{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:15:34Z","timestamp":1780575334098,"version":"3.54.1"},"reference-count":59,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation Interdisciplinary Synergy Programme 2022","doi-asserted-by":"publisher","award":["NNF22OC0077099"],"award-info":[{"award-number":["NNF22OC0077099"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The overexpression of the epidermal growth factor receptor (EGFR) in certain types of prostate cancers and glioblastoma makes it a promising target for targeted radioligand therapy. In this context, pairing an EGFR-targeting peptide with the emerging theranostic pair comprising the Auger electron emitter cobalt-58m (58mCo) and the Positron Emission Tomography-isotope cobalt-55 (55Co) would be of great interest for creating novel radiopharmaceuticals for prostate cancer and glioblastoma theranostics. In this study, GE11 (YHWYGYTPQNVI) was investigated for its EGFR-targeting potential when conjugated using click chemistry to N1-((triazol-4-yl)methyl)-N1,N2,N2-tris(pyridin-2-ylmethyl)ethane-1,2-diamine (TZTPEN). This chelator is suitable for binding Co2+ and Co3+. With cobalt-57 (57Co) serving as a surrogate radionuclide for 55\/58mCo, the novel GE11-TZTPEN construct was successfully radiolabeled with a high radiochemical yield (99%) and purity (&gt;99%). [57Co]Co-TZTPEN-GE11 showed high stability in PBS (pH 5) and specific uptake in EGFR-positive cell lines. Disappointingly, no tumor uptake was observed in EGFR-positive tumor-bearing mice, with most activity being accumulated predominantly in the liver, gall bladder, kidneys, and spleen. Some bone uptake was also observed, suggesting in vivo dissociation of 57Co from the complex. In conclusion, [57Co]Co-TZTPEN-GE11 shows poor pharmacokinetics in a mouse model and is, therefore, not deemed suitable as a targeting radiopharmaceutical for EGFR.<\/jats:p>","DOI":"10.3390\/molecules30020212","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T05:06:34Z","timestamp":1736226394000},"page":"212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics"],"prefix":"10.3390","volume":"30","author":[{"given":"Lorraine Gaenaelle","family":"G\u00e9","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Odense University Hospital, Kloevervaenget 47, 5000 Odense C, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias Bogetoft","family":"Danielsen","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-2857","authenticated-orcid":false,"given":"Aaraby Yoheswaran","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Odense University Hospital, Kloevervaenget 47, 5000 Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-1692","authenticated-orcid":false,"given":"Mathias Lander","family":"Skavenborg","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8729-937X","authenticated-orcid":false,"given":"Niels","family":"Langkj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Odense University Hospital, Kloevervaenget 47, 5000 Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9492-448X","authenticated-orcid":false,"given":"Helge","family":"Thisgaard","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Odense University Hospital, Kloevervaenget 47, 5000 Odense C, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5587-0626","authenticated-orcid":false,"given":"Christine J.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2967\/jnumed.119.233015","article-title":"Improving Contrast and Detectability: Imaging with [55Co]Co-DOTATATE in Comparison with [64Cu]Cu-DOTATATE and [68Ga]Ga-DOTATATE","volume":"61","author":"Andersen","year":"2020","journal-title":"J. Nucl. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Baun, C., Dam, J.H., Hildebrandt, M.G., Ewald, J.D., Kristensen, B.W., Gammelsr\u00f8d, V.S., Olsen, B.B., and Thisgaard, H. (2023). Preclinical evaluation of [58mCo]Co-DOTA-PSMA-617 for Auger electron therapy of prostate cancer. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-43429-8"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Baun, C., Mitran, B., Rinne, S.S., Dam, J.H., Olsen, B.B., Tolmachev, V., Orlova, A., and Thisgaard, H. (2020). Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer. Molecules, 25.","DOI":"10.3390\/molecules25245993"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s11307-015-0911-z","article-title":"In Vivo Evaluation of a Bombesin Analogue Labeled with Ga-68 and Co-55\/57","volume":"18","author":"Dam","year":"2016","journal-title":"Mol. Imaging Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s11307-017-1121-7","article-title":"A PSMA Ligand Labeled with Cobalt-55 for PET Imaging of Prostate Cancer","volume":"19","author":"Dam","year":"2017","journal-title":"Mol. Imaging Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0969-8051(99)00077-3","article-title":"55Co-EDTA for renal imaging using positron emission tomography (PET): A feasibility study","volume":"27","author":"Goethals","year":"2000","journal-title":"Nucl. Med. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Houson, H.A., Tekin, V., Lin, W., Aluicio-Sarduy, E., Engle, J.W., and Lapi, S.E. (2022). PET Imaging of the Neurotensin Targeting Peptide NOTA-NT-20.3 Using Cobalt-55, Copper-64 and Gallium-68. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14122724"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"526","DOI":"10.2310\/7290.2015.00025","article-title":"Cyclotron Production of High-Specific Activity 55Co and In Vivo Evaluation of the Stability of 55Co Metal-Chelate-Peptide Complexes","volume":"14","author":"Mastren","year":"2015","journal-title":"Mol. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Radford, L.L., Fernandez, S., Beacham, R., El Sayed, R., Farkas, R., Bene\u0161ov\u00e1, M., M\u00fcller, C., and Lapi, S.E. (2019). New 55Co-labeled Albumin-Binding Folate Derivatives as Potential PET Agents for Folate Receptor Imaging. Pharmaceuticals, 12.","DOI":"10.3390\/ph12040166"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/jlcr.1919","article-title":"Radiosynthesis of 55Co- and 58mCo-labelled DOTATOC for positron emission tomography imaging and targeted radionuclide therapy","volume":"54","author":"Thisgaard","year":"2011","journal-title":"J. Label. Compd. Radiopharm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2967\/jnumed.114.137182","article-title":"Evaluation of cobalt-labeled octreotide analogs for molecular imaging and auger electron-based radionuclide therapy","volume":"55","author":"Thisgaard","year":"2014","journal-title":"J. Nucl. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1118\/1.2229428","article-title":"Dosimetric characterization of radionuclides for systemic tumor therapy: Influence of particle range, photon emission, and subcellular distribution","volume":"33","author":"Bernhardt","year":"2006","journal-title":"Med. Phys."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hlca.19770600115","article-title":"Pyridinderivate als Komplexbildner. XI. Die Thermodynamik der Metallkomplexbildung mit Bis-, Tris- und Tetrakis[(2-pyridyl)methyl]-aminen","volume":"60","author":"Anderegg","year":"1977","journal-title":"Helv. Chim. Acta"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/hlca.19510340534","article-title":"Komplexone XX. Stabilit\u00e4tskonstanten von Schwermetallkomplexen der \u00c4thylendiamin-tetraessigs\u00e4ure","volume":"34","author":"Schwarzenbach","year":"1951","journal-title":"Helv. Chim. Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","article-title":"The somatic genomic landscape of glioblastoma","volume":"155","author":"Brennan","year":"2013","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1158\/0008-5472.CAN-16-1656","article-title":"HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone","volume":"77","author":"Day","year":"2017","journal-title":"Cancer Res."},{"key":"ref_17","first-page":"3438","article-title":"Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer1","volume":"8","author":"Tortora","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/313144a0","article-title":"Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin","volume":"313","author":"Libermann","year":"1985","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1742-4658.2009.07448.x","article-title":"Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer","volume":"277","author":"Mitsudomi","year":"2010","journal-title":"FEBS J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1038\/s41416-020-01052-8","article-title":"EGFR as a stable marker of prostate cancer dissemination to bones","volume":"123","author":"Stoupiec","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ijc.2910560114","article-title":"Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma","volume":"56","author":"Schlegel","year":"1994","journal-title":"Int. J. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.1158\/1078-0432.CCR-07-1257","article-title":"Clinical Significance of Epidermal Growth Factor Receptor Protein Overexpression and Gene Copy Number Gains in Prostate Cancer","volume":"13","author":"Schlomm","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1096\/fj.05-4058com","article-title":"Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1021\/jm201544y","article-title":"Phthalocyanine\u2013Peptide Conjugates for Epidermal Growth Factor Receptor Targeting","volume":"55","author":"Ongarora","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1021\/nl300395q","article-title":"Tuning Nanoparticle Uptake: Live-Cell Imaging Reveals Two Distinct Endocytosis Mechanisms Mediated by Natural and Artificial EGFR Targeting