{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:19:44Z","timestamp":1771978784645,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["01-2022"],"award-info":[{"award-number":["01-2022"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["451-03-136\/2025-03\/200168"],"award-info":[{"award-number":["451-03-136\/2025-03\/200168"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["451-03-136\/2025-03\/200026"],"award-info":[{"award-number":["451-03-136\/2025-03\/200026"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":["01-2022"],"award-info":[{"award-number":["01-2022"]}]},{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":["451-03-136\/2025-03\/200168"],"award-info":[{"award-number":["451-03-136\/2025-03\/200168"]}]},{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":["451-03-136\/2025-03\/200026"],"award-info":[{"award-number":["451-03-136\/2025-03\/200026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Five previously undescribed tigliane diterpenes (1\u20134 and 7), along with three known tiglianes (5, 6, and 8) were isolated from the root extract of Euphorbia nicaeensis using chromatographic techniques. The structures of the isolated compounds were determined using spectroscopic techniques. The isolated compounds were tested for anti-HIV activity against HIV-1 NL4.3 and HIV-2 ROD strains. Two derivatives (2 and 8) exhibited significant anti-HIV activity, with IC50 values ranging from 1.10 to 7.47 \u00b5M. This study highlights the potential of E. nicaeensis root as a source of novel bioactive tigliane derivatives, warranting further investigation for possible use in HIV treatment.<\/jats:p>","DOI":"10.3390\/molecules30071452","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T08:42:35Z","timestamp":1742892155000},"page":"1452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti-HIV Activity of Tigliane Derivatives from Euphorbia nicaeensis Roots"],"prefix":"10.3390","volume":"30","author":[{"given":"Gordana","family":"Krsti\u0107","sequence":"first","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11010 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-3504","authenticated-orcid":false,"given":"Milka","family":"Jadranin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Belgrade\u2014Institute of Chemistry, Technology and Metallurgy, Njego\u0161eva 12, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-5850","authenticated-orcid":false,"given":"Dominique","family":"Schols","sequence":"additional","affiliation":[{"name":"Translational Virology, Laboratory of Molecular, Structural and Rega Institute, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9255-9199","authenticated-orcid":false,"given":"Sandra","family":"Claes","sequence":"additional","affiliation":[{"name":"Translational Virology, Laboratory of Molecular, Structural and Rega Institute, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7060-9055","authenticated-orcid":false,"given":"Vele","family":"Te\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11010 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Mandi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11010 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0925-327X","authenticated-orcid":false,"given":"Slobodan","family":"Milosavljevi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11010 Belgrade, Serbia"},{"name":"Serbian Academy of Science and Arts, Kneza Mihaila 35, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0936-6709","authenticated-orcid":false,"given":"Karlo","family":"Wittine","sequence":"additional","affiliation":[{"name":"Selvita Ltd., Prilaz baruna Filipovi\u0107a 29, 10000 Zagreb, Croatia"},{"name":"Faculty of Biotechnology and Drug Development, University of Rijeka, Radmile Matej\u010di\u0107 2, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1021\/cr078350s","article-title":"Chemical and pharmacological research of the plants in genus","volume":"108","author":"Shi","year":"2008","journal-title":"Euphorbia. 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