{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:25:23Z","timestamp":1791393923617,"version":"4.3.3"},"reference-count":215,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study examines the intricacies of Alzheimer\u2019s disease (AD), its origins, and the potential advantages of various herbal extracts and natural compounds for enhancing memory and cognitive performance. Future studies into AD treatments are encouraged by the review\u2019s demonstration of the effectiveness of phytoconstituents that were extracted from a number of plants. In addition to having many beneficial effects, such as improved cholinergic and cognitive function, herbal medicines are also much less harmful, more readily available, and easier to use than other treatments. They also pass without difficulty through the blood\u2013brain barrier (BBB). This study focused on natural substances and their effects on AD by using academic databases to identify peer-reviewed studies published between 2015 and 2024. According to the literature review, 66 phytoconstituents that were isolated from 21 distinct plants have shown efficacy, which could be encouraging for future research on AD therapies. Since most clinical trials produce contradictory results, the study suggests that larger-scale studies with longer treatment durations are necessary to validate or refute the therapeutic efficacy of herbal AD treatments.<\/jats:p>","DOI":"10.3390\/molecules30040922","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T12:36:57Z","timestamp":1739795817000},"page":"922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Promising Natural Remedies for Alzheimer\u2019s Disease Therapy"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-9439","authenticated-orcid":false,"given":"Amin Mahmood","family":"Thawabteh","sequence":"first","affiliation":[{"name":"Department of Chemistry, Birzeit University, West Bank, Ramallah 00972, Palestine"},{"name":"Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8634-207X","authenticated-orcid":false,"given":"Aseel Wasel","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1274-402X","authenticated-orcid":false,"given":"Sara","family":"AbuMadi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Thaher","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-1621","authenticated-orcid":false,"given":"Weam","family":"Jaghama","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donia","family":"Karaman","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, Jerusalem 20002, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-4490","authenticated-orcid":false,"given":"Rafik","family":"Karaman","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, Jerusalem 20002, Palestine"},{"name":"Department of Sciences, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"ref_1","first-page":"321","article-title":"Alzheimer\u2019s disease drug development pipeline: 2020","volume":"16","author":"Cummings","year":"2020","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Thawabteh, A.M., Ghanem, A.W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., and Karaman, R. (2024). Recent Advances in Therapeutics for the Treatment of Alzheimer\u2019s Disease. Molecules, 29.","DOI":"10.3390\/molecules29215131"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer\u2019s disease: Mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100049","DOI":"10.1016\/j.dscb.2022.100049","article-title":"The promising role of natural products in Alzheimer\u2019s disease","volume":"7","author":"Santos","year":"2022","journal-title":"Brain Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.14283\/jpad.2023.123","article-title":"Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer\u2019s Disease","volume":"10","author":"Cohen","year":"2023","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2023.11703","article-title":"Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease","volume":"330","author":"Rabinovici","year":"2023","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Abubakar, M.B., Sanusi, K.O., Ugusman, A., Mohamed, W., Kamal, H., Ibrahim, N.H., Khoo, C.S., and Kumar, J. (2022). Alzheimer\u2019s Disease: An Update and Insights Into Pathophysiology. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.742408"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chen, X., Drew, J., Berney, W., and Lei, W. (2021). Neuroprotective Natural Products for Alzheimer\u2019s Disease. Cells, 10.","DOI":"10.3390\/cells10061309"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ahmed, S., Khan, S.T., Zargaham, M.K., Khan, A.U., Khan, S., Hussain, A., Uddin, J., Khan, A., and Al-Harrasi, A. (2021). Potential therapeutic natural products against Alzheimer\u2019s disease with Reference of Acetylcholinesterase. Biomed. Pharmacother., 139.","DOI":"10.1016\/j.biopha.2021.111609"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"105401","DOI":"10.1016\/j.neuint.2022.105401","article-title":"Insights for Alzheimer\u2019s disease pharmacotherapy and current clinical trials","volume":"159","author":"Nascimento","year":"2022","journal-title":"Neurochem. Int."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, K., Yan, J., Zhou, Q., and Wang, X. (2022). Recent Progress in Research on Mechanisms of Action of Natural Products against Alzheimer\u2019s Disease: Dietary Plant Polyphenols. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213886"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102012","DOI":"10.1016\/j.arr.2023.102012","article-title":"Efficacy and safety of anti-amyloid-\u03b2 monoclonal antibodies in current Alzheimer\u2019s disease phase III clinical trials: A systematic review and interactive web app-based meta-analysis","volume":"90","author":"Jeremic","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ijbiomac.2020.07.327","article-title":"Role of tau protein in Alzheimer\u2019s disease: The prime pathological player","volume":"163","author":"Muralidar","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Breijyeh, Z., and Karaman, R. (2020). Comprehensive Review on Alzheimer\u2019s Disease: Causes and Treatment. Molecules, 25.","DOI":"10.3390\/molecules25245789"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ibneur.2022.04.009","article-title":"History in Perspective: The prime pathological players and role of phytochemicals in Alzheimer\u2019s disease","volume":"12","author":"Sajad","year":"2022","journal-title":"IBRO Neurosci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101503","DOI":"10.1016\/j.arr.2021.101503","article-title":"Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer\u2019s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies","volume":"72","author":"Song","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Picca, A., Calvani, R., Coelho-Junior, H.J., Landi, F., Bernabei, R., and Marzetti, E. (2020). Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration. Antioxidants, 9.","DOI":"10.3390\/antiox9080647"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Teleanu, D.M., Niculescu, A.-G., Lungu, I.I., Radu, C.I., Vlad\u00e2cenco, O., Roza, E., Cost\u0103chescu, B., Grumezescu, A.M., and Teleanu, R.I. (2022). An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115938"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Misrani, A., Tabassum, S., and Yang, L. (2021). Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.617588"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Agrawal, I., and Jha, S. (2020). Mitochondrial Dysfunction and Alzheimer\u2019s Disease: Role of Microglia. Front. Aging Neurosci., 12.","DOI":"10.3389\/fnagi.2020.00252"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/alz.12683","article-title":"The role of mitochondrial dysfunction in Alzheimer\u2019s disease pathogenesis","volume":"19","author":"Ashleigh","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Merighi, S., Nigro, M., Travagli, A., and Gessi, S. (2022). Microglia and Alzheimer\u2019s Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112990"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e12295","DOI":"10.1002\/trc2.12295","article-title":"Alzheimer\u2019s disease drug development pipeline: 2022","volume":"8","author":"Cummings","year":"2022","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"ref_24","first-page":"31925","article-title":"Aducanumab, a Novel Anti-Amyloid Monoclonal Antibody, for the Treatment of Alzheimer\u2019s Disease: A Comprehensive Review","volume":"10","author":"Haddad","year":"2022","journal-title":"Health Psychol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Van Oostveen, W.M., and De Lange, E.C.M. (2021). Imaging Techniques in Alzheimer\u2019s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042110"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1053\/j.semnuclmed.2020.12.005","article-title":"Advances in Brain Amyloid Imaging","volume":"51","author":"Krishnadas","year":"2021","journal-title":"Semin. Nucl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12264-016-0055-4","article-title":"Inflammatory Cytokines and Alzheimer\u2019s Disease: A Review from the Perspective of Genetic Polymorphisms","volume":"32","author":"Su","year":"2016","journal-title":"Neurosci. Bull."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/1871527316666170113120853","article-title":"Synaptic Plasticity, Dementia and Alzheimer Disease","volume":"16","author":"Skaper","year":"2017","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jconrel.2023.01.074","article-title":"Brain-neuron targeted nanoparticles for peptide synergy therapy at dual-target of Alzheimer\u2019s disease","volume":"355","author":"Guo","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Thawabteh, A.M., Ghanem, A.W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, R., Scrano, L., and Bufo, S.A. (2024). Antibacterial Activity and Antifungal Activity of Monomeric Alkaloids. Toxins, 16.","DOI":"10.3390\/toxins16110489"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s40120-022-00416-x","article-title":"Non-drug Therapies for Alzheimer\u2019s Disease: A Review","volume":"12","author":"Li","year":"2022","journal-title":"Neurol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Buccellato, F.R., D\u2019Anca, M., Tartaglia, G.M., Del Fabbro, M., Scarpini, E., and Galimberti, D. (2023). Treatment of Alzheimer\u2019s Disease: Beyond Symptomatic Therapies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241813900"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Anderson, C., Bucholc, M., McClean, P.L., and Zhang, S.-D. (2023). The Potential of a Stratified Approach to Drug Repurposing in Alzheimer\u2019s Disease. Biomolecules, 14.","DOI":"10.3390\/biom14010011"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-180766","article-title":"Treatment Combinations for Alzheimer\u2019s Disease: Current and Future Pharmacotherapy Options","volume":"67","author":"Cummings","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_36","first-page":"1751","article-title":"Anticancer prodrugs\u2014Three decades of design","volume":"4","author":"Horani","year":"2015","journal-title":"World J. Pharm. Pharm. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.37586\/2686-8636-2-2024-140-144","article-title":"Combination Drug Therapy for the Management of Alzheimer\u2019s Disease","volume":"21","author":"Dudchenko","year":"2024","journal-title":"Russ. J. Geriatr. Med."},{"key":"ref_38","first-page":"631","article-title":"Personalizing the Care and Treatment of Alzheimer\u2019s Disease: An Overview","volume":"14","author":"Strac","year":"2021","journal-title":"Pharmacogenomics Pers. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate-Armand, C., Yen, F.T., and Arab-Tehrany, E. (2022). Alzheimer\u2019s Disease: Treatment Strategies and Their Limitations. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213954"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1021\/acschemneuro.1c00206","article-title":"Evolving Role of Natural Products from Traditional Medicinal Herbs in the Treatment of Alzheimer\u2019s Disease","volume":"12","author":"Pandey","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/6873874","article-title":"Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer\u2019s Disease","volume":"2022","author":"Chakraborty","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.29252\/jmp.19.75.17","article-title":"Recommended natural products in Alzheimer\u2019s disease based on traditional Persian medicine","volume":"19","author":"Jamshidi","year":"2020","journal-title":"J. Med. Plants"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"112876","DOI":"10.1016\/j.jep.2020.112876","article-title":"Ashwagandha in brain disorders: A review of recent developments","volume":"257","author":"Zahiruddin","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Thawabteh, A.M., Thawabteh, A., Lelario, F., Bufo, S.A., and Scrano, L. (2021). Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids. Molecules, 26.","DOI":"10.3390\/molecules26134103"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szel\u0105g, M., Szklanny, D., Judasz, E., and Kaczmarek, G. (2023). Ashwagandha (Withania somnifera)\u2014Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15041057"},{"key":"ref_46","first-page":"227","article-title":"An insight to curative effects of Ashwagandha (Withania somnifera), an Ayurveda herb","volume":"8","author":"Jain","year":"2020","journal-title":"J. Med. Plants"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Bashir, A., Nabi, M., Tabassum, N., Afzal, S., and Ayoub, M. (2023). