{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:28Z","timestamp":1787029108904,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFF0608202"],"award-info":[{"award-number":["2022YFF0608202"]}]},{"name":"National Key Research and Development Program of China","award":["2023TD79"],"award-info":[{"award-number":["2023TD79"]}]},{"name":"National Key Research and Development Program of China","award":["2020XT08"],"award-info":[{"award-number":["2020XT08"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund, CAFS","award":["2022YFF0608202"],"award-info":[{"award-number":["2022YFF0608202"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund, CAFS","award":["2023TD79"],"award-info":[{"award-number":["2023TD79"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund, CAFS","award":["2020XT08"],"award-info":[{"award-number":["2020XT08"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFF0608202"],"award-info":[{"award-number":["2022YFF0608202"]}]},{"name":"National Key Research and Development Program of China","award":["2023TD79"],"award-info":[{"award-number":["2023TD79"]}]},{"name":"National Key Research and Development Program of China","award":["2020XT08"],"award-info":[{"award-number":["2020XT08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, an analytical method for the simultaneous determination of 14 benzodiazepine (BDZ) multiresidues in aquaculture environmental water and sediment was developed using ultra-high-performance liquid chromatography\u2013tandem mass spectrometry (UHPLC-MS\/MS). The method uses an internal standard for quantification and achieves chromatographic separation and analysis within 11 min. The results of method validation showed that the recoveries of most analytes were in the range of 70\u2013120% in water or sediment matrices, and the correlation coefficients of the 14 target chemistries were R2 &gt; 0.99, with relative standard deviations (RSD) &lt; 15%. The limits of detection (LODs) and the limits of quantification (LOQs) were in the ranges of 0.002\u20130.01 \u03bcg\/L and 0.01\u20130.03 \u03bcg\/L for water and 0.01\u20130.5 \u03bcg\/kg and 0.04\u20131 \u03bcg\/kg for the sediment matrix. The method is simple and has high rapidity, high sensitivity, and low cost. It provides technical support for the simultaneous monitoring of BDZ residues in the aquaculture environment.<\/jats:p>","DOI":"10.3390\/molecules30040775","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T11:03:51Z","timestamp":1738926231000},"page":"775","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Determination of 14 Benzodiazepine Multiresidues in Aquaculture Environment by Ultra-High-Performance Liquid Chromatography\u2013Tandem Mass Spectrometry"],"prefix":"10.3390","volume":"30","author":[{"given":"Hongyang","family":"Guo","sequence":"first","affiliation":[{"name":"School of Environmental Engineering, Wuhan Textile University, Wuhan 430073, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwu","family":"Chen","sequence":"additional","affiliation":[{"name":"Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Agriculture, Ludong University, Yantai 264025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Mei","sequence":"additional","affiliation":[{"name":"Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Gong","sequence":"additional","affiliation":[{"name":"Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdian","family":"Liu","sequence":"additional","affiliation":[{"name":"Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Li","sequence":"additional","affiliation":[{"name":"School of Environmental Engineering, Wuhan Textile University, Wuhan 430073, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Gan","sequence":"additional","affiliation":[{"name":"Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hofe, I.v., Stricker, B.H., Vernooij, M.W., Ikram, M.K., Ikram, M.A., and Wolters, F.J. 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