{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:02:14Z","timestamp":1790996534522,"version":"4.1.0"},"reference-count":156,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Innovation with FEDER funds","award":["PID2020-113430RB-I00"],"award-info":[{"award-number":["PID2020-113430RB-I00"]}]},{"name":"Spanish Ministry of Economy and Innovation with FEDER funds","award":["2021 SGR 00304"],"award-info":[{"award-number":["2021 SGR 00304"]}]},{"name":"Regional Catalonian Government","award":["PID2020-113430RB-I00"],"award-info":[{"award-number":["PID2020-113430RB-I00"]}]},{"name":"Regional Catalonian Government","award":["2021 SGR 00304"],"award-info":[{"award-number":["2021 SGR 00304"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurodegenerative diseases such as Alzheimer\u2019s and Parkinson\u2019s diseases are among the leading causes of physical and cognitive disability across the globe. Fifty million people worldwide suffer these diseases, and that number is expected to rise as the population ages. Ictus is another pathology that also courses with neurodegeneration and is a leading cause of mortality and long-term disability in developed countries. Schizophrenia is not as common as other mental disorders, affecting approximately 24 million people worldwide. All these disorders have in common that still there is not an effective pharmacological treatment to cure them. The N-methyl-D-aspartate (NMDA) receptor (NMDAR) has attracted attention as a potential therapeutic target due to its important role in learning and memory and also due to its implication in excitotoxicity processes. Some drugs targeting NMDARs are already being used to treat symptoms of disorders affecting the central nervous system (CNS). Here, we aim to review the implications of NMDAR in these CNS pathologies, its role as a potential therapeutic target, and the future perspectives for developing new treatments focused on these receptors.<\/jats:p>","DOI":"10.3390\/molecules30040877","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T04:48:51Z","timestamp":1739508531000},"page":"877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Future Perspectives of NMDAR in CNS Disorders"],"prefix":"10.3390","volume":"30","author":[{"given":"Toni","family":"Cap\u00f3","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron171, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Biel","family":"Rebassa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron171, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iu","family":"Ra\u00efch","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron171, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Lillo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron171, 08035 Barcelona, Spain"},{"name":"Department of Biochemistry and Molecular Biomedicine, School of Biology, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9272-562X","authenticated-orcid":false,"given":"Pau","family":"Badia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-0873","authenticated-orcid":false,"given":"Gemma","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron171, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-2537","authenticated-orcid":false,"given":"Irene","family":"Reyes-Resina","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron171, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102357","DOI":"10.1016\/j.arr.2024.102357","article-title":"Neurodegenerative Disorders: Mechanisms of Degeneration and Therapeutic Approaches with Their Clinical Relevance","volume":"99","author":"Gadhave","year":"2024","journal-title":"Ageing Res. 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