{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:04:32Z","timestamp":1790139872153,"version":"4.0.1"},"reference-count":122,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wuhu Science and Technology Innovation Strategy Research Special Project","award":["2024swwzx07"],"award-info":[{"award-number":["2024swwzx07"]}]},{"name":"Wuhu Science and Technology Innovation Strategy Research Special Project","award":["[2024]117"],"award-info":[{"award-number":["[2024]117"]}]},{"name":"the \u201cDouble-Teacher and Dual-Ability\u201d Teacher Team Construction Project of Anhui Provincial Department of Education","award":["2024swwzx07"],"award-info":[{"award-number":["2024swwzx07"]}]},{"name":"the \u201cDouble-Teacher and Dual-Ability\u201d Teacher Team Construction Project of Anhui Provincial Department of Education","award":["[2024]117"],"award-info":[{"award-number":["[2024]117"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Vitamin E succinate is a more mature vitamin E derivative, and its chemical stability and many effects have been improved compared with vitamin E, which can not only make up for the shortcomings of vitamin E application but also broaden the application field of vitamin E. At present, in developed countries such as Europe, America, and Japan, vitamin E succinate is widely used in health foods, and due to its good water solubility and stability, the vitamin E added to most nutritional supplements (tablets and hard capsules) is vitamin E succinate. At the same time, vitamin E succinate used in the food and pharmaceutical industries is mainly catalyzed by enzymatic catalysis. In this paper, Candida rugosa lipase (CRL) was studied. Chemical modification and immobilization were used to improve the enzymatic properties of CRL, and immobilized lipase with high stability and high activity was obtained. It was applied to the enzymatic synthesis of vitamin E succinate, and the reaction conditions were optimized to improve the yield and reduce the production cost. The review covered the research progress of the methods for enhancing the catalytic performance of immobilized enzymes and discussed its application in the synthesis of vitamin E succinate, providing new ideas and technical support for the catalytic performance enhancement of immobilized enzymes and its application in the synthesis of vitamin E succinate and promoting the production and application of vitamin E succinate.<\/jats:p>","DOI":"10.3390\/molecules30061241","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:02:59Z","timestamp":1741608179000},"page":"1241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Research Progress on the Enhancement of Immobilized Enzyme Catalytic Performance and Its Application in the Synthesis of Vitamin E Succinate"],"prefix":"10.3390","volume":"30","author":[{"given":"Liang","family":"Qu","sequence":"first","affiliation":[{"name":"School of Food and Bioengineering, Wuhu Institute of Technology, Wuhu 241003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongya","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanzhuo","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Ni","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-8776","authenticated-orcid":false,"given":"Bin","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.molcatb.2006.06.012","article-title":"Lipase-catalyzed transesterification of rapeseed oils for biodiesel production with a novel organic solvent as the reaction medium","volume":"43","author":"Li","year":"2006","journal-title":"J. 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