{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T10:50:54Z","timestamp":1789296654086,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo\u2014FAPESP","award":["13\/07600-3"],"award-info":[{"award-number":["13\/07600-3"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo\u2014FAPESP","award":["23\/08418-6"],"award-info":[{"award-number":["23\/08418-6"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo\u2014FAPESP","award":["23\/12447-1"],"award-info":[{"award-number":["23\/12447-1"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo\u2014FAPESP","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq (Brazil)","award":["13\/07600-3"],"award-info":[{"award-number":["13\/07600-3"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq (Brazil)","award":["23\/08418-6"],"award-info":[{"award-number":["23\/08418-6"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq (Brazil)","award":["23\/12447-1"],"award-info":[{"award-number":["23\/12447-1"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq (Brazil)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014CAPES","award":["13\/07600-3"],"award-info":[{"award-number":["13\/07600-3"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014CAPES","award":["23\/08418-6"],"award-info":[{"award-number":["23\/08418-6"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014CAPES","award":["23\/12447-1"],"award-info":[{"award-number":["23\/12447-1"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014CAPES","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the present study, the hexane extract from branches of Drimys brasiliensis (Winteraceae) displayed potent activity against Schistosoma mansoni parasites (100% mortality of the worms at 200 \u03bcg\/mL). Bioactivity-guided fractionation afforded, in addition to the previously reported bioactive sesquiterpene 3,6-epidioxy-bisabola-1,10-diene, two chemically related drimane sesquiterpenes\u2014polygodial (1) and 9-deoxymuzigadial (2). The anti-S. mansoni effects for compounds 1 and 2 were determined in vitro, with compound 1 demonstrating significant potency (EC50 value of 10 \u03bcM for both male and female worms), while 2 was inactive. Cytotoxicity assays against Vero cells revealed no toxicity for either compound (CC50 &gt; 200 \u03bcM). Additionally, an in silico analysis was conducted using the SwissADME platform for 1, revealing that this natural sesquiterpene exhibited adherence to several ADME parameters and no PAINS violations. Finally, in vivo studies with S. mansoni-infected mice treated with compound 1 demonstrated a 44.0% reduction in worm burden, accompanied by decreases in egg production of 71.8% in feces and 69.5% in intestines. These findings highlight the potential of polygodial (1) as a promising prototype for schistosomiasis treatment.<\/jats:p>","DOI":"10.3390\/molecules30020267","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T05:40:40Z","timestamp":1736746840000},"page":"267","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In Vitro and In Vivo Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from Drimys brasiliensis Branches"],"prefix":"10.3390","volume":"30","author":[{"given":"Eric","family":"Umehara","sequence":"first","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas, Universidade Federal do ABC, Santo Andr\u00e9 09280-560, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayssa A.","family":"Cajas","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisas em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos 07023-070, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel B.","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisas em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos 07023-070, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-4544","authenticated-orcid":false,"given":"Guilherme M.","family":"Antar","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Agr\u00e1rias e Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo, S\u00e3o Mateus 29932-540, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-818X","authenticated-orcid":false,"given":"Adriano D.","family":"Andricopulo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13563-120, SP, Brazil"},{"name":"Centro de Pesquisa e Inova\u00e7\u00e3o Especial em Ci\u00eancias da Descoberta de Medicamentos (CEPIMED), Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13563-120, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7031","authenticated-orcid":false,"given":"Josu\u00e9 de","family":"Moraes","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisas em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos 07023-070, SP, Brazil"},{"name":"Centro de Pesquisa e Inova\u00e7\u00e3o Especial em Ci\u00eancias da Descoberta de Medicamentos (CEPIMED), Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13563-120, SP, Brazil"},{"name":"N\u00facleo de Pesquisas em Doen\u00e7as Negligenciadas, Instituto Cient\u00edfico e Tecnol\u00f3gico, Universidade Brasil, S\u00e3o Paulo 08230-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Henrique G.","family":"Lago","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas, Universidade Federal do ABC, Santo Andr\u00e9 09280-560, SP, Brazil"},{"name":"Centro de Pesquisa e Inova\u00e7\u00e3o Especial em Ci\u00eancias da Descoberta de Medicamentos (CEPIMED), Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13563-120, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cheuka, P.M., Mayoka, G., Mutai, P., and Chibale, K. 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