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1049334"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Das, R., Rauf, A., Akhter, S., Islam, M.N., Emran, T.B., Mitra, S., Khan, I.N., and Mubarak, M.S. (2021). Role of Withaferin A and Its Derivatives in the Management of Alzheimer\u2019s Disease: Recent Trends and Future Perspectives. Molecules, 26.","DOI":"10.3390\/molecules26123696"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s12668-020-00819-w","article-title":"Formulation Development and Characterization of Withaferin-A Loaded Polymeric Nanoparticles for Alzheimer\u2019s Disease","volume":"11","author":"Madhu","year":"2021","journal-title":"BioNanoScience"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2174\/1570159X20666220927121022","article-title":"Current Naturopathy to Combat Alzheimer\u2019s Disease","volume":"21","author":"Chakrovorty","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1080\/07391102.2023.2206909","article-title":"In silico evaluation of pharmacokinetics properties of withanolides and simulation of their biological activities against Alzheimer\u2019s disease","volume":"42","author":"Dutra","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"112769","DOI":"10.1016\/j.jep.2020.112769","article-title":"Neurodegenerative diseases and Withania somnifera (L.): An update","volume":"256","author":"Dar","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Pai, V., Chandrashekar, K.S., Pai, A., Muralidharan, A., and Setty, M.M. (2021). In-vitro and in-silico correlation studies of natural ache inhibitors: An approach towards alzheimer\u2019s disease. RASAYAN J. Chem., 83\u201391.","DOI":"10.31788\/RJC.2021.1456602"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1080\/17512433.2022.2121699","article-title":"Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry","volume":"15","author":"Andrade","year":"2022","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Bouammali, H., Zraibi, L., Ziani, I., Merzouki, M., Bourassi, L., Fraj, E., Challioui, A., Azzaoui, K., Sabbahi, R., and Hammouti, B. (2023). Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study. Plants, 13.","DOI":"10.3390\/plants13010089"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mirza, F.J., Zahid, S., and Holsinger, R.M.D. (2023). Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action. Molecules, 28.","DOI":"10.3390\/molecules28052306"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Jantas, D., Warszy\u0144ski, P., and Laso\u0144, W. (2023). Carnosic Acid Shows Higher Neuroprotective Efficiency than Edaravone or Ebselen in In Vitro Models of Neuronal Cell Damage. Molecules, 29.","DOI":"10.3390\/molecules29010119"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.2174\/0929867326666190618113613","article-title":"Natural Products as Potential Anti-Alzheimer Agents","volume":"27","author":"Panda","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Noguchi-Shinohara, M., Ono, K., Hamaguchi, T., Nagai, T., Kobayashi, S., Komatsu, J., Samuraki-Yokohama, M., Iwasa, K., Yokoyama, K., and Nakamura, H. (2020). Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer\u2019s disease progression. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-73729-2"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12272-022-01378-2","article-title":"Biomedical features and therapeutic potential of rosmarinic acid","volume":"45","author":"Noor","year":"2022","journal-title":"Arch. Pharm. Res."},{"key":"ref_61","first-page":"8288818","article-title":"Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications","volume":"2022","author":"Das","year":"2022","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Tomino, C., Ilari, S., Solfrizzi, V., Malafoglia, V., Zilio, G., Russo, P., Proietti, S., Marcolongo, F., Scapagnini, G., and Muscoli, C. (2021). Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761\u00ae). Pharmaceuticals, 14.","DOI":"10.20944\/preprints202102.0193.v1"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Xie, L., Zhu, Q., and Lu, J. (2022). Can We Use Ginkgo biloba Extract to Treat Alzheimer\u2019s Disease? Lessons from Preclinical and Clinical Studies. Cells, 11.","DOI":"10.3390\/cells11030479"},{"key":"ref_64","first-page":"173","article-title":"Therapeutic efficacy of the Ginkgo special extract EGb761\u00ae within the framework of the mitochondrial cascade hypothesis of Alzheimer\u2019s disease","volume":"20","author":"Eckert","year":"2017","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Liu, L., Wang, Y., Zhang, J., and Wang, S. (2021). Advances in the chemical constituents and chemical analysis of Ginkgo biloba leaf, extract, and phytopharmaceuticals. J. Pharm. Biomed. Anal., 193.","DOI":"10.1016\/j.jpba.2020.113704"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/cns.13536","article-title":"Strategies for the use of Ginkgo biloba extract, EGb 761\u00ae, in the treatment and management of mild cognitive impairment in Asia: Expert consensus","volume":"27","author":"Kandiah","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00204-019-02538-y","article-title":"Management of oxidative stress and other pathologies in Alzheimer\u2019s disease","volume":"93","author":"Simunkova","year":"2019","journal-title":"Arch. Toxicol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Morat\u00f3, X., Marqui\u00e9, M., Tartari, J.P., Lafuente, A., Abdelnour, C., Alegret, M., Jofresa, S., Buend\u00eda, M., Pancho, A., and Aguilera, N. (2023). A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-32515-6"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2147\/NDT.S401231","article-title":"Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review","volume":"19","author":"Hort","year":"2023","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Kuli\u0107, \u017d., Lehner, M.D., and Dietz, G.P.H. (2022). Ginkgo biloba leaf extract EGb 761\u00ae as a paragon of the product by process concept. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1007746"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4892415","DOI":"10.1155\/2020\/4892415","article-title":"Protective Effects of Quercetin on Anxiety-Like Symptoms and Neuroinflammation Induced by Lipopolysaccharide in Rats","volume":"2020","author":"Lee","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.3390\/cimb44110356","article-title":"Quercetin Alleviates Lipopolysaccharide-Induced Cell Damage and Inflammation via Regulation of the TLR4\/NF-\u03baB Pathway in Bovine Intestinal Epithelial Cells","volume":"44","author":"Gong","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.intimp.2018.01.002","article-title":"Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4\/MyD88 pathway","volume":"56","author":"Cheng","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Yang, Y.-L., Cheng, X., Li, W.-H., Liu, M., Wang, Y.-H., and Du, G.-H. (2019). Kaempferol Attenuates LPS-Induced Striatum Injury in Mice Involving Anti-Neuroinflammation, Maintaining BBB Integrity, and Down-Regulating the HMGB1\/TLR4 Pathway. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030491"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Alaqeel, N.K., AlSheikh, M.H., and Al-Hariri, M.T. (2022). Quercetin Nanoemulsion Ameliorates Neuronal Dysfunction in Experimental Alzheimer\u2019s Disease Model. Antioxidants, 11.","DOI":"10.3390\/antiox11101986"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11849","DOI":"10.1021\/acsomega.0c01818","article-title":"Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health","volume":"5","author":"Salehi","year":"2020","journal-title":"ACS Omega"},{"key":"ref_77","first-page":"25","article-title":"Ocimum Tenuiflorum Linne: A Narrative Review","volume":"3","author":"Kasmara","year":"2024","journal-title":"Int. J. Nurs. Inf."