{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:44:41Z","timestamp":1789785881903,"version":"4.0.1"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["2022R1C1C1009806"],"award-info":[{"award-number":["2022R1C1C1009806"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["2022R1A2C2007696"],"award-info":[{"award-number":["2022R1A2C2007696"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ultrasound (US)-based sonodynamic therapy (SDT) presents a promising and secure approach to treating cancer with the advantage of enhanced tissue penetration, making it a favorable option compared with traditional photodynamic therapy. However, the search for innovative sonosensitizers that exhibit both high sonosensitizing efficacy and good biocompatibility poses a formidable challenge. In this research, we prepared a novel BODIPY-Zn complex (BSS-Zn) incorporating a hydrophilic short polyethylene glycol unit and explored its feasibility as a sonosensitizer. BSS-Zn exhibited enhanced reactive oxygen species (ROS) generation behavior upon US irradiation, outperforming a control sensitizer, BSS (an analog lacking the Zn complex), and a commercial sonosensitizer, ZnPc (currently undergoing clinical testing), with regard to sonosensitizing properties. The enhanced effect of BSS-Zn was attributed to increased levels of ROS, such as hydroxyl radicals, singlet oxygen, and superoxide, mediated by US exposure in aqueous media. The SDT effect of BSS-Zn on MDA-MB-231 cells was verified by confirming the intracellular types of generated ROS and evaluating the cytotoxicity to MDA-MB-231 cancer cells. This pioneering study highlights the potential of BSS-Zn as an innovative sonosensitizer for SDT. Our findings provide valuable guidance for the design of efficient sonosensitizers.<\/jats:p>","DOI":"10.3390\/molecules30071587","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T07:47:44Z","timestamp":1743580064000},"page":"1587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Novel BODIPY-Zn Complex as Innovative Sonosensitizer for Enhanced Sonodynamic Therapy"],"prefix":"10.3390","volume":"30","author":[{"given":"Jungmin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biomedical & Chemical Sciences, Hyupsung University, Hwasung-si 18330, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soeun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Chemical Sciences, Hyupsung University, Hwasung-si 18330, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gihoon","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Chemical Sciences, Hyupsung University, Hwasung-si 18330, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunbin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Chemical Sciences, Hyupsung University, Hwasung-si 18330, Republic of Korea"},{"name":"Department of Gerontology (AgeTech-Service Convergence Major), Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Chemical Sciences, Hyupsung University, Hwasung-si 18330, Republic of Korea"},{"name":"Department of Gerontology (AgeTech-Service Convergence Major), Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-3086","authenticated-orcid":false,"given":"Jiyou","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Chemical Sciences, Hyupsung University, Hwasung-si 18330, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2018-8226","authenticated-orcid":false,"given":"Hyo Sung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Chemical Sciences, Hyupsung University, Hwasung-si 18330, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11227","DOI":"10.1039\/D1CS00403D","article-title":"Advanced Biotechnology-Assisted Precise Sonodynamic Therapy","volume":"50","author":"Zhang","year":"2021","journal-title":"Chem. 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