{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T02:27:10Z","timestamp":1776392830879,"version":"3.51.2"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&amp;D Program of China","award":["2023YFA1507903"],"award-info":[{"award-number":["2023YFA1507903"]}]},{"name":"National Key R&amp;D Program of China","award":["2020YFA0710200"],"award-info":[{"award-number":["2020YFA0710200"]}]},{"name":"National Key R&amp;D Program of China","award":["22072046"],"award-info":[{"award-number":["22072046"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023YFA1507903"],"award-info":[{"award-number":["2023YFA1507903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020YFA0710200"],"award-info":[{"award-number":["2020YFA0710200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22072046"],"award-info":[{"award-number":["22072046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Transfer hydrogenation is a crucial technology for synthesizing fine chemicals and pharmaceuticals, offering improved safety and convenience over traditional hydrogen methods, although it typically requires external bases. While isopropanol is commonly used as a hydrogen source, methanol is superior but faces challenges due to its high dehydrogenation energy barrier, limiting its use under mild conditions. This study focuses on investigating the differences in the electrogenerated base-driven transfer hydrogenation of aromatic ketones in isopropanol and methanol solvents, using Mn(CO)\u2085Br and cyclohexanediamine derivatives as the catalyst. The research demonstrates that high enantiomeric excess (ee) values were obtained in isopropanol in the presence of chiral Mn-based catalysts, while only racemic products were observed in methanol. The results indicate a strong dependence of the catalytic pathway on the choice solvent: in isopropanol, the catalyst operates via a metal\u2013ligand cooperative transfer hydrogenation, resulting in high ee values, whereas in methanol, transfer hydrogenation occurs through metal hydride transfer with no stereoselectivity.<\/jats:p>","DOI":"10.3390\/molecules30040910","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T12:36:57Z","timestamp":1739795817000},"page":"910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Solvents on Electrogenerated Base-Driven Transfer Hydrogenation Reactions"],"prefix":"10.3390","volume":"30","author":[{"given":"Jing-Wei","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Han","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"},{"name":"College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan 756099, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9239-9888","authenticated-orcid":false,"given":"Jia-Xing","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"},{"name":"Institute of Eco-Chongming, 20 Cuiniao Road, Chenjia Town, Chongming District, Shanghai 202162, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-3475","authenticated-orcid":false,"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China"},{"name":"Institute of Eco-Chongming, 20 Cuiniao Road, Chenjia Town, Chongming District, Shanghai 202162, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1002\/tcr.201600100","article-title":"Transition-Metal-Catalyzed Asymmetric Hydrogenation and Transfer Hydrogenation: Sustainable Chemistry to Access Bioactive Molecules","volume":"16","author":"Ayad","year":"2016","journal-title":"Chem. 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