{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:40:07Z","timestamp":1784227207205,"version":"3.55.0"},"reference-count":48,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Provincial Fund Project","award":["202401CF070069"],"award-info":[{"award-number":["202401CF070069"]}]},{"name":"Yunnan Provincial Fund Project","award":["202101AT070262"],"award-info":[{"award-number":["202101AT070262"]}]},{"name":"Yunnan Provincial Fund Project","award":["202301BD070001-162"],"award-info":[{"award-number":["202301BD070001-162"]}]},{"name":"Yunnan Provincial Agricultural Basic Research Joint Special Project","award":["202401CF070069"],"award-info":[{"award-number":["202401CF070069"]}]},{"name":"Yunnan Provincial Agricultural Basic Research Joint Special Project","award":["202101AT070262"],"award-info":[{"award-number":["202101AT070262"]}]},{"name":"Yunnan Provincial Agricultural Basic Research Joint Special Project","award":["202301BD070001-162"],"award-info":[{"award-number":["202301BD070001-162"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To discover novel fungicides with good inhibitory effects on plant fungal diseases, twenty-five 3-indolyl-3-hydroxy oxindole derivatives (3a\u20133y) were synthesized. These newly derivatives were characterized by NMR and HRMS. Their antifungal activities against five plant pathogenic fungi were assessed in vitro. Most of the compounds exhibited moderate to excellent antifungal activities against the five pathogenic fungi. Notably, compounds 3t, 3u, 3v, and 3w displayed remarkable and broad-spectrum antifungal activities comparable to or superior to those of the fungicides carvacrol (CA) and phenazine-1-carboxylic acid (PCA). Among them, compound 3u displayed the most excellent antifungal activity against Rhizoctonia solani K\u00fchn (R. solani), with an EC50 of 3.44 mg\/L, which was superior to CA (7.38 mg\/L) and PCA (11.62 mg\/L). Preliminary structure\u2013activity relationship (SAR) results indicated that the introduction of I, Cl, or Br substituents at position 5 of the 3-hydroxy-2-oxindole and indole rings is crucial for compounds to exhibit good antifungal activity. The in vivo antifungal activity assay showed that compound 3u has good curative effects against R. solani. The current results suggest that these compounds are capable of serving as promising lead compounds.<\/jats:p>","DOI":"10.3390\/molecules30051079","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T11:22:12Z","timestamp":1740568932000},"page":"1079","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis, Characterization, and Evaluation of the Antifungal Properties of 3-Indolyl-3-Hydroxy Oxindole Derivatives Against Plant Pathogenic Fungi"],"prefix":"10.3390","volume":"30","author":[{"given":"Zhiqiang","family":"Bai","sequence":"first","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"},{"name":"College of Science, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunrong","family":"Dang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrui","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjing","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawu","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.FUNK-0023-2016","article-title":"Plant Pathogenic Fungi","volume":"5","author":"Doehlemann","year":"2017","journal-title":"Microbiol. 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