{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:42Z","timestamp":1787029122626,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>As the number of new breast cancer cases grows around the world, there is an unmet need for fast, accurate, and low-cost methods of early cancer detection. It was previously shown that X-ray scattering on lipid molecules can provide the necessary structural biomarker. However, these measurements were performed on small ex vivo samples, and to ensure the progress to in vivo diagnostics, the approach should be extended to larger tissues. We use the phantom fat samples to establish such a procedure. In the obtained X-ray scattering patterns, we observe the characteristic features for the inter-fatty-acid molecular distance. The large size of the samples led to the peak broadening; however, the features remain visible up to 10 cm in thickness. The experimental data are in excellent agreement with the Monte Carlo simulations based on the form factors obtained from the small samples. Our results usher the way for the in vivo monitoring of the structural biomarkers of breast cancer.<\/jats:p>","DOI":"10.3390\/molecules30081655","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T09:47:55Z","timestamp":1744105675000},"page":"1655","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Toward In Vivo Cancer Detection: X-Ray Scattering on Thick Phantom Samples"],"prefix":"10.3390","volume":"30","author":[{"given":"Viacheslav","family":"Kubytskyi","sequence":"first","affiliation":[{"name":"Matur UK Ltd., 5 New Street Square, London EC4A 3TW, UK"},{"name":"Laboratoire de Physique des 2 Infinis Ir\u00e8ne Joliot-Curie, UMR9012, CNRS, Universit\u00e9 Paris-Saclay, B\u00e2t. 209, 91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masroor","family":"Khonkhodzhaev","sequence":"additional","affiliation":[{"name":"Matur UK Ltd., 5 New Street Square, London EC4A 3TW, UK"},{"name":"Physics Department, Queens College, City University of New York, 65-30 Kissena Blvd, Flushing, NY 11367, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aika","family":"Tanaka","sequence":"additional","affiliation":[{"name":"EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Nguyen","sequence":"additional","affiliation":[{"name":"EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lazarev","sequence":"additional","affiliation":[{"name":"EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Aram","sequence":"additional","affiliation":[{"name":"EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0423-8940","authenticated-orcid":false,"given":"Keith","family":"Rogers","sequence":"additional","affiliation":[{"name":"EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA"},{"name":"Shrivenham Campus, Cranfield University, Swindon SN6 8LA, Wiltshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-7251","authenticated-orcid":false,"given":"Lev","family":"Mourokh","sequence":"additional","affiliation":[{"name":"Physics Department, Queens College, City University of New York, 65-30 Kissena Blvd, Flushing, NY 11367, USA"},{"name":"EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Lazarev","sequence":"additional","affiliation":[{"name":"Matur UK Ltd., 5 New Street Square, London EC4A 3TW, UK"},{"name":"EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"ref_1","unstructured":"(2024). 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