{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:56:04Z","timestamp":1768467364058,"version":"3.49.0"},"reference-count":58,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the present study, the extraction of volatile terpenes from A. annua with supercritical CO2 (sc-CO2) was optimized by a full factorial design procedure and compared with conventional distillation. The influence of pressure (100\u2013220 bar) and temperature (40\u201360 \u00b0C) on sc-CO2 extraction was investigated to obtain extracts rich in the desired components while maintaining a high yield. Extraction yields (m\/m) varied from 0.62% (130 bar\/40 \u00b0C) to 1.92% (100 bar\/60 \u00b0C). Monoterpenes were the most abundant constituents of the sc-CO2 extracts, among which artemisia ketone (16.93\u201348.49%), camphor (3.29\u201318.44%) and 1,8-cineole (4.77\u201311.89%) dominated. Arteannuin B (3.98\u201310.03%) and \u03b2-selinene (1.05\u20137.42%) were the major sesquiterpenes. Differences were found between the terpene profiles of the sc-CO2 extracts and the essential oils obtained by conventional hydrodistillation and steam distillation, as well as between the distilled essential oils. Our results demonstrate the optimal conditions for the rapid and effective supercritical extraction of certain monoterpenes and sesquiterpenes from A. annua, which have promising antimicrobial, antioxidant, antiviral, anti-inflammatory and antitumor properties.<\/jats:p>","DOI":"10.3390\/molecules30071638","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:30:59Z","timestamp":1744003859000},"page":"1638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Green Extraction of Volatile Terpenes from Artemisia annua L."],"prefix":"10.3390","volume":"30","author":[{"given":"Marta","family":"Mandi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, University of Mostar, Matice Hrvatske BB, 88000 Mostar, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivona","family":"Ivan\u010di\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Mostar, Matice Hrvatske BB, 88000 Mostar, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-8092","authenticated-orcid":false,"given":"Matija","family":"Cvetni\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Maruli\u0107a 19, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-9407","authenticated-orcid":false,"given":"Claudio","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, D\u2019Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66013 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giustino","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, D\u2019Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66013 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7510-4205","authenticated-orcid":false,"given":"Sanda","family":"Vladimir-Kne\u017eevi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kova\u010di\u0107a 1, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"ref_1","first-page":"66","article-title":"Molecular phylogeny and evolution of floral characters of Artemisia and allies (Anthemideae, Asteraceae): Evidence from NrDNA ETS and ITS sequences","volume":"57","author":"Sanz","year":"2008","journal-title":"Taxon"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Anibogwu, R., Jesus, K.D., Pradhan, S., Pashikanti, S., Mateen, S., and Sharma, K. 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