{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:11:33Z","timestamp":1760029893889,"version":"build-2065373602"},"reference-count":82,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Polit\u00e9cnico Nacional","award":["20232041","20241398","20240379"],"award-info":[{"award-number":["20232041","20241398","20240379"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Peperomia campylotropa (Piperaceae) is a species with a traditional Mexican gastroprotective use that has never-before been studied using metabolomics. This study explores the ethnobotanical use of the species, aiming to define the gastroprotective effect of the aqueous extract and characterize its secondary metabolites by UHPLC\u2013MS analysis. To validate its use, we botanically identified the species re-collected in the Municipality of Buenavista de Cu\u00e9llar, Guerrero, Mexico. We conducted interviews to provide evidence of the traditional details of its consumption and knowledge. Subsequently, qualitative phytochemical tests were performed to elucidate the possible secondary metabolites, which were also characterized under UHPLC\u2013MS analysis and analyzed according to their primary type and retention times. Indomethacin (IND)- and ethanol (EtOH)-induced gastric damage models in Wistar rats were used for pharmacological evaluation, considering the ulceration index and gastroprotection percentage. Along with the participation in the mechanism of action of nitric oxide (NO), sulfhydryl (-SH) groups and prostaglandins (PG) were elucidated by Wistar rats pretreated with N(\u03c9)-nitro-L-arginine methyl ester (L-NAME), N-Ethylmaleimide (NEM), and IND, respectively. Acute intragastric toxicity was also estimated in NIH female mice. Ninety people were interviewed, revealing the traditional knowledge of P. campylotropa as food and medicine for stomach diseases, including irritation and indigestion. The presence of phenolic compounds (48%), N-containing compounds (22%), glycosides (21%), terpenoids (7%), and lactones (4%) were verified by preliminary phytochemical analysis and by UHPLC\u2013MS in which 162 secondary metabolites were characterized. Besides that, the aqueous extract at 62.5, 125, and 250 mg\/kg of body weight (b.w.) decreased the ulcerative index, showing gastroprotection percentages between 60 and 80%, similar to that of omeprazole. Furthermore, -SH group participation in its activity was established. All this evidence supports the gastroprotective activity of P. campylotropa for the first time and contributes to understanding its secondary metabolite content.<\/jats:p>","DOI":"10.3390\/molecules30040772","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T10:07:56Z","timestamp":1738922876000},"page":"772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peperomia campylotropa A.W. Hill: Ethnobotanical, Phytochemical, and Metabolomic Profile Related to Its Gastroprotective Activity"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-3149","authenticated-orcid":false,"given":"Yazm\u00edn K.","family":"M\u00e1rquez-Flores","sequence":"first","affiliation":[{"name":"Laboratorio de Toxicolog\u00eda de Productos Naturales, Departamento de Farmacia, Escuela Nacional de Ciencias Biol\u00f3gicas, Campus Zacatenco, Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu s\/n Col. Zacatenco, Ciudad de M\u00e9xico C.P. 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0582-1310","authenticated-orcid":false,"given":"Jes\u00fas","family":"Ayala-Velasco","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Renal y Hep\u00e1tica, Departamento de Farmacia, Escuela Nacional de Ciencias Biol\u00f3gicas, Campus Zacatenco, Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu s\/n, Col. Zacatenco, Ciudad de M\u00e9xico C.P. 07730, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Correa-Basurto","sequence":"additional","affiliation":[{"name":"Laboratorio de Dise\u00f1o y Desarrollo de Nuevos F\u00e1rmacos e Innovaci\u00f3n Biotecnol\u00f3gica, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Col. Casco de Santo Tomas, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5661-834X","authenticated-orcid":false,"given":"Alan","family":"Estrada-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Dise\u00f1o y Desarrollo de Nuevos F\u00e1rmacos e Innovaci\u00f3n Biotecnol\u00f3gica, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Col. Casco de Santo Tomas, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Estela","family":"Mel\u00e9ndez-Camargo","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Renal y Hep\u00e1tica, Departamento de Farmacia, Escuela Nacional de Ciencias Biol\u00f3gicas, Campus Zacatenco, Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu s\/n, Col. Zacatenco, Ciudad de M\u00e9xico C.P. 07730, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Finato, A.C., Fraga-Silva, T.F., Uliana Carvalho Prati, A., Alves de Souza, A., Mazzeu, B.F., Felippe, L.G., Pinto, R.A., De Assis Golim, M., Sueli Parreira Arruda, M., and Furlan, M. (2018). Crude Leaf Extracts of Piperaceae Species Downmodulate Inflammatory Responses by Human Monocytes. 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