{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:31:10Z","timestamp":1771486270904,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T00:00:00Z","timestamp":1735430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["IN209222"],"award-info":[{"award-number":["IN209222"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["SIP 20240385"],"award-info":[{"award-number":["SIP 20240385"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["SIP 20240516"],"award-info":[{"award-number":["SIP 20240516"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["SIP 20240389"],"award-info":[{"award-number":["SIP 20240389"]}]},{"name":"Secretaria de Investigaci\u00f3n y Posgrado (SIP) from the Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, M\u00e9xico","award":["IN209222"],"award-info":[{"award-number":["IN209222"]}]},{"name":"Secretaria de Investigaci\u00f3n y Posgrado (SIP) from the Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, M\u00e9xico","award":["SIP 20240385"],"award-info":[{"award-number":["SIP 20240385"]}]},{"name":"Secretaria de Investigaci\u00f3n y Posgrado (SIP) from the Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, M\u00e9xico","award":["SIP 20240516"],"award-info":[{"award-number":["SIP 20240516"]}]},{"name":"Secretaria de Investigaci\u00f3n y Posgrado (SIP) from the Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, M\u00e9xico","award":["SIP 20240389"],"award-info":[{"award-number":["SIP 20240389"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Traumatic spinal cord injury (SCI) is a serious medical condition that places patients at high risk of developing gastric ulceration and gastrointestinal bleeding. One preventative strategy involves the use of omeprazole; however, its chronic use is associated with adverse effects, highlighting the need for alternative therapies. This study evaluated the protective effects of methyl eugenol (ME) on gastric mucosal damage in a rat model of SCI. ME was administered orally at doses of 30, 100, and 177 mg\/kg in SCI induced at the T9 level, alongside diclofenac or ketorolac (30 mg\/kg each). The enzymatic activity of superoxide dismutase, catalase, and glutathione peroxidase was assessed, and the levels of total glutathione and malondialdehyde were determined using biochemical kits. Additionally, stomach histological sections were analyzed. ME exhibited dose-dependent gastroprotective effects, with maximal protection observed at 177 mg\/kg in the presence of diclofenac (9.78 \u00b1 2.16 mm2) or ketorolac (12.49 \u00b1 2.17 mm2). A histological analysis confirmed these findings. In conclusion, methyl eugenol protects the gastric mucosa from SCI-induced damage, with glutathione peroxidase and catalase playing key roles in its mechanism of gastroprotection.<\/jats:p>","DOI":"10.3390\/molecules30010086","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T14:35:42Z","timestamp":1735742142000},"page":"86","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-9711","authenticated-orcid":false,"given":"Leticia","family":"Cruz-Antonio","sequence":"first","affiliation":[{"name":"Facultad de Estudios Superiores Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Av. Guelatao No. 66, Colonia Ej\u00e9rcito de Oriente, Iztapalapa, Ciudad de M\u00e9xico 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-6757","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"S\u00e1nchez-Mendoza","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda de Plantas Medicinales Mexicanas, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Casco de Santo Tom\u00e1s, Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3630-5979","authenticated-orcid":false,"given":"Jazm\u00edn","family":"Garc\u00eda-Machorro","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de la Conservaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Casco de Santo Tom\u00e1s, Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaraset","family":"L\u00f3pez-Lorenzo","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda de Plantas Medicinales Mexicanas, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Casco de Santo Tom\u00e1s, Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-744X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda de Plantas Medicinales Mexicanas, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Casco de Santo Tom\u00e1s, Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"van der Vlegel, M., Haagsma, J.A., Havermans, R.J.M., de Munter, L., de Jongh, M.A.C., and Polinder, S. 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