{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:44:43Z","timestamp":1783705483278,"version":"3.55.0"},"reference-count":101,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LSU Health-New Orleans research enhancement fund","award":["R01GM136874"],"award-info":[{"award-number":["R01GM136874"]}]},{"name":"LSU Health-New Orleans research enhancement fund","award":["R21AG066119"],"award-info":[{"award-number":["R21AG066119"]}]},{"name":"USA National Institute of Health","award":["R01GM136874"],"award-info":[{"award-number":["R01GM136874"]}]},{"name":"USA National Institute of Health","award":["R21AG066119"],"award-info":[{"award-number":["R21AG066119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Royal jelly and medical grade honey are traditionally used in treating wounds and infections, although their effectiveness is often variable and insufficient. To overcome their limitations, we created novel amphiphiles by modifying the main reparative and antimicrobial components, queen bee acid (hda) and 10-hydroxyl-decanoic acid (hdaa), through peptide bonding with specific tripeptides. Our molecular design incorporated amphiphile targets as being biocompatible in wound healing, biodegradable, non-toxic, hydrogelable, prohealing, and antimicrobial. The amphiphilic molecules were designed in a hda(hdaa)-aa1-aa2-aa3 structural model with rational selection criteria for each moiety, prepared via Rink\/Fmoc-tBu-based solid-phase peptide synthesis, and structurally verified by NMR and LC\u2013MS\/MS. We tested several amphiphiles among those containing moieties of hda or hdaa and isoleucine\u2013leucine\u2013aspartate (ILD-amidated) or IL-lysine (ILK-NH2). These tests were conducted to evaluate their prohealing and antimicrobial hydrogel properties. Our observation of their hydrogelation and hydrogel-rheology showed that they can form hydrogels with stable elastic moduli and injectable shear-thinning properties, which are suitable for cell and tissue repair and regeneration. Our disc-diffusion assay demonstrated that hdaa-ILK-NH2 markedly inhibited Staphylococcus aureus. Future research is needed to comprehensively evaluate the prohealing and antimicrobial properties of these novel molecules modified from hda and hdaa with tripeptides.<\/jats:p>","DOI":"10.3390\/molecules30030615","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:42:37Z","timestamp":1738237357000},"page":"615","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Modification of Queen Bee Acid and 10-Hydroxydecanoic Acid with Specific Tripeptides: Rational Design, Organic Synthesis, and Assessment for Prohealing and Antimicrobial Hydrogel Properties"],"prefix":"10.3390","volume":"30","author":[{"given":"Song","family":"Hong","sequence":"first","affiliation":[{"name":"Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health, New Orleans, LA 70112, USA"},{"name":"Department of Ophthalmology, School of Medicine, Louisiana State University Health, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin B.","family":"Baravkar","sequence":"additional","affiliation":[{"name":"Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Razak","family":"Masoud","sequence":"additional","affiliation":[{"name":"Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9494-1398","authenticated-orcid":false,"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[{"name":"NMR Laboratory, Department of Chemistry, Tulane University, New Orleans, LA 70115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physics and AMRI, University of New Orleans, New Orleans, LA 70148, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Angioi, R., Morrin, A., and White, B. 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