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1007\/s13197-020-04417-2","article-title":"Phytochemical and antioxidant profiling of Ocimum sanctum","volume":"57","author":"Chaudhary","year":"2020","journal-title":"J. Food Sci. Technol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"108709","DOI":"10.1016\/j.exppara.2024.108709","article-title":"Chemical composition and mosquitocidal properties of essential oil from Indian indigenous plants Ocimum tenuiflorum L. and Ocimum americanum L. against three vector mosquitoes","volume":"258","author":"Ragavendran","year":"2024","journal-title":"Exp. Parasitol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Maru, H., Sharma, K., Mishra, S.K., and John, G.J. (2023). A Comprehensive Review of Ethnomedical Uses, Phytochemical Studies, and Properties of Holy basil (Ocimum sanctum Linn.). Pharmacological Benefits of Natural Agents, IGI Global.","DOI":"10.4018\/978-1-6684-6737-4.ch004"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5530\/ctbp.2021.1.10","article-title":"Holy basil: A Potential Herbal Source for Therapeutic Applications","volume":"15","author":"Dakshayani","year":"2020","journal-title":"Curr. Trends Biotechnol. Pharm."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"102069","DOI":"10.1016\/j.jchemneu.2021.102069","article-title":"Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer\u2019s disease","volume":"120","author":"Nandini","year":"2022","journal-title":"J. Chem. Neuroanat."},{"key":"ref_83","first-page":"41","article-title":"Acetylcholinesterase activity of Ocimum Sanctum leaf extract","volume":"8","author":"Kandhan","year":"2018","journal-title":"J. Adv. Pharm. Educ. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2497354","DOI":"10.1155\/2021\/2497354","article-title":"Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review","volume":"2021","author":"Nisar","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Ulanowska, M., and Olas, B. (2021). Biological Properties and Prospects for the Application of Eugenol\u2014A Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073671"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s13311-023-01376-2","article-title":"The Promise of Niacin in Neurology","volume":"20","author":"Wuerch","year":"2023","journal-title":"Neurotherapeutics"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.2174\/1568026621666210701141433","article-title":"Eugenol as a Potential Drug Candidate: A Review","volume":"21","author":"Taleuzzaman","year":"2021","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3165159","DOI":"10.1155\/2021\/3165159","article-title":"Pleiotropic Effects of Eugenol: The Good, the Bad, and the Unknown","volume":"2021","author":"Aburel","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_89","first-page":"290","article-title":"A succinct review on the therapeutic potential and delivery systems of Eugenol","volume":"4","author":"Eleleemy","year":"2020","journal-title":"Arch. Pharm. Sci. Ain Shams Univ."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Mawaddani, N., Wibowo, N.R., Nadhira, Q.H., and Pramifta, R.A. (2020). In silico study of Centella asiatica active compound as BACE1 inhibitor in Alzheimer\u2019s disease. J. Smart Bioprosp. Technol., 1.","DOI":"10.21776\/ub.jsmartech.2020.001.02.3"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"115220","DOI":"10.1016\/j.jep.2022.115220","article-title":"Exploration of essential oil from Psychotria poeppigiana as an anti-hyperalgesic and anti-acetylcholinesterase agent: Chemical composition, biological activity and molecular docking","volume":"296","author":"Formagio","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jtcme.2020.08.002","article-title":"Identification of phytochemicals from North African plants for treating Alzheimer\u2019s diseases and of their molecular targets by in silico network pharmacology approach","volume":"11","author":"Raafat","year":"2021","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"108352","DOI":"10.1016\/j.neuropharm.2020.108352","article-title":"Efficacy of acetylcholinesterase inhibitors in Alzheimer\u2019s disease","volume":"190","author":"Marucci","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"117957352110291","DOI":"10.1177\/11795735211029113","article-title":"The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer\u2019s Disease","volume":"13","author":"Vecchio","year":"2021","journal-title":"J. Cent. Nerv. Syst. Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"883","DOI":"10.18596\/jotcsa.913136","article-title":"Turmeric (Curcuma longa L.): Chemical Components and Their Effective Clinical Applications","volume":"8","author":"Vo","year":"2021","journal-title":"J. Turk. Chem. Soc. Sect. A Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1002\/ptr.7224","article-title":"A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents","volume":"35","author":"Razavi","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Dai, R., Sun, Y., Su, R., and Gao, H. (2022). Anti-Alzheimer\u2019s disease potential of traditional chinese medicinal herbs as inhibitors of BACE1 and AChE enzymes. Biomed. Pharmacother., 154.","DOI":"10.1016\/j.biopha.2022.113576"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Mansouri, K., Rasoulpoor, S., Daneshkhah, A., Abolfathi, S., Salari, N., Mohammadi, M., Rasoulpoor, S., and Shabani, S. (2020). Clinical effects of curcumin in enhancing cancer therapy: A systematic review. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07256-8"},{"key":"ref_99","first-page":"472","article-title":"Curcumin and Its Derivatives: A Review of Their Biological Activities","volume":"11","author":"Oglah","year":"2020","journal-title":"Syst. Rev. Pharm."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Thawabteh, A.M., Jibreen, A., Karaman, D., Thawabteh, A., and Karaman, R. (2023). Skin Pigmentation Types, Causes and Treatment\u2014A Review. Molecules, 28.","DOI":"10.20944\/preprints202305.0751.v1"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Talebi, M., \u0130lg\u00fcn, S., Ebrahimi, V., Talebi, M., Farkhondeh, T., Ebrahimi, H., and Samarghandian, S. (2021). Zingiber officinale ameliorates Alzheimer\u2019s disease and Cognitive Impairments: Lessons from preclinical studies. Biomed. Pharmacother., 133.","DOI":"10.1016\/j.biopha.2020.111088"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Czernicka, L., Ludwiczuk, A., R\u00f3j, E., Marzec, Z., Jarzab, A., and Kukula-Koch, W. (2020). Acetylcholinesterase Inhibitors among Zingiber officinale Terpenes\u2014Extraction Conditions and Thin Layer Chromatography-Based Bioautography Studies. Molecules, 25.","DOI":"10.3390\/molecules25071643"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Ivanovi\u0107, M., Makoter, K., and Razbor\u0161ek, M.I. (2021). Comparative Study of Chemical Composition and Antioxidant Activity of Essential Oils and Crude Extracts of Four Characteristic Zingiberaceae Herbs. Plants, 10.","DOI":"10.3390\/plants10030501"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5530\/ajbls.2024.13.30","article-title":"Comparative Phytochemical Analysis of Curcuma aromatic, C. aeruginosa and C. angustifolia","volume":"13","author":"Kundamveetil","year":"2024","journal-title":"Asian J. Biol. Life Sci."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Arya, A., Chahal, R., Rao, R., Rahman, M.H., Kaushik, D., Akhtar, M.F., Saleem, A., Khalifa, S.M.A., El-Seedi, H.R., and Kamel, M. (2021). Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer\u2019s Disease Therapy. Biomolecules, 11.","DOI":"10.3390\/biom11030350"},{"key":"ref_106","first-page":"15","article-title":"Comparative Study on the Chemical Constituents of Curcuma Drugs","volume":"2","author":"Nishidono","year":"2020","journal-title":"J. Asia-Jpn. Res. Inst. Ritsumeikan Univ."