, J.F., Fitzgerald, G.F., Banni, S., Quigley, E.M., and Shanahan, F. (2017). Bifidobacterium Breve with \u03b1-Linolenic Acid Alters the Composition, Distribution and Transcription Factor Activity Associated with Metabolism and Absorption of Fat. Sci. Rep., 7.","DOI":"10.1038\/srep43300"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Lu, J., Shataer, D., Yan, H., Dong, X., Zhang, M., Qin, Y., Cui, J., and Wang, L. (2024). Probiotics and Non-Alcoholic Fatty Liver Disease: Unveiling the Mechanisms of Lactobacillus Plantarum and Bifidobacterium Bifidum in Modulating Lipid Metabolism, Inflammation, and Intestinal Barrier Integrity. Foods, 13.","DOI":"10.3390\/foods13182992"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.plefa.2015.03.002","article-title":"Docosahexaenoic Acid Differentially Affects TNF\u03b1 and IL-6 Expression in LPS-Stimulated RAW 264.7 Murine Macrophages","volume":"97","author":"Honda","year":"2015","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1476-511X-9-12","article-title":"Docosahexaenoic Acid Prevents Dendritic Cell Maturation and In Vitro and In Vivo Expression of the IL-12 Cytokine Family","volume":"9","author":"Kong","year":"2010","journal-title":"Lipids Health Dis."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/07315724.2004.10719345","article-title":"Eicosapentaenoic Acid Prevents LPS-Induced TNF-\u03b1 Expression by Preventing NF-\u039aB Activation","volume":"23","author":"Zhao","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Vanden Berghe, W., Vermeulen, L., Delerive, P., De Bosscher, K., Staels, B., and Haegeman, G. (2003). A Paradigm for Gene Regulation: Inflammation, NF-KB and PPAR. Peroxisomal Disorders and Regulation of Genes, Springer.","DOI":"10.1007\/978-1-4419-9072-3_22"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1152\/ajplung.00077.2002","article-title":"NF-B Inhibition by-3 Fatty Acids Modulates LPS-Stimulated Macrophage TNF-Transcription","volume":"284","author":"Novak","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"28418","DOI":"10.1074\/jbc.M203343200","article-title":"LAT Displacement from Lipid Rafts as a Molecular Mechanism for the Inhibition of T Cell Signaling by Polyunsaturated Fatty Acids","volume":"277","author":"Zeyda","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/S0007114512000542","article-title":"Reversal of Severe Methotrexate-Induced Intestinal Damage Using Enteral n-3 Fatty Acids","volume":"109","author":"Koppelmann","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1526S","DOI":"10.1093\/ajcn\/83.6.1526S","article-title":"N\u22123 Fatty Acid Dietary Recommendations and Food Sources to Achieve Essentiality and Cardiovascular Benefits","volume":"83","author":"Gebauer","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4162\/nrp.2021.15.2.137","article-title":"Role of N-3 Long-Chain Polyunsaturated Fatty Acids in Human Nutrition and Health: Review of Recent Studies and Recommendations","volume":"15","year":"2021","journal-title":"Nutr. Res. Pract."},{"key":"ref_203","unstructured":"Schneider, E., Balasubramanian, R., Ferri, A., Cotter, P.D., Clarke, G., and Cryan, J.F. Fibre & fermented foods: Differential effects on the microbiota-gut-brain axis, Proc Nutr Soc."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"104465","DOI":"10.1016\/j.tifs.2024.104465","article-title":"Impact of Air Frying on Food Lipids: Oxidative Evidence, Current Research, and Insights into Domestic Mitigation by Natural Antioxidants","volume":"147","author":"Viana","year":"2024","journal-title":"Trends Food Sci. Technol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/1\/71\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:05Z","timestamp":1760115305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/1\/71"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":204,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["molecules30010071"],"URL":"https:\/\/doi.org\/10.3390\/molecules30010071","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]}}}