Ligand","volume":"12","author":"Mickler","year":"2012","journal-title":"Nano Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/iub.1002","article-title":"PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors","volume":"64","author":"Abourbeh","year":"2012","journal-title":"IUBMB Life"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1158\/1535-7163.MCT-12-0211","article-title":"An optical probe for noninvasive molecular imaging of orthotopic brain tumors overexpressing epidermal growth factor receptor","volume":"11","author":"Agnes","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nucmedbio.2018.11.003","article-title":"68Ga-labelled NOTA-RGD-GE11 peptide for dual integrin and EGFR-targeted tumour imaging","volume":"68\u201369","author":"Chen","year":"2019","journal-title":"Nucl. Med. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2147\/IJN.S53310","article-title":"GE11-modified liposomes for non-small cell lung cancer targeting: Preparation, ex vitro and in vivo evaluation","volume":"9","author":"Cheng","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.nucmedbio.2020.10.004","article-title":"Synthesis and evaluation of [18F]FP-Lys-GE11 as a new radiolabeled peptide probe for epidermal growth factor receptor (EGFR) imaging","volume":"90\u201391","author":"Li","year":"2020","journal-title":"Nucl. Med. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40199-017-0179-8","article-title":"99mTc-radiolabeled GE11-modified peptide for ovarian tumor targeting","volume":"25","author":"Rahmanian","year":"2017","journal-title":"DARU J. Pharma. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpharm.2008.07.012","article-title":"Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo","volume":"363","author":"Song","year":"2008","journal-title":"Int. J. Pharmaceut."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1038\/mtna.2013.58","article-title":"EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene","volume":"2","author":"Vetter","year":"2013","journal-title":"Mol. Ther. Nucleic. Acids"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"27690","DOI":"10.1021\/acsomega.2c03407","article-title":"Toward the Development of GE11-Based Radioligands for Imaging of Epidermal Growth Factor Receptor-Positive Tumors","volume":"7","author":"Judmann","year":"2022","journal-title":"ACS Omega"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Judmann, B., W\u00e4ngler, B., Schirrmacher, R., Fricker, G., and W\u00e4ngler, C. (2023). Towards Radiolabeled EGFR-Specific Peptides: Alternatives to GE11. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020273"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s00726-018-2616-5","article-title":"Exploring pitfalls of 64Cu-labeled EGFR-targeting peptide GE11 as a potential PET tracer","volume":"50","author":"Striese","year":"2018","journal-title":"Amino Acids"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0969-8051(94)00081-T","article-title":"Effect of \u201cco-ligand\u201d on the biodistribution of 99mTc-labeled hydrazino nicotinic acid derivatized chemotactic peptides","volume":"22","author":"Babich","year":"1995","journal-title":"Nucl. Med. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/bc0603788","article-title":"In vitro and in vivo evaluation of 64Cu-labeled DOTA-linker-bombesin(7\u201314) analogues containing different amino acid linker moieties","volume":"18","author":"Parry","year":"2007","journal-title":"Bioconjug. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1021\/bc700453h","article-title":"An 86Y-Labeled Mirror-Image Oligonucleotide: Influence of Y-DOTA Isomers on the Biodistribution in Rats","volume":"19","author":"Schlesinger","year":"2008","journal-title":"Bioconj. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1021\/ic101775q","article-title":"Isomerism of [64Cu-NOTA-Bn]-Labeled Radiotracers: Separation of Two Complex Isomers and Determination of Their Interconversion Energy Barrier Using Ion Pair Chromatography","volume":"50","author":"Schlesinger","year":"2011","journal-title":"Inorg. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1021\/bc800262m","article-title":"Influence of the Molecular Charge on the Biodistribution of Bombesin Analogues Labeled with the [99mTc(CO)3]-Core","volume":"19","author":"Schweinsberg","year":"2008","journal-title":"Bioconj. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lee, I., Kim, M.H., Lee, K., Oh, K., Lim, H., Ahn, J.H., Lee, Y.J., Cheon, G.J., Chi, D.Y., and Lim, S.M. (2023). Comparison of the Effects of DOTA and NOTA Chelators on 64Cu-Cudotadipep and 64Cu-Cunotadipep for Prostate Cancer. Diagnostics, 13.","DOI":"10.3390\/diagnostics13162649"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Mitran, B., Thisgaard, H., Rinne, S., Dam, J., Azami, F., Tolmachev, V., Orlova, A., and Rosenstr\u00f6m, U. (2019). Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-52914-y"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Rinne, S.S., Dahlsson Leitao, C., Saleh-Nihad, Z., Mitran, B., Tolmachev, V., St\u00e5hl, S., L\u00f6fblom, J., and Orlova, A. (2020). Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21061972"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jconrel.2022.07.018","article-title":"Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment","volume":"349","author":"Hailing","year":"2022","journal-title":"J. Control Release"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1039\/D0SM00428F","article-title":"Amphiphilic drug\u2013peptide\u2013polymer conjugates based on poly(ethylene glycol) and hyperbranched polyglycerol for epidermal growth factor receptor targeting: The effect of conjugate aggregation on in vitro activity","volume":"16","author":"Kasza","year":"2020","journal-title":"Soft Matter"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1016\/j.tetlet.2012.05.039","article-title":"Enzymatic C-terminal amidation of amino acids and peptides","volume":"53","author":"Nuijens","year":"2012","journal-title":"Tetrahed. Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1021\/ja805174z","article-title":"Multifunctional prenylated peptides for live cell analysis","volume":"131","author":"Wollack","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.aihch.2020.10.001","article-title":"Chapter Three\u2014Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic?","volume":"Volume 134","author":"Meanwell","year":"2021","journal-title":"Advances in Heterocyclic Chemistry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.1039\/C8OB01617H","article-title":"Stepwise triple-click functionalization of synthetic peptides","volume":"16","author":"Pohl","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1016\/S0040-4039(00)99113-5","article-title":"Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking of protecting groups in peptide synthesis","volume":"30","author":"Pearson","year":"1989","journal-title":"Tetrahed. Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1039\/c4ce00736k","article-title":"Electroactive tetrathiafulvalene based pyridine-mono and -bis(1,2,3-triazoles) click ligands: Synthesis, crystal structures and coordination chemistry","volume":"16","author":"Biet","year":"2014","journal-title":"CrystEngComm"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"12232","DOI":"10.1039\/C8RA00283E","article-title":"Computational investigations of click-derived 1,2,3-triazoles as keystone ligands for complexation with transition metals: A review","volume":"8","author":"Hosseinnejad","year":"2018","journal-title":"RSC Adv."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0020-1693(00)89283-X","article-title":"Crystal structure determination and strain analysis of cobalt(III) and copper(II)complexes of hexadentate and tetradentate ligands containing pyridyl arms","volume":"155","author":"Mandel","year":"1989","journal-title":"Inorg. Chim. Acta."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"114731","DOI":"10.1016\/j.poly.2020.114731","article-title":"Influence of the flexible tetrapyridines on electrocatalytic water oxidation by cobalt complexes","volume":"189","author":"Xie","year":"2020","journal-title":"Polyhedron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1021\/acs.bioconjchem.4c00043","article-title":"Radiolabeling Diaminosarcophagine with Cyclotron-Produced Cobalt-55 and [55Co]Co-NT-Sarcage as a Proof of Concept in a Murine Xenograft Model","volume":"35","author":"Lin","year":"2024","journal-title":"Bioconj. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e202412357","DOI":"10.1002\/anie.202412357","article-title":"Controlling the Redox Chemistry of Cobalt Radiopharmaceuticals","volume":"63","author":"Lin","year":"2024","journal-title":"Angew. Chem. In. Ed."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"10698","DOI":"10.1039\/c1dt10594a","article-title":"Switching on oxygen activation by cobalt complexes of pentadentate ligands","volume":"40","author":"Vad","year":"2011","journal-title":"Dalton Trans."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1021\/ic301834x","article-title":"Iron Coordination Chemistry with New Ligands Containing Triazole and Pyridine Moieties. Comparison of the Coordination Ability of the N-Donors","volume":"52","author":"Rebilly","year":"2013","journal-title":"Inorg. Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/2\/212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:24:15Z","timestamp":1759919055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/2\/212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":59,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["molecules30020212"],"URL":"https:\/\/doi.org\/10.3390\/molecules30020212","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}