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e01655","DOI":"10.1002\/brb3.1655","article-title":"Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer\u2019s disease by up-regulating SIRT1","volume":"10","author":"Xu","year":"2020","journal-title":"Brain Behav."},{"key":"ref_108","first-page":"665","article-title":"The Golden Spice for Life: Turmeric with the Pharmacological Benefits of Curcuminoids Components, including Curcumin, Bisdemethoxycurcumin, and Demethoxycurcumin","volume":"20","author":"Sun","year":"2023","journal-title":"Curr. Org. Synth."},{"key":"ref_109","first-page":"7","article-title":"Demothoxycurcumin as a curcumin analogue with anticancer, antimicrobial, anti-inflammatory, and neuroprotective activities: Micro and nanosystems","volume":"2","author":"Rizvi","year":"2023","journal-title":"Nano Micro Biosyst."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"428","DOI":"10.37360\/blacpma.20.19.5.30","article-title":"Therapeutic potential of Zingiberaceae in Alzheimer\u2019s disease","volume":"19","author":"Trettel","year":"2020","journal-title":"Bolet\u00edn Latinoam. Y Caribe Plantas Med. Y Arom\u00e1ticas"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Elhawary, E.A., Moussa, A.Y., and Singab, A.N.B. (2024). Genus Curcuma: Chemical and ethnopharmacological role in aging process. BMC Complement. Med. Ther., 24.","DOI":"10.1186\/s12906-023-04317-w"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Zhuang, S., Liu, B., Guo, S., Xue, Y., Wu, L., Liu, S., Zhang, C., and Ni, X. (2021). Germacrone alleviates neurological deficits following traumatic brain injury by modulating neuroinflammation and oxidative stress. BMC Complement. Med. Ther., 21.","DOI":"10.1186\/s12906-020-03175-0"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/01635581.2020.1749676","article-title":"Therapeutic Effects of Curcumol in Several Diseases; An Overview","volume":"73","author":"Hashem","year":"2020","journal-title":"Nutr. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/1567205018666210716122034","article-title":"Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer\u2019s Disease","volume":"18","author":"Seibel","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bioorg.2018.09.027","article-title":"Bioactivity-based analysis and chemical characterization of anti-inflammatory compounds from Curcuma zedoaria rhizomes using LPS-stimulated RAW264.7 cells","volume":"82","author":"Lee","year":"2019","journal-title":"Bioorganic Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"44","DOI":"10.37275\/ehi.v1i2.10","article-title":"Curcuma zedoaria (Christm.) Roscoe (Benefits And Bioactivity)","volume":"1","author":"Silalahi","year":"2020","journal-title":"Eureka Herba Indones."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Thawabteh, A., Juma, S., Bader, M., Karaman, D., Scrano, L., Bufo, S., and Karaman, R. (2019). The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens. Toxins, 11.","DOI":"10.3390\/toxins11110656"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"41","DOI":"10.47070\/ijapr.v9i5.1917","article-title":"Brahmi (bacopa monnieri)\u2014a potential ayurvedic cognitive enhancer and neuroprotective herb","volume":"9","author":"Choudhary","year":"2021","journal-title":"Int. J. Ayurveda Pharma Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.1002\/ptr.7203","article-title":"Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders","volume":"35","author":"Banerjee","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.sajb.2023.03.007","article-title":"A triterpenoid saponin bacoside-A3 from the aerial parts of Bacopa monnieri (L.) Wettst. with acetylcholinesterase enzyme combating Alzheimer\u2019s disease","volume":"156","author":"Logesh","year":"2023","journal-title":"South Afr. J. Bot."},{"key":"ref_121","first-page":"168","article-title":"Effect of Bacopa monnieri Extract on Memory and Cognitive Skills in Adult Humans: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"8","author":"Eraiah","year":"2024","journal-title":"J. Psychiatry Cogn. Behav."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"767","DOI":"10.4103\/aian.AIAN_610_19","article-title":"Efficacy of bacopa monnieri (Brahmi) and Donepezil in Alzheimer\u2019s Disease and mild cognitive impairment: A randomized double-blind parallel Phase 2b study","volume":"23","author":"Prabhakar","year":"2020","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Brimson, J.M., Brimson, S., Prasanth, M.I., Thitilertdecha, P., Malar, D.S., and Tencomnao, T. (2021). The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: Analysis of the available clinical data. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-80045-2"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Fatima, U., Roy, S., Ahmad, S., Ali, S., Elkady, W.M., Khan, I., Alsaffar, R.M., Adnan, M., Islam, A., and Hassan, M.I. (2022). Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.972379"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"117739281986641","DOI":"10.1177\/1177392819866412","article-title":"Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies","volume":"13","author":"Manap","year":"2019","journal-title":"Drug Target Insights"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000475900","article-title":"Neu- rocognitive effect of nootropic drug brahmi (Bacopa monnieri) in Alzheimer\u2019s disease","volume":"24","author":"Chaudhari","year":"2017","journal-title":"Ann. Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2017.10.002","article-title":"The effects of betulinic acid on neurobehavioral activity, electrophysiology and histological changes in an animal model of the Alzheimer\u2019s disease","volume":"337","author":"Navabi","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Lou, H., Li, H., Zhang, S., Lu, H., and Chen, Q. (2021). A Review on Preparation of Betulinic Acid and Its Biological Activities. Molecules, 26.","DOI":"10.3390\/molecules26185583"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Oliveira-Costa, J.F., Meira, C.S., Neves, M.V.G.D., Reis, B.P.Z.C.D., and Soares, M.B.P. (2022). Anti-Inflammatory Activities of Betulinic Acid: A Review. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.883857"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Bakrim, S., Benkhaira, N., Bourais, I., Benali, T., Lee, L.-H., Omari, N.E., Sheikh, R.A., Goh, K.W., Ming, L.C., and Bouyahya, A. (2022). Health Benefits and Pharmacological Properties of Stigmasterol. Antioxidants, 11.","DOI":"10.3390\/antiox11101912"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Anwar, S., Mohammad, T., Azhar, M.K., Fatima, H., Alam, A., Hasan, G.M., Islam, A., Kaur, P., and Hassan, M.I. (2023). Investigating MARK4 inhibitory potential of Bacopaside II: Targeting Alzheimer\u2019s disease. Int. J. Biol. Macromol., 245.","DOI":"10.1016\/j.ijbiomac.2023.125364"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Dubey, T., and Chinnathambi, S. (2019). Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer\u2019s disease. Arch. Biochem. Biophys., 676.","DOI":"10.1016\/j.abb.2019.108153"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Linh, N.N., Huong, N.T.M., Dai, D.N., Giang, N.T.A., Huong, L.T., Thuy, T.T.T., and Son, N. (2024). Camellia annamensis (Theaceae): Phytochemical analysis, cytotoxic, antioxidative, and antimicrobial activities. Nat. Prod. Res., 1\u20137.","DOI":"10.1080\/14786419.2024.2302900"},{"key":"ref_134","first-page":"7","article-title":"Phytochemical Composition and Toxicity Evaluation of Camellia sinensis (L.) O.Kuntze (Theaceae) (Green Tea) Leaves Collected from Mambila Beverages Ltd Nigeria","volume":"6","author":"Ukwubile","year":"2020","journal-title":"Int. J. Med. Plants Nat. Prod."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"100001","DOI":"10.1016\/j.phyplu.2020.100001","article-title":"Phytochemical characterization and biological activities of green tea (Camellia sinensis) produced in the Azores, Portugal","volume":"1","author":"Barreira","year":"2021","journal-title":"Phytomed. Plus"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Tewani, K., and Monika, M. (2022). Phytochemical analysis, anti-oxidant activity, anti-microbial activity of leaves of camellia sinensis (theaceae family) (white tea). Int. J. Health Sci., 5457\u20135469.","DOI":"10.53730\/ijhs.v6nS3.7147"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"114286","DOI":"10.1016\/j.lwt.2022.114286","article-title":"Comprehensive analysis of carotenoids constituents in purple-coloured leaves and carotenoid-derived aroma differences after processing into green, black, and white tea","volume":"173","author":"Shi","year":"2023","journal-title":"LWT"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Arafah, A., Khatoon, S., Rasool, I., Khan, A., Rather, M.A., Abujabal, K.A., Faqih, Y.A.H., Rashid, H., Rashid, S.M., and Ahmad, S.B. (2023). The Future of Precision Medicine in the Cure of Alzheimer\u2019s Disease. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020335"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Khan, M.I., Khan, M.Z., Shin, J.H., Shin, T.S., Lee, Y.B., Kim, M.Y., and Kim, J.D. (2022). Neuroprotective effects of green tea seed isolated saponin due to the amelioration of tauopathy and alleviation of neuroinflammation: A therapeutic approach to Alzheimer\u2019s disease. Molecules, 27.","DOI":"10.3390\/molecules27072079"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Tchamgoue, J., Ngandjui, Y.A.T., Talla, R.M., Ambamba, B.D.A., Tchouankeu, J.C., and Kouam, S.F. (2023). Extraction of Phytoconstituents for Lifestyle Diseases. Role of Herbal Medicines: Management of Lifestyle Diseases, Springer Nature Singapore.","DOI":"10.1007\/978-981-99-7703-1_3"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Geiser, R.J., Chastain, S.E., and Moss, M.A. (2017). Regulation of bace1 mRNA expression in Alzheimer\u2019s disease by green tea catechins and black tea theaflavins. Biophys. J., 112.","DOI":"10.1016\/j.bpj.2016.11.1965"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.fbio.2019.03.009","article-title":"The impact of oolong and black tea polyphenols on human health","volume":"29","author":"Zhang","year":"2019","journal-title":"Food Biosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jmf.2023.K.0180","article-title":"The Antiobesity Effects and Potential Mechanisms of Theaflavins","volume":"27","author":"Fang","year":"2024","journal-title":"J. Med. Food"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"104895","DOI":"10.1016\/j.neuint.2020.104895","article-title":"GABA-enriched teas as neuro-nutraceuticals","volume":"141","author":"Hinton","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Uddin, M.S., Kabir, M.T., Niaz, K., Jeandet, P., Christophe, C., Mathew, B., Rauf, A., Rengasamy, K.R.R., Sobarzo-S\u00e1nchez, E., and Ashraf, G.M. (2020). Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer\u2019s Disease. Molecules, 25.","DOI":"10.3390\/molecules25061267"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Chen, S., Kang, J., Zhu, H., Wang, K., Han, Z., Wang, L., Liu, J., Wu, Y., He, P., and Tu, Y. (2023). L-Theanine and Immunity: A Review. Molecules, 28.","DOI":"10.3390\/molecules28093846"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"114077","DOI":"10.1016\/j.physbeh.2023.114077","article-title":"Theaflavin-3,3\u2032-digallate ameliorates learning and memory impairments in mice with premature brain aging induced by D-galactose","volume":"261","author":"Cao","year":"2023","journal-title":"Physiol. Behav."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"62","DOI":"10.20425\/ijts1419","article-title":"Black Tea: A Possible Multitherapeutic Combinatorics Aiding Neuroprotection in Alzheimer\u2019s Disease","volume":"14","author":"Bhandari","year":"2018","journal-title":"Int. J. Tea Sci."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Ide, K., Matsuoka, N., Yamada, H., Furushima, D., and Kawakami, K. (2018). Effects of Tea Catechins on Alzheimer\u2019s Disease: Recent Updates and Perspectives. Molecules, 23.","DOI":"10.3390\/molecules23092357"},{"key":"ref_150","first-page":"26","article-title":"Tinospora cordifolia: A New Perspective on Alzheimer\u2019s Disease and Green Nanotechnology","volume":"13","author":"Kothari","year":"2023","journal-title":"Nat. Prod. J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"23634","DOI":"10.1021\/acsomega.4c01219","article-title":"Tinospora cordifolia Extract Enhances Dextromethorphan Bioavailability: Implications for Alzheimer\u2019s Disease","volume":"9","author":"Majhi","year":"2024","journal-title":"ACS Omega"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"113850","DOI":"10.1016\/j.jep.2021.113850","article-title":"Cissampelos pareira L.: A review of its traditional uses, phytochemistry, and pharmacology","volume":"274","author":"Kumari","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/epj.epj_57_20","article-title":"Hepatoprotective activity of hydroalcoholic extract of Cissampelos pareira linn. leaves against CCl4-induced acute and chronic hepatotoxicity","volume":"20","author":"Asif","year":"2021","journal-title":"Egypt. Pharm. J."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1111\/ejn.16250","article-title":"Molecular interplay between phytoconstituents of Ficus Racemosa and neurodegenerative diseases","volume":"59","author":"Rani","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"ref_155","first-page":"187","article-title":"Effects of natural remedies on memory loss and Alzheimer\u2019s disease","volume":"6","author":"Sharma","year":"2024","journal-title":"Afr. J. Bio Sci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"14","DOI":"10.20546\/ijcrbp.2021.801.002","article-title":"Biosciences and Plant Biology","volume":"8","author":"Malabadi","year":"2021","journal-title":"Int. J. Curr. Res. Biosci. Plant Biol."},{"key":"ref_157","first-page":"1","article-title":"Moringa oleifera as the potential herb medicine for neurodegenerative diseases: A narrative review","volume":"5","author":"Dewi","year":"2024","journal-title":"Muhammadiyah J. Geriatr."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"14358","DOI":"10.1021\/acs.jafc.1c04581","article-title":"Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases","volume":"69","author":"Ghimire","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_159","unstructured":"Djiogue, S., Youmbi, K.I., Seke, E.P.F., Kandeda, K.A., Zemo, G.F., Motoum, T.F., Tadah, R.N.D., and Dieudonne, N. (2022). Neuroprotective Effects of the Aqueous Extract of Leaves of Moringa oleifera (Moringaceae) in Scopolamine-Treated Rats. BioMed, 14."