{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:19:02Z","timestamp":1792095542834,"version":"4.4.0"},"reference-count":83,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R16GM145434"],"award-info":[{"award-number":["R16GM145434"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Silver nanoparticles (AgNPs) are among the most widely used nanoparticulate materials for antimicrobial applications. The innate antibacterial properties of AgNPs are closely associated with the release of silver ions (Ag+) and the generation of reactive oxygen species (ROS). Multiple reports have elaborated on the synergistic effect against bacteria by combining photosensitizers with AgNPs (PS-AgNPs). This combination allows for the light-activated generation of Ag+ and ROS from PS-AgNPs. This is an efficient and controlled approach for the effective elimination of pathogens and associated biofilms. This review summarizes the design and synthetic strategies to produce PS-AgNPs reported in the literature. First, we explore multiple bacterial cell death mechanisms associated with AgNPs and possible pathways for resistance against AgNPs and Ag+. The next sections summarize the recent findings on the design and application of PS-AgNPs for the inactivation of resistant and non-resistant bacterial strains as well as the elimination and inhibition of biofilms. Finally, the review describes major outcomes in the field and provides a perspective on the future applications of this burgeoning area of research.<\/jats:p>","DOI":"10.3390\/molecules30030626","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T09:16:26Z","timestamp":1738314986000},"page":"626","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Light-Activable Silver Nanoparticles for Combatting Antibiotic-Resistant Bacteria and Biofilms"],"prefix":"10.3390","volume":"30","author":[{"given":"Varsha","family":"Godakhindi","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223, USA"},{"name":"Nanoscale Science Program, University of North Carolina at Charlotte, Charlotte, NC 28223, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elana","family":"Kravitz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Vivero-Escoto","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223, USA"},{"name":"Nanoscale Science Program, University of North Carolina at Charlotte, Charlotte, NC 28223, USA"},{"name":"Center for Innovation, Translational Research and Applications of Nanostructured Systems, Charlotte, NC 28223, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"ref_1","first-page":"4470","article-title":"Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications","volume":"6","author":"Eckhard","year":"2021","journal-title":"Bioact. 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