{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:50:07Z","timestamp":1782766207663,"version":"3.54.5"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Research and Graduate Studies at King Khalid University","award":["RGP2\/580\/45"],"award-info":[{"award-number":["RGP2\/580\/45"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Increasing cases of sunburn is one of the serious problems across the globe. In this connection, there is an urgent requirement for some effective sun screening agents. In the search for the same, nanoemulsions of some new synthesized and characterized chalcone derivatives were prepared and evaluated in vitro and in vivo. In order to meet the said objective, in the first step, vanillin was reacted with 4-aminoacetophenone in the presence of 15% sodium hydroxide and ethanol to synthesize the target compounds (C-1 to C-5). Progress of reaction was monitored using thin-layer chromatography (TLC). The crystals of purified compounds were characterized using spectroscopic techniques such as Infrared (IR) spectroscopy, 1H-NMR spectroscopy, 13C-NMR, and mass spectrometry. We prepared the nanoemulsions of the final compounds (C-1 to C-5) and subsequently evaluated them for in vitro sun protection factor activity. The concentration of the nanoemulsions, consistently ranging from 0.88 to 0.91 mg\/mL across all formulations, demonstrated a high degree of consistency. The range of particle size varied from approximately 172 to 183 nm, with low polydispersity index values (approximately 0.11 to 0.15). The negative zeta potentials recorded for all the formulations (ranging from \u221235.87 mV to \u221239.30 mV) showed that the nanoemulsions are electrostatically stable enough to keep them from sticking together. The pH values of the nanoemulsions ranged narrowly from approximately 5.00 to 5.16, which indicated the compatibility of emulsion with biological systems and the potential to reduce irritation or instability during administration. The viscosity of the nanoemulsions varied between 2.00 and 2.12 cP. In silico studies were performed using MMP-I and MMP-2 as target receptors. For in vitro SPF evaluation, the Mansur equation was employed. COLIPA guidelines were compiled for in vivo SPF evaluation. The nanoemulsions derived from compounds C-3 and C-4, designated as C-3NE and C-4NE, were more effective as anti-aging agents. Findings suggested the possible scope of further synthesis of newer synthetic derivatives of chalcones for furfur development nanoemulsions for better SPF activity.<\/jats:p>","DOI":"10.3390\/molecules30051057","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T12:01:17Z","timestamp":1740484877000},"page":"1057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis, Characterization, and Docking Studies of Some New Chalcone Derivatives to Alleviate Skin Damage Due to UV Light"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-988X","authenticated-orcid":false,"given":"Arun Kumar","family":"Mishra","sequence":"first","affiliation":[{"name":"SOS School of Pharmacy, Faculty of Pharmacy, IFTM University, Moradabad 244102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-8544","authenticated-orcid":false,"given":"Kamal Y.","family":"Thajudeen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 611441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra","family":"Shekhar","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad 244102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhaveer","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad 244102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad 244102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad 244102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh Kumar","family":"Paliwal","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Banasthali Vidyapith, Banasthali 304022, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emdad","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahana","family":"Salam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu 333053, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/rpd\/ncp234","article-title":"Quantitative Evaluation of Personal Exposure to UV Radiation of Workers and General Public","volume":"137","author":"Sisto","year":"2009","journal-title":"Radiat. 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