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"104638","DOI":"10.1016\/j.jff.2021.104638","article-title":"Pharmacological properties of glabridin (a flavonoid extracted from licorice): A comprehensive review","volume":"85","author":"Li","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Eltahir, A.O.E., Omoruyi, S.I., Augustine, T.N., Luckay, R.C., and Hussein, A.A. (2024). Neuroprotective Effects of Glycyrrhiza glabra Total Extract and Isolated Compounds. Pharmaceuticals, 17.","DOI":"10.3390\/ph17070852"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1021\/acschemneuro.0c00273","article-title":"Clitoria ternatea Mediated Synthesis of Graphene Quantum Dots for the Treatment of Alzheimer\u2019s Disease","volume":"11","author":"Tak","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"104785","DOI":"10.1016\/j.neuint.2020.104785","article-title":"The nootropic and anticholinesterase activities of Clitoria ternatea Linn. root extract: Potential treatment for cognitive decline","volume":"139","author":"Damodaran","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Mehla, J., Gupta, P., Pahuja, M., Diwan, D., and Diksha, D. (2020). Indian Medicinal Herbs and Formulations for Alzheimer\u2019s Disease, from Traditional Knowledge to Scientific Assessment. Brain Sci., 10.","DOI":"10.3390\/brainsci10120964"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"128","DOI":"10.37896\/YMER21.04\/13","article-title":"A review on sesbania grandiflora its effect on the treatment of dementia and neuro disease and other diseases","volume":"21","author":"Kumar","year":"2022","journal-title":"YMER Digit."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"20","DOI":"10.52711\/2231-5713.2022.00004","article-title":"Phytochemical and Pharmacological Review of Sesbania grandiflora","volume":"12","author":"Dange","year":"2022","journal-title":"Asian J. Pharm. Technol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"9211","DOI":"10.1039\/D1FO01720A","article-title":"Neuroprotective effects of macamide from maca (Lepidium meyenii Walp.) on corticosterone-induced hippocampal impairments through its anti-inflammatory, neurotrophic, and synaptic protection properties","volume":"12","author":"Yu","year":"2021","journal-title":"Food Funct."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Paternina-Ricardo, S., Salgado, B.A., and Espi\u00f1eira, M.C.G. (2022). Effects of aqueous and ethanolic extracts of Lepidium meyenii Walp (red and black maca) on Caenorhabditis elegans. Acta Sci. Biol. Sci., 44.","DOI":"10.4025\/actascibiolsci.v44i1.58300"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/07391102.2021.2005681","article-title":"Jatamansinol from Nardostachys jatamansi: A multi-targeted neuroprotective agent for Alzheimer\u2019s disease","volume":"41","author":"Anupama","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"82","DOI":"10.58414\/SCIENTIFICTEMPER.2022.13.1.12","article-title":"A Review on Endangered Medicinal Plant Nardostachys jatamansi: An Important Himalayan Herb","volume":"13","author":"Pant","year":"2022","journal-title":"Sci. Temper"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"105764","DOI":"10.1016\/j.fitote.2023.105764","article-title":"Nardostachys jatamansi: Phytochemistry, ethnomedicinal uses, and pharmacological activities: A comprehensive review","volume":"172","author":"Pathak","year":"2024","journal-title":"Fitoterapia"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neuro.2022.02.011","article-title":"Jatamansinol from Nardostachys jatamansi (D.Don) DC. Protects A\u03b242-Induced Neurotoxicity in Alzheimer\u2019s Disease Drosophila Model","volume":"90","author":"Anupama","year":"2022","journal-title":"NeuroToxicology"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.1007\/s12035-022-02964-7","article-title":"Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer\u2019s Disease Model","volume":"59","author":"Anupama","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1007\/s12035-016-9839-9","article-title":"Resveratrol and Alzheimer\u2019s Disease: Mechanistic Insights","volume":"54","author":"Ahmed","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/nyas.13431","article-title":"Resveratrol for Alzheimer\u2019s disease","volume":"1403","author":"Sawda","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.arr.2017.02.004","article-title":"Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation","volume":"36","author":"Rahimifard","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1089\/dna.2018.4308","article-title":"Resveratrol Suppresses A\u03b2-Induced Microglial Activation Through the TXNIP\/TRX\/NLRP3 Signaling Pathway","volume":"38","author":"Feng","year":"2019","journal-title":"DNA Cell Biol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13063-016-1426-x","article-title":"The efficacy of resveratrol in controlling hypertension: Study protocol for a randomized, crossover, double-blinded, placebo-controlled trial","volume":"17","author":"Movahed","year":"2016","journal-title":"Trials"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Broderick, T.L., Rasool, S., Li, R., Zhang, Y., Anderson, M., Al-Nakkash, L., Plochocki, J.H., Geetha, T., and Babu, J.R. (2020). Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197337"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1471-4159.2011.07594.x","article-title":"Resveratrol mitigates lipopolysaccharide- and A\u03b2-mediated microglial inflammation by inhibiting the TLR4\/NF-\u03baB\/STAT signaling cascade","volume":"120","author":"Capiralla","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"155344","DOI":"10.1016\/j.phymed.2024.155344","article-title":"Anti-inflammatory effects of quinolinyl analog of resveratrol targeting TLR4 in MCAO\/R ischemic stroke rat model","volume":"128","author":"Xu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Yang, W., Zhou, K., Zhou, Y., An, Y., Hu, T., Lu, J., Huang, S., and Pei, G. (2018). Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP\/PS1 Transgenic Mice. Front. Aging Neurosci., 10.","DOI":"10.3389\/fnagi.2018.00169"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/ptr.6305","article-title":"Naringenin promotes microglial M2 polarization and A\u03b2 degradation enzyme expression","volume":"33","author":"Yang","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/cns.13086","article-title":"Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4\/NF-\u03baB signaling pathway","volume":"25","author":"Jin","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"106092","DOI":"10.1016\/j.intimp.2019.106092","article-title":"Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2\/NF-\u03baB expressions and regulation of metabolic abnormality","volume":"79","author":"Yan","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1007\/s12035-022-02858-8","article-title":"Neuroprotective Effect of Baicalein Against Oxaliplatin-Induced Peripheral Neuropathy: Impact on Oxidative Stress, Neuro-inflammation and WNT\/\u03b2-Catenin Signaling","volume":"59","author":"Jugait","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ijnp\/pyaa060","article-title":"Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3\/Caspase-1\/GSDMD Pathway in MPTP-Induced Mice Model of Parkinson\u2019s Disease","volume":"23","author":"Rui","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Wu, J.-J., Yang, Y., Wan, Y., Xia, J., Xu, J.-F., Zhang, L., Liu, D., Chen, L., Tang, F., and Ao, H. (2022). New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer\u2019s disease. Biomed. Pharmacother., 152.","DOI":"10.1016\/j.biopha.2022.113207"},{"key":"ref_190","first-page":"717","article-title":"Ginsenoside Rg1 protects against H2O2-induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro","volume":"43","author":"Xu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3892\/etm.2022.11482","article-title":"Ginsenoside Rg1 ameliorates apoptosis, senescence and oxidative stress in ox-LDL-induced vascular endothelial cells via the AMPK\/SIRT3\/p53 signaling pathway","volume":"24","author":"Lyu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_192","first-page":"899","article-title":"Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor-\u03baB pathway and inhibition of inflammasome activation in alcoholic hepatitis","volume":"41","author":"Li","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1021\/acschemneuro.2c00005","article-title":"Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer\u2019s Disease Mouse Model","volume":"13","author":"Abdallah","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Omar, S., Scott, C., Hamlin, A., and Obied, H. (2018). Olive Biophenols Reduces Alzheimer\u2019s Pathology in SH-SY5Y Cells and APPswe Mice. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010125"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Rishmawi, S., Haddad, F., Dokmak, G., and Karaman, R. (2022). A Comprehensive Review on the Anti-Cancer Effects of Oleuropein. Life, 12.","DOI":"10.3390\/life12081140"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1002\/ptr.7424","article-title":"An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd","volume":"36","author":"Nagpal","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Hajam, T.A., and Saleem, H. (2022). Phytochemistry, biological activities, industrial and traditional uses of fig (Ficus carica): A review. Chem.-Biol. Interact., 368.","DOI":"10.1016\/j.cbi.2022.110237"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s12272-020-01285-4","article-title":"Phytochemical and pharmacological properties of Myristica fragrans Houtt.: An updated review","volume":"43","author":"Ha","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"24951","DOI":"10.1039\/D0RA03576A","article-title":"Pharmacological and natural products diversity of the brown algae genusSargassum","volume":"10","author":"Rushdi","year":"2020","journal-title":"RSC Adv."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Cristea, R.M., Sava, C., C\u0103p\u0103\u021b\u00e2n\u0103, C., and Kanellou, A. (2024). Phytochemical Analysis and Specific Activities of Bark and Flower Extracts from Four Magnolia Plant Species. Horticulturae, 10.","DOI":"10.3390\/horticulturae10020141"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"117957352090739","DOI":"10.1177\/1179573520907397","article-title":"Current and Future Treatments in Alzheimer Disease: An Update","volume":"12","author":"Yiannopoulou","year":"2020","journal-title":"J. Cent. Nerv. Syst. Dis."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s13346-019-00694-3","article-title":"Nanotechnology to improve the Alzheimer\u2019s disease therapy with natural compounds","volume":"10","author":"Ramalho","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e09575","DOI":"10.1016\/j.heliyon.2022.e09575","article-title":"Liposomes: An emerging carrier for targeting Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"8","author":"Pandian","year":"2022","journal-title":"Heliyon"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Hassan, N.A., Alshamari, A.K., Hassan, A.A., Elharrif, M.G., Alhajri, A.M., Sattam, M., and Khattab, R.R. (2022). Advances on Therapeutic Strategies for Alzheimer\u2019s Disease: From Medicinal Plant to Nanotechnology. Molecules, 27.","DOI":"10.3390\/molecules27154839"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"7","DOI":"10.51847\/qDMSgl63u7","article-title":"Pharmacogenomic Approaches in Alzheimers Disease: A Comprehensive Review","volume":"13","author":"Bhat","year":"2023","journal-title":"Int. J. Pharm. Phytopharm. Res."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Cacabelos, R., Naidoo, V., Mart\u00ednez-Iglesias, O., Corzo, L., Cacabelos, N., Pego, R., and Carril, J.C. (2022). Pharmacogenomics of Alzheimer\u2019s Disease: Novel Strategies for Drug Utilization and Development. Pharmacogenomics in Drug Discovery and Development, Springer US.","DOI":"10.1007\/978-1-0716-2573-6_13"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"9935942","DOI":"10.1155\/2023\/9935942","article-title":"The Effective Components, Core Targets, and Key Pathways of Ginseng against Alzheimer\u2019s Disease","volume":"2023","author":"Wang","year":"2023","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u0392 pathway in Alzheimer\u2019s disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_209","unstructured":"(2025, January 29). National Plan to Address Alzheimer\u2019s Disease, Available online: https:\/\/aspe.hhs.gov\/sites\/default\/files\/documents\/3c45034aec6cf63414b8ed7351ce7d95\/napa-national-plan-2023-update.pdf."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1001\/jamaneurol.2023.3810","article-title":"Brexpiprazole for the treatment of agitation in Alzheimer dementia","volume":"80","author":"Lee","year":"2023","journal-title":"JAMA Neurol."},{"key":"ref_211","first-page":"2","article-title":"Recruitment and retention of participant and study partner dyads in two multinational Alzheimer\u2019s disease registration trials","volume":"13","author":"Bernstein","year":"2021","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_212","first-page":"5380346","article-title":"Clinical trials in Alzheimer\u2019s disease: A hurdle in the path of remedy","volume":"2020","author":"Oxford","year":"2020","journal-title":"Int. J. Alzheimer\u2019s Dis."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.trci.2018.04.003","article-title":"Digital technologies as biomarkers, clinical outcomes assessment, and recruitment tools in Alzheimer\u2019s disease clinical trials","volume":"4","author":"Gold","year":"2018","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/alz.12737","article-title":"Recommendations to address key recruitment challenges of Alzheimer\u2019s disease clinical trials","volume":"19","author":"Langbaum","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1377\/hlthaff.2013.1314","article-title":"Obstacles and opportunities in Alzheimer\u2019s clinical trial recruitment","volume":"33","author":"Watson","year":"2014","journal-title":"Health Aff."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/4\/922\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:36:01Z","timestamp":1760027761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/4\/922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":215,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["molecules30040922"],"URL":"https:\/\/doi.org\/10.3390\/molecules30040922","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]}}}