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Platycodon grandiflorus (PG) is a perennial herb known for its efficacy in treating respiratory infections, including asthma, cough, and bronchitis, making it a key focus in antiviral drug research. The purpose of the study is to provide a basis for functional studies on PG and generate new insights for treating viral diseases. Methods: Research articles from 1990 to 2024 related to PG and viruses were obtained from databases, such as PubMed, Web of Science, and Science Direct, and systematically analysed. Results: PG demonstrates inhibitory effects on viruses such as severe acute respiratory syndrome coronavirus and porcine reproductive and respiratory syndrome virus by blocking various stages of viral proliferation or activating the host immune system. It also reduces inflammation through NF-\u03baB, PI3K\/AKT, MAPK, and other signalling pathways, enhancing T cell and macrophage function and increasing host immunity. PG exhibits diverse pharmacological effects with promising clinical applications for antiviral and immune modulation. Given its medicinal significance, PG holds substantial potential for further exploration and development. Conclusion: PG, due to its antiviral, anti-inflammatory, and immune-boosting properties, can be used as an antiviral drug.<\/jats:p>","DOI":"10.3390\/molecules30040831","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T12:12:16Z","timestamp":1739362336000},"page":"831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Antiviral and Immune Enhancement Effect of Platycodon grandiflorus in Viral Diseases: A Potential Broad-Spectrum Antiviral Drug"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2935-8018","authenticated-orcid":false,"given":"Pei","family":"Gao","sequence":"first","affiliation":[{"name":"Postdoctoral Research Station, Henan Agriculture University, Zhengzhou 450002, China"},{"name":"Postdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"Henan International Joint Laboratory of Animal Health Breeding and Disease Prevention and Control, Xinxiang 453003, China"},{"name":"Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinshan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"Henan International Joint Laboratory of Animal Health Breeding and Disease Prevention and Control, Xinxiang 453003, China"},{"name":"Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlei","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"Henan International Joint Laboratory of Animal Health Breeding and Disease Prevention and Control, Xinxiang 453003, China"},{"name":"Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bosen","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"Henan International Joint Laboratory of Animal Health Breeding and Disease Prevention and Control, Xinxiang 453003, China"},{"name":"Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-0370","authenticated-orcid":false,"given":"Muhammad","family":"Munir","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA14YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"Henan International Joint Laboratory of Animal Health Breeding and Disease Prevention and Control, Xinxiang 453003, China"},{"name":"Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Chao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"Henan International Joint Laboratory of Animal Health Breeding and Disease Prevention and Control, Xinxiang 453003, China"},{"name":"Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfei","family":"Li","sequence":"additional","affiliation":[{"name":"Postdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China"},{"name":"Henan International Joint Laboratory of Animal Health Breeding and Disease Prevention and Control, Xinxiang 453003, China"},{"name":"Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450002, 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