{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:12:52Z","timestamp":1781100772117,"version":"3.54.1"},"reference-count":49,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Asia-Japan Research Institute (AJI), Ritsumeikan Asia-Japan Research Organization, Ritsumeikan University (Ibaraki, Osaka, Japan)","award":["106.5\/E4.4\/KU\/2023"],"award-info":[{"award-number":["106.5\/E4.4\/KU\/2023"]}]},{"name":"Peningkatan Kualitas Publikasi Ilmiah (PKPI)","award":["106.5\/E4.4\/KU\/2023"],"award-info":[{"award-number":["106.5\/E4.4\/KU\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Obesity, which is characterized by excessive body fat accumulation and energy imbalance, is a major risk factor for type 2 diabetes mellitus. Boesenbergia rotunda rhizomes (known as fingerroots) exhibit a variety of pharmacological activities and are used in traditional medicine. Pinostrobin was identified as a major constituent of Boesenbergia rotunda rhizome (BR) extract and suppressed nitric oxide production in interleukin 1\u03b2-treated hepatocytes. Next, we investigated the anti-obesity effects of BR extract in ob\/ob mice, a type 2 diabetes mellitus model. The ob\/ob mice were treated with or without 1% BR extract for 14 days and then analyzed for serum insulin and triglyceride levels, liver histology, and liver mRNA expression. The administration of BR extract significantly decreased blood glucose concentrations and increased serum insulin concentrations in ob\/ob mice. In addition, this treatment reduced triglyceride levels in both the serum and liver and decreased lipid accumulation in hepatocytes. Microarray analysis revealed that hepatic mRNA affected the expression of genes involved in inflammation, lipid metabolism, lipid synthesis, and insulin signaling, leading to improvements in obesity. Because BR extract has hypoglycemic and antidiabetic effects on ob\/ob mice, it might be a promising candidate for addressing obesity and related metabolic disorders.<\/jats:p>","DOI":"10.3390\/molecules30030501","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:49:54Z","timestamp":1737611394000},"page":"501","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-Obesity Properties of Boesenbergia rotunda Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in ob\/ob Mice"],"prefix":"10.3390","volume":"30","author":[{"given":"Muhammad Hermawan","family":"Widyananda","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65113, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1971-0284","authenticated-orcid":false,"given":"Dinia Rizqi","family":"Dwijayanti","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65113, East Java, Indonesia"},{"name":"Research Center of Complementary Medicine and Functional Food, Universitas Brawijaya, Malang 65113, East Java, Indonesia"},{"name":"Asia-Japan Research Institute, Ritsumeikan Asia-Japan Research Organization, Ritsumeikan University, Ibaraki 567-8570, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Airi","family":"Fujii","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3828-4796","authenticated-orcid":false,"given":"Keita","family":"Minamisaka","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1121-5085","authenticated-orcid":false,"given":"Yuto","family":"Nishidono","sequence":"additional","affiliation":[{"name":"Research Organization of Science and Technology, Ritsumeikan University, Kusatsu 525-8577, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1117-2807","authenticated-orcid":false,"given":"Mikio","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65113, East Java, Indonesia"},{"name":"College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-498X","authenticated-orcid":false,"given":"Nashi","family":"Widodo","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65113, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.3892\/etm.2016.3667","article-title":"Obesity and Hypertension","volume":"12","author":"Jiang","year":"2016","journal-title":"Exp. 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