{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:11:13Z","timestamp":1759921873370,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Science and Technology (DOST)-National Research Council of the Philippines (NRCP)","award":["8647","AA090088","MR\/S00520X\/1"],"award-info":[{"award-number":["8647","AA090088","MR\/S00520X\/1"]}]},{"name":"DOST-Collaborative Research and Development to Leverage Philippine Economy (CRADLE)","award":["8647","AA090088","MR\/S00520X\/1"],"award-info":[{"award-number":["8647","AA090088","MR\/S00520X\/1"]}]},{"name":"Department of Agriculture\u2014Bureau of Agricultural Research","award":["8647","AA090088","MR\/S00520X\/1"],"award-info":[{"award-number":["8647","AA090088","MR\/S00520X\/1"]}]},{"name":"Leverhulme Trust-Royal Society Africa award","award":["8647","AA090088","MR\/S00520X\/1"],"award-info":[{"award-number":["8647","AA090088","MR\/S00520X\/1"]}]},{"name":"UK Medical Research Council\u2013UK Department for International Development (MRC\/DFID) Concordat Agreement African Research Leaders Award","award":["8647","AA090088","MR\/S00520X\/1"],"award-info":[{"award-number":["8647","AA090088","MR\/S00520X\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The isolation and characterization of bioactive metabolites from Streptomyces species continue to represent a vital area of research, given their potential in natural product drug discovery. In this study, we characterize a new siderophore called legonoxamine I, together with a known compound, streptimidone, from the talented soil bacterium Streptomyces sp. MA37, using chromatographic techniques and spectroscopic analysis. Legonoxamine I is a new holo-siderophore, which is likely to be a derailed product from the biosynthetic pathway of legonoxamine A. We also demonstrate that legonoxamine A possesses potent anticancer activity (IC50 = 2.2 \u00b5M), exhibiting a remarkable ~30-fold increase in potency against MCF-7 ATCC HTB-22 breast cancer cells compared to desferrioxamine B, a structural analogue of legonoxamine A (IC50 = 61.1 \u00b5M). Comparing the structural difference between legonoxamine A and desferrioxamine B, it is deduced that the phenylacetyl moiety in legonoxamine A may have contributed significantly to its enhanced potency. Our findings contribute to the growing library of Streptomyces-derived metabolites and underscore the genus\u2019 potential as a promising source of lead compounds.<\/jats:p>","DOI":"10.3390\/molecules30020306","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T07:35:47Z","timestamp":1736840147000},"page":"306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolation and Bioactivity of Natural Products from Streptomyces sp. MA37"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0159-8337","authenticated-orcid":false,"given":"Fleurdeliz","family":"Maglangit","sequence":"first","affiliation":[{"name":"Department of Biology and Environmental Science, College of Science, University of the Philippines Cebu, Lahug, Cebu City 6000, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-5482","authenticated-orcid":false,"given":"Qing","family":"Fang","sequence":"additional","affiliation":[{"name":"Marine Biodiscovery Centre, Department of Chemistry, School of Natural and Computing Sciences, University of Aberdeen, Old Aberdeen AB24 3UE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-6572","authenticated-orcid":false,"given":"Jioji N.","family":"Tabudravu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-9497","authenticated-orcid":false,"given":"Kwaku","family":"Kyeremeh","sequence":"additional","affiliation":[{"name":"Marine and Plant Research Laboratory of Ghana, Department of Chemistry, University of Ghana, Legon-Accra P.O. Box LG56, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-6028","authenticated-orcid":false,"given":"Marcel","family":"Jaspars","sequence":"additional","affiliation":[{"name":"Marine Biodiscovery Centre, Department of Chemistry, School of Natural and Computing Sciences, University of Aberdeen, Old Aberdeen AB24 3UE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-0622","authenticated-orcid":false,"given":"Hai","family":"Deng","sequence":"additional","affiliation":[{"name":"Marine Biodiscovery Centre, Department of Chemistry, School of Natural and Computing Sciences, University of Aberdeen, Old Aberdeen AB24 3UE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1021\/acs.jnatprod.3c01012","article-title":"Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture","volume":"87","author":"Maglangit","year":"2024","journal-title":"J. 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