{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:45:59Z","timestamp":1784288759559,"version":"3.55.0"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ethambutol (EMB) is a first-line anti-tuberculosis drug that is also considered in treatment regimens for infections caused by non-tuberculous mycobacteria (NTM). EMB targets the arabinosyl transferases EmbCAB, which are important for the synthesis of cell wall constituents. To further explore and narrow down the structural variability of EMB, we synthesized three series of new EMB analogs. We tested their activity against Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium abscessus and Mycobacterium intracellulare. Only analogs that very closely resembled EMB showed comparable antimycobacterial activity.<\/jats:p>","DOI":"10.3390\/molecules30030600","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T03:26:10Z","timestamp":1738121170000},"page":"600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and Antimycobacterial Assays of Some New Ethambutol Analogs"],"prefix":"10.3390","volume":"30","author":[{"given":"Rana","family":"Abdelaziz","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-0480","authenticated-orcid":false,"given":"Mthandazo","family":"Dube","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Mann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0062-7896","authenticated-orcid":false,"given":"Adrian","family":"Richter","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Robaa","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-4291","authenticated-orcid":false,"given":"Norbert","family":"Reiling","sequence":"additional","affiliation":[{"name":"RG Microbial Interface Biology, Research Center Borstel, Leibniz Lung Center, Parkallee 1\u201340, 23845 Borstel, Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems, 23845 Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-4219","authenticated-orcid":false,"given":"Mohammad","family":"Abdel-Halim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, German University in Cairo, Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Imming","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, January 25). 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