{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:22:17Z","timestamp":1788805337756,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondazione Cassa di Risparmio di Trento e Rovereto","award":["2020.0265"],"award-info":[{"award-number":["2020.0265"]}]},{"name":"Fondazione Cassa di Risparmio di Trento e Rovereto","award":["CA18220"],"award-info":[{"award-number":["CA18220"]}]},{"name":"COST (European Cooperation in Science and Technology)","award":["2020.0265"],"award-info":[{"award-number":["2020.0265"]}]},{"name":"COST (European Cooperation in Science and Technology)","award":["CA18220"],"award-info":[{"award-number":["CA18220"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study explores, for the first time, the application of electrospun biobased poly(butylene 2,5-furanoate) (PBF) and poly(pentamethylene 2,5-furanoate) (PPeF) mats in biomedical and drug delivery fields, through a careful investigation of their structure\u2013property relationship. PBF mats, with a glass transition temperature (Tg) of 25\u201330 \u00b0C and an as-spun crystallinity of 18.8%, maintained their fibrous structure (fiber diameter ~1.3 \u00b5m) and mechanical properties (stiffness ~100 MPa, strength ~4.5 MPa, strain at break ~200%) under treatment in physiological conditions (37 \u00b0C, pH 7.5). In contrast, PPeF mats, being amorphous with a Tg of 14 \u00b0C, underwent significant densification, with geometrical density increasing from 0.68 g\/cm\u00b3 to 1.07 g\/cm\u00b3, which depressed the specific (i.e., normalized by density) mechanical properties. DSC analysis revealed that the treatment promoted crystallization in PBF (reaching 45.9% crystallinity), while PPeF showed limited, but interestingly not negligible, structural reorganization. Both materials promoted good cell adhesion and were biocompatible, with lactate dehydrogenase release not exceeding 20% after 48 h. The potential of PBF mats for drug delivery was evaluated using dexamethasone. The mats exhibited a controlled drug release profile, with ~10% drug release in 4 h and ~50% in 20 h. This study demonstrates the versatility of these biopolyesters in biomedical applications and highlights the impact of polymer structure on material performance.<\/jats:p>","DOI":"10.3390\/molecules30040841","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T12:12:16Z","timestamp":1739362336000},"page":"841","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Electrospun Poly(butylene 2,5-furanoate) and Poly(pentamethylene 2,5-furanoate) Mats: Structure\u2013Property Relationships and Thermo-Mechanical and Biological Characterization"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-1786","authenticated-orcid":false,"given":"Giulia","family":"Fredi","sequence":"first","affiliation":[{"name":"Department of Industrial Engineering and INSTM Research Unit, University of Trento Via Sommarive 9, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-2730","authenticated-orcid":false,"given":"Sofia","family":"Santi","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering and INSTM Research Unit, University of Trento Via Sommarive 9, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-9612","authenticated-orcid":false,"given":"Michelina","family":"Soccio","sequence":"additional","affiliation":[{"name":"Department of Civil, Chemical, Environmental, and Materials Engineering, University of Bologna, Via Terracini 28, 40131 Bologna, Italy"},{"name":"Interdepartmental Center for Industrial Research on Advanced Applications in Mechanical Engineering and Materials Technology, CIRI-MAM, Viale del Risorgimento 2, 40136 Bologna, Italy"},{"name":"Interdepartmental Center for Industrial Research on Buildings and Construction CIRI-EC, Via del Lazzaretto 15\/5, 40131 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-2934","authenticated-orcid":false,"given":"Nadia","family":"Lotti","sequence":"additional","affiliation":[{"name":"Department of Civil, Chemical, Environmental, and Materials Engineering, University of Bologna, Via Terracini 28, 40131 Bologna, Italy"},{"name":"Interdepartmental Center for Industrial Research on Advanced Applications in Mechanical Engineering and Materials Technology, CIRI-MAM, Viale del Risorgimento 2, 40136 Bologna, Italy"},{"name":"Interdepartmental Center for Industrial Agro-Food Research, CIRI-AGRO, Via Quinto Bucci 336, 47521 Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-7192","authenticated-orcid":false,"given":"Andrea","family":"Dorigato","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering and INSTM Research Unit, University of Trento Via Sommarive 9, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Adepu, S., and Ramakrishna